Dry suspensoid of Repirinast and its prepn. method
A technology of dry suspension and repimilast, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of uneven distribution of active ingredients of drugs and inability of drugs to reach Therapeutic effect, poor dispersion of granules and other problems, to achieve the effect of good compliance, good absorption and high dispersion
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Embodiment 1
[0020] Take the crushed: 50g repimilast, 20g sodium carboxymethylcellulose as suspending agent, 50g lactose as filler, 100g sucrose as flavoring agent, after mixing, pass through 200 mesh sieve, then 5g talcum powder as Lubricant, mix evenly and dispense.
Embodiment 2
[0022] The proportioning and production method of this example and Example 1 are basically the same, the difference is only: 30g of sodium citrate is also used as a flocculant in the raw materials mixed for the first time.
Embodiment 3
[0024] A. Take the pulverized: 50g repimilast, 2g hydroxypropyl methylcellulose sodium as suspending agent, 500g microcrystalline cellulose as filler, 10g mannitol as flavoring agent, 30g sodium citrate as flocculation Agents were dried and mixed and passed through a 80-mesh sieve. B. Add 20g of 50% ethanol (i.e. pure ethanol 10g) as a binder system soft material, cross 18 mesh sieves for granulation, and make dry granules after drying. The drying time is sufficient when the water content in the material is less than or equal to 1%, usually about 2 hours. C. Add 0.1g of micropowder silica gel as lubricant and 0.05g of butter essence to the dry granules, mix evenly, and pack them separately.
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