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Medicine for treating endometriosis and its prepn

A technology for endometriosis and ectopic disease, which can be used in pharmaceutical formulations, drug combinations, drug delivery, etc., and can solve the problems of difficult swallowing by patients and difficulty in swallowing the total amount of granules.

Active Publication Date: 2007-01-03
程雪翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use the 160mg / tablet large-scale tablet produced by Bristol-Myers Squibb Company. Although the number of tablets taken each time is small, each tablet is as big as a peanut and it is difficult for patients to swallow
Especially for seriously ill patients with weak constitution, it is more difficult or even impossible to swallow tablets with large particles and large total amount several times a day

Method used

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  • Medicine for treating endometriosis and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] The preparation of embodiment 1 dispersible tablet

[0103] Ingredients: Megestrol Acetate 100g

[0104] Sodium starch glycolate 23.8g

[0105] Crospovidone 17g

[0106] Pregelatinized starch 17g,

[0107] Microcrystalline Cellulose 178.8g

[0108] Silica 3.4g,

[0109] 5% polyvinylpyrrolidone ethanol solution appropriate amount

[0110] Take by weighing medroxyprogesterone acetate, carboxymethyl starch sodium, crospovidone, pregelatinized starch, and microcrystalline cellulose of the prescribed amount, and pass through a 100-mesh sieve to mix them evenly; add an appropriate amount of 5 Mix the ethanol solution of % polyvinylpyrrolidone to make a soft material; press the soft material through a 20-mesh sieve to make granules; after the wet granules are made, immediately put them in an oven to dry at 60°C, and take them out after drying for 20 minutes; use 30 The purpose sieve is sized, add silicon dioxide, and mix well. Tablet;...

Embodiment 2

[0111] Embodiment 2, the preparation of capsule

[0112] Ingredients: Megestrol Acetate 100g

[0113] Sodium starch glycolate 23.8g

[0114] Crospovidone 17g

[0115] Pregelatinized starch 17g,

[0116] Microcrystalline Cellulose 178.8g

[0117] Magnesium Stearate Appropriate amount

[0118] 5% polyvinylpyrrolidone ethanol solution appropriate amount

[0119] Take by weighing medroxyprogesterone acetate, carboxymethyl starch sodium, crospovidone, pregelatinized starch, and microcrystalline cellulose of the prescribed amount, and pass through a 100-mesh sieve to mix them evenly; add an appropriate amount of 5 Mix the ethanol solution of % polyvinylpyrrolidone to make a soft material; press the soft material through a 20-mesh sieve to make granules; after the wet granules are made, immediately put them in an oven to dry at 60°C, and take them out after drying for 20 minutes; use 30 Purpose Sieve the grains, mix them evenly, divide them i...

Embodiment 3

[0120]Example 3 Preparation of Granules

[0121] Ingredients: Megestrol Acetate 100g

[0122] Appropriate amount of sucrose

[0123] Proper amount of hypromellose

[0124] Other Appropriate amount

[0125] Weigh the prescribed amount of raw materials medroxyprogesterone acetate and other auxiliary materials through a 100-mesh sieve, prepare hypromellose with pure water to a suitable concentration as an adhesive, mix the remaining raw materials and auxiliary materials evenly, and use the prepared Adhesive granulation, drying at 60-65°C, granulation, sieving, packaging; finished product inspection, packaging.

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Abstract

The present invention is one kind of medicine for treating endometriosis and its preparation process. The medicine is dispersant tablet comprising medicinal material megestrol acetate and corresponding supplementary material, and may be also prepared into other pharmaceutically acceptable forms, such as pill, common tablet, granule, oral liquid, etc. The medicine has obvious curative effect on endometriosis, stable quality, and other advantages.

Description

technical field [0001] The invention relates to the technical field of manufacturing technology of chemical medicine dispersible tablets and other clinically acceptable pharmaceutical dosage forms, in particular to a pharmaceutical preparation for treating endometriosis and a preparation method thereof. Background technique [0002] Endometriosis is a disease in which the endometrium or endometrium-like tissue is not in the normal part of the uterine cavity, but appears in other parts outside the uterus. Since the etiology of endometriosis is unknown, although there are treatments such as surgical resection of adhesions, hormone administration and analgesic administration, they are all symptomatic treatments, and there is no fundamental treatment. [0003] Megestrol Acetate (Megestrol Acetate) is a kind of progestogen medicine invented by Searle Company of the United States in 1959, and is used for treating gynecological diseases such as women's irregular menstruation. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K9/06A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K47/38A61P15/00
Inventor 程雪翔
Owner 程雪翔
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