Bacteriostatic externally applied preparation for treating gynecological inflammation and method for preparing same

A technology for external preparations and gynecological inflammation, applied in the field of external preparations and its preparation, can solve the problems of vaginal, urethral and anal cross-infection, single efficacy, toxic and side effects, etc., and achieve ideal therapeutic effect, rapid effect, and long-term effect

Inactive Publication Date: 2006-12-20
杨晋懿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Vaginitis, cervicitis, and pelvic inflammatory disease are common diseases of women. At the same time, due to the special reasons of the physiological structure of women's genitals and vagina, women's genitals and vagina are easily infected with Staphylococcus aureus, Candida albicans and mold, Pseudomonas aeruginosa bacteria and Pseudomonas aeruginosa, Escherichia coli, saccharomyces, trichomonas, etc., so vaginitis, cervicitis, pelvic inflammatory disease, etc. are common problems in women's genitals and vagina, and the related treatments of these problems in the prior art have adopted other drugs such as antibiotics And other dosage forms, but the use of antibiotics will have certain toxic and side effects on the liver, kidney and related organs, and will also affect the normal beneficial bacteria flora of the vagina, thereby causing damage to the self-cleaning and defense capabilities of the vagina, and easily causing vaginal, urethra, anal cross infection
[0003] At present, although many medicines for vaginal bacteriostasis and treatment of vaginitis, cervicitis and other gynecological and genital diseases have also appeared, their dosage forms are very traditional, and their effects and effects are not direct enough. It is mainly liquid, and the curative effect is not very satisfactory, and the vaginal medicine gel used as gynecological inflammation is still a new dosage form at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 of the present invention: Weigh 60g of raw materials medicinal materials Sophorae flavescens, 40g of rhubarb, 30g of Cnidium, 20g of Phellodendron cortex, 20g of Smilax smilax, 30g of white tinea bark, 20g of Radix chinensis, 30g of wild chrysanthemum, 30g of Senecio, 20g of Sichuan pepper, Crane louse 20g, Evodia rutaecarpa 20g, Vitex bark 20g, Gentiana 30g, catechu 25g, Angelica dahurica 30g, Kochia scoparia 30g, after quick panning, put in the seepage tank and decoct for 2 times, the first time add water higher than The medicinal material is 5cm, decocted for 3 hours, add water for the second time just to submerge the medicinal material, decoct for 2 hours, combine the decoction, filter, and measure the clear paste with a relative density of 1.02 when the filtrate is concentrated to 60°C, and leave the above clear paste for 24 hour, take out the supernatant, add water to 1500Kg to obtain a diluted medicinal solution, take 30% of the diluted medicinal solu...

Embodiment 2

[0023]Embodiment 2 of the present invention: Weigh and wash 60g of raw medicinal materials Sophora flavescens, 40g of rhubarb, 30g of Cnidium, 30g of Cortex Phellodendri, 60g of Smilax cocos, 30g of white tinea bark, 30g of Baibu, 30g of wild chrysanthemum, 30g of Senecio, Sichuan 30g pepper, 20g crane louse, 30g Evodia rutaecarpa, 30g echinacea, 50g gentian, 45g catechin, 50g angelica dahurica, 50g Kochia scoparia, after quick panning, put in a multifunctional extraction tank, add water to infiltrate, open the clamp Heat the cover until boiling, decoct 3 times, add water 6cm higher than the herbs for the first time, decoct for 2 hours, add water for the second time just submerge the herbs, decoct for 1.5 hours, add water for the third time just submerge the herbs, decoct for 1 hour, Combine 3 decoctions, filter, and measure the clear paste with a relative density of 1.02 when the filtrate is concentrated to 60°C, add benzoic acid 10g, clarifier, purified water to 1500kg to obt...

Embodiment 3

[0024] Embodiment 3 of the present invention: Weigh 10 g of raw medicinal materials Sophora flavescens, 10 g of rhubarb, 10 g of Cnidium, 10 g of Phellodendron cortex, 10 g of Smilax smilax, 10 g of white tinea bark, 10 g of Radix chinensis, 10 g of wild chrysanthemum, 10 g of Senecio, 5 g of Sichuan pepper, Crane louse 5g, Evodia rutaecarpa 5g, Vitex bark 5g, Gentiana 10g, catechu 10g, Angelica dahurica 10g, Kochia scoparia 10g. The medicinal material is 3cm, decocted for 1 hour, add water for the second time just to submerge the medicinal material, decoct for 1.5 hours, combine the decoction, filter, and measure the clear paste with a relative density of 1.02 when the filtrate is concentrated to 60°C; take another appropriate amount of glycerin gelatin in a water bath Heat it in medium temperature to dissolve, after completely dissolving evenly, add the above-mentioned clear ointment, stir evenly, injection molding, cooling, demolding, packaging, and suppository is obtained.

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PUM

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Abstract

The invention relates to a Chinese pharmaceutical composition for treating gynaecologic inflammation and process for preparation, wherein the composition is prepared from flavescent sophora root, rhubarb horsetails, cnidium fruit, corktree bark, poria cocos, Chinese dittany bark, roor of sessile stemona, wild chrysanthemum flower, Senecio scandens, zanthoxylum piperitum, carpesium fruit, evodia rutaecarpa, cortex pseudolaricis, gentian root, black catechu, dahurian angelica root, broom cypress fruit, dried alum, borax, metronidazole and auxiliary materials.

Description

Technical field: [0001] The invention relates to an external preparation and a preparation method thereof, in particular to an external preparation for inhibiting bacteria and treating gynecological inflammation and a preparation method thereof, belonging to the technical field of antibacterial preparations. Background technique: [0002] Vaginitis, cervicitis, and pelvic inflammatory disease are common diseases of women. At the same time, due to the special reasons of the physiological structure of women's genitals and vagina, women's genitals and vagina are easily infected with Staphylococcus aureus, Candida albicans and mold, Pseudomonas aeruginosa bacteria and Pseudomonas aeruginosa, Escherichia coli, saccharomyces, trichomonas, etc., so vaginitis, cervicitis, pelvic inflammatory disease, etc. are common problems in women's genitals and vagina, and the related treatments of these problems in the prior art have adopted other drugs such as antibiotics And other dosage form...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/00A61K9/02A61P15/00A61P15/02A61P31/04A61P31/10A61P33/02A61K33/22A61K33/06A61K31/4164
Inventor 杨晋懿
Owner 杨晋懿
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