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Composition of medicine for treating diarrhea

A technology for drugs and diarrhea, applied in the field of medicine, can solve the problems of low degree of naturalness, low degree of naturalness, and unfavorable traditional Chinese medicine dripping pill preparations, and can reduce the irritating smell of drugs, improve the pH of the oral cavity, and improve the oral odor. Effect

Active Publication Date: 2006-12-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent
3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug
4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.
[0007] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (a): take Coptidis Rhizoma, Magnolia officinalis, Woody Fragrance, and dried ginger for later use;

[0055] (b): Extract effective active substances from Coptis Rhizoma, Magnolia Officinalis, Woody Fragrance, and Dried Ginger after crushing, wherein Coptidis Rhizome uses ethanol as a solvent, reflux extracts, refines with hydrochloric acid after drying, and obtains Coptis Rhizoma extract; Magnolia officinalis , woody incense, and dried ginger are extracted with supercritical carbon dioxide fluid extraction equipment to extract effective active substances, wherein the extraction pressure of Magnolia Bark Extract is 21-25MPa, the extraction temperature is 35-40°C, and the extraction time is 3-5 hours to obtain Magnolia Bark Extract The extraction pressure of woody oil is 24~28MPa, the extraction temperature is 35~40°C, the extraction time is 3~5 hours, and the extraction pressure of dried ginger oil is 25~29MPa, the extraction temperature is 38~42°C, and the extraction tim...

Embodiment 2

[0057] (a): Take 5 g of Coptidis Rhizoma extract obtained according to the method of Example 1, 5 g of Magnolia officinalis extract, 1 g of woody oil, 1 g of dried ginger oil, 17.3 g of lactitol, and 5.2 g of starch for subsequent use;

[0058] (b): Put lactitol and starch in a container, mix well, heat and melt the mixture at 60-85°C, add fine powder of Coptis chinensis extract and stir evenly to dissolve completely, then add Magnolia officinalis extract, Wood fragrance oil, dried ginger oil, stir evenly, stirring time is 10-30 minutes, keep warm, drip at 60-85°C, drop into the methyl silicone oil with a diameter of 1.1-3.5 mm, drop into 0-18°C , drain the formed dripping pills and wipe off the cooling liquid, pack them after drying, and make 1000 dripping pills.

Embodiment 3

[0060] (a): Take 9.3g of Coptis Rhizoma extract obtained according to the method of Example 1, 9.3g of Magnolia officinalis extract, 4.5g of woody oil, 4.5g of dried ginger oil, 48.75g of xylitol, and 13.25g of gum arabic for subsequent use;

[0061] (b): Mix xylitol and gum arabic in a container, heat and melt the mixture at 60-85°C, add the above-mentioned raw drug powder, mix well, and stir evenly. The stirring time is 10-30 minutes. Dropping at a temperature of ~85 ° C, the diameter of the dropper is 1.2 ~ 2.5 mm, drop into the liquid paraffin at 0 ~ 18 ° C to drain the formed drop pills and wipe off the cooling liquid, and pack them after drying to make 5000 drops Pills, that is.

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Abstract

A medical composition for treating diarrhea is prepared from the extracts of coptis root and magnolia bark, aucklandia root oil and the oil of dried ginger.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical preparation for treating diarrhea made from traditional Chinese medicines. Background technique [0002] Modern epidemiological studies have confirmed that gastrointestinal diseases have become the No. In the past, the elderly or physically weak patients could just take some symptomatic medicines without attracting too much attention, but the consequences caused by gastrointestinal diseases were often very serious. [0003] At present, there is a lack of good medicines for treating both symptoms and root causes of diarrhea. Berberine is currently the most used medicine for acute enteritis. Its bitter and cold products can be used for damp-heat diarrhea. Spleen loses the stomach; Xieliating is the number one antidiarrheal western medicine sold in the retail market, it does not have the effect of dispelling dampness and refreshing the spleen...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/20A61P1/12
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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