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Juglans mandshurica maxim pdysaccharide preparation capable of effectively treating brain cancer and its preapring method

A walnut bark polysaccharide and an effective treatment technology can be applied in the field of medicine, can solve problems such as undiscovered problems, and achieve the effects of no three-waste pollution, suitable for large-scale industrial production, and low toxic and side effects

Inactive Publication Date: 2006-10-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned documents focus on the separation of physiologically active substances of the alcohol extract of Juglans catalpa, and no anti-cancer preparations with Juglans catalpa polysaccharide as the main physiologically active component have been found in further searches, and the aspects of effectively inhibiting the growth of brain tumor cells literature reports

Method used

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  • Juglans mandshurica maxim pdysaccharide preparation capable of effectively treating brain cancer and its preapring method
  • Juglans mandshurica maxim pdysaccharide preparation capable of effectively treating brain cancer and its preapring method
  • Juglans mandshurica maxim pdysaccharide preparation capable of effectively treating brain cancer and its preapring method

Examples

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Effect test

example 1

[0039] Example 1 Preparation of anticancer agents from leaves

[0040] Collection and drying of Juglans material:

[0041] Collect 1 kg of Juglans catalpa leaves in October. First remove impurities, then cut into 1 cm wide strips, and dry in the shade in a ventilated and dry place to obtain 0.2 kg of dried leaves of Juglans catalpa. The dried Juglans catalpa leaves can be stored in a low-temperature dry place for half a year without deterioration.

[0042] Extraction of Anticancer Active Components from Juglans catalpa

[0043] Get 200 grams of the above-mentioned dried Juglans catalpa leaves, add 2 liters of water, heat and keep boiling (100° C.) for 4 hours, then separate the boiling liquid clear liquid and residue by vacuum filtration at 0.8 standard atmospheric pressure. Then add 2 liters of water to heat and boil the Juglans catalpa material residue 2 times according to the same method respectively, and filter and collect the boiling liquid clear liquid. Discard the J...

example 2

[0046] Example 2 Preparation of anticancer agents from tree roots

[0047] Collection and drying of Juglans material:

[0048] Collect 1 kg of Juglans catalpa roots in October, and form strips with a cross-sectional area of ​​about 0.25 square centimeters, with a length of about 2 cm, and then heat and dry at 60 degrees to obtain 0.4 kg of dried Juglans catalpa roots. It can be stored in a dry place at low temperature for half a year without deterioration.

[0049] Extraction of Anticancer Active Components from Juglans catalpa

[0050] 400 grams of dried Juglans bark root, then add 4 kilograms of water, heat to 80 ° C for 4 hours, then separate the boiling liquid clear liquid and residue by vacuum filtration at 0.8 standard atmospheric pressure. Then add 4 kilograms of water to heat and boil the Juglans catalpa material residue 2 times according to the same method, and filter to collect the clear liquid. Discard the Juglans catalpa material residue that has been boiled for...

example 3

[0053] Example 3 Using the preparation of the present invention to improve the survival time of brain tumor experimental mice

[0054] Take 28 experimental mice, half male and half male. Inject 20 microliters of G422 tumor tissue suspension into the brain of each mouse, and the cell density in the suspension is 107 / mL. From the third day of inoculation, each animal was administered three times a day, 2, 5, 10, 15, 20, 25 milliliters at a time, and physiological saline was used as a blank control to observe its survival time.

[0055] Statistics found that the average survival time of mice in the blank control group was 13 days, while the average survival time of the administration group was significantly prolonged, and a case of complete tumor disappearance was observed in the 20 ml administration group.

[0056] control

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Abstract

The present invention relates to a juglans mandshurica polysaccharide preparation for curing brain cancer and its preparation method. The composition of said preparation includes (by wt%) 85-98% of juglans mandshurica polysaccharide and 15-2% of flavone substance. Its preparation method includes the following steps: (1) collecting and drying juglans mandshurica raw material; (2) extracting anticancer active component of juglans mandshurica, including the processes of pulverizing, adding water, heating, separating, filtering, concentrating, drying, pulverizing, sieving so as to obtain active polysaccharide powder; and (3), preparing anticancer decoction.

Description

technical field [0001] The invention relates to a product in the technical field of medicine and a preparation method thereof, in particular to a Juglans polysaccharide preparation capable of effectively treating brain cancer and a preparation method thereof. technical background [0002] The commonly used anticancer drugs at this stage belong to chemotherapy drugs, which are basically western medicines characterized by pure compounds. When these drugs kill cancer cells, they also have a great killing effect on normal human cells, showing different degrees of toxic and side effects. Therefore, looking for anticancer drugs with less toxic and side effects has become a hot research field. Natural medicines, especially botanical medicines, have become the focus of research by researchers at home and abroad. Paclitaxel extracted from yew, vinblastine and vincristine obtained from vinca, camptothecin obtained from camptothecin, and ginkgolide isolated from ginkgo biloba are exa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/352A61P35/00
Inventor 苗志奇于湘莉汪业春苗海彬唐克轩
Owner SHANGHAI JIAO TONG UNIV
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