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Medicine for treating influenza and bird flu

An avian influenza virus, anti-influenza technology, applied in the field of medicine, can solve the problems that do not involve the anti-influenza virus of Mianma Guanzhong

Inactive Publication Date: 2006-10-18
罗定市原始蛋鸡养殖有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lanzhou Foci Pharmaceutical Co., Ltd. Zhu Rongzu and others (patent application number: 03108749.3) use Mianma Guanzhong as the king medicine, combined with Chinese and Western medicines such as Banlangen, wild chrysanthemum, mountain bean root, aspirin, and chlorpheniramine maleate. The compound preparation "Compound Guanzhong Aspirin Tablets" has a significant effect in preventing and treating colds and flu, but the patent does not involve the medicinal ingredients of Mianma Guanzhong anti-influenza virus

Method used

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  • Medicine for treating influenza and bird flu
  • Medicine for treating influenza and bird flu
  • Medicine for treating influenza and bird flu

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of Rhizome Extract

[0026] Take the roots of Mianma Guanzhong, grind them until they pass through a 40-mesh sieve, and extract twice with 80% ethanol aqueous solution under reflux. , ethanol is recovered by volatilization, and the remaining extract is dissolved in an appropriate amount of water. The weight of the aqueous solution is 1.5 times that of the pulp, and it is extracted with ethyl acetate and n-butanol successively, and is extracted 3 times respectively. The aqueous solution is equivalent, and the n-butanol extracts are combined, concentrated by vacuum distillation, evaporated to dryness to recover n-butanol to obtain a paste liquid, dried at low temperature, and pulverized to obtain a reddish-brown or black powder, which is the Guanzhong extract.

experiment example 1

[0027] Experimental Example 1 Medicine of the present invention is effective against chicken intraembryonic influenza virus (H 9 N 2 strain) proliferation inhibition

[0028] 1. Experimental materials

[0029] Avian influenza virus strain: A / Chicken / Guangdong / 3 / 2004 (H 9 N 2 ). Isolation, purification, preservation and identification of the School of Veterinary Medicine, South China Agricultural University. (This virus is a low-pathogenic avian influenza virus. In addition to South China Agricultural University, the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, the Institute of Virology of the Chinese Center for Disease Control and Prevention, and the Virus Preservation Center of the Wuhan Institute of Virology, Chinese Academy of Sciences, etc. The applicant's unit has a production license for the production of H9 subtype avian influenza vaccine (2003 New Veterinary Drug Certificate No. 35) issued by the Ministry of Agriculture. Fo...

experiment example 2

[0047] Experimental example 2 Pharmacodynamics test of the medicine of the present invention to mice artificially infected with influenza virus

[0048] 1. Experimental materials

[0049] Experimental animals: Kunming mice, provided by the Experimental Animal Center of Southern Medical University (Guangzhou).

[0050] Test drug: Guanzhong extract powder, self-prepared, each gram of Guanzhong extract is equivalent to 2.6g crude drug. The medicinal material is Mianmaguanzhong.

[0051] The murine lung-adapted strain of influenza A virus FM1 was obtained from the Institute of Biotechnology, Chinese Academy of Medical Sciences.

[0052] 2. Test methods and results

[0053] 2.1 Acute toxicity test of Guanzhong extract on mice

[0054] 20 Kunming mice, weighing 19-21 grams, were randomly divided into 4 groups, 5 in each group, administered by feeding method. According to the pre-test results, the dosage was designed with a group distance of 2.15 times by Horn's method. The mice...

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Abstract

The present invention provides medicine for treating influenza and bird flu with effective component extracted from basket kern. The present invention proposes the application of basket kern extract in preparing medicine for treating influenza and bird flu for the first time, and provides the high efficiency liquid chromatography-mass spectrography analysis process to constitute the fingerprint of basket fern rhizome extract. The process includes the HPLC-MS analysis condition of basket fern rhizome extract, chromatographic peak characteristic, compound structure information of the chromatographic components, etc. The fingerprint and technology of the present invention may be used in the variety identification of basket fern and the quality control of the basket fern rhizome extract.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine against influenza and avian influenza virus and its preparation and detection method. Background technique [0002] Influenza, referred to as Influenza, is an acute respiratory disease caused by Influenza Virus (IFV) in humans and animals. It has the characteristics of strong infectivity, wide prevalence, high morbidity and mortality. Evidence shows that about 10% of the world's people are infected with the disease during the winter flu outbreak every year, and about 500,000 people die from various flus and complications caused by flus around the world every year. Avian influenza (AI) is a severe poultry infectious disease caused by type A influenza virus, which is extremely harmful to the poultry industry and threatens human life and health. Since December 2003, the highly pathogenic H5N1 subtype avian influenza that first broke out in Asia has spread to many countries and re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K9/08A61K9/10A61K9/20A61K9/48A61K125/00A61P31/16G01N30/02G01N33/15
Inventor 陈建新曾振灵陈杖榴方炳虎邱灵才陈良柱李杰
Owner 罗定市原始蛋鸡养殖有限公司
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