Method for extracting water-soluble saponin from Mexico big peltate yam rhizome

A technology of Dioscorea scutifolia and water-solubility, applied in the field of preparation of steroids, can solve the problems of incomplete removal of sugar and pigment, irritation of mucous membranes of nostrils, unpleasant smell of n-butanol, etc., and achieves easy operation and rich content , The effect of reducing the trouble of operation

Inactive Publication Date: 2006-10-11
广西正鑫生物科技有限公司
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AI Technical Summary

Problems solved by technology

Considering that this method consumes a lot of solvents, the cost is high, and n-butanol has a high boiling point (117°C), making it difficult to recover; the extraction is easy to emulsify, and the removal of sugar and pigment is not complete; The mucous membrane is irritating, and long-term exposure is not conducive to protecting the health of workers

Method used

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  • Method for extracting water-soluble saponin from Mexico big peltate yam rhizome

Examples

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Embodiment 1

[0035] Weigh 50 grams of dried yam yams, crush them with a steel mill, pass through a 40-mesh sieve, put them in a beaker, add normal water (22°C) to 500ml, soak for 12 hours, filter, collect the filtrate, add water to the filter residue to 500ml, soaked for 10 hours, filtered to remove impurities, and the combined filtrate was concentrated to about 600ml. Add 95ml of 95% ethanol, let stand for 12 hours, filter to remove impurities, then add 112ml of 95% ethanol to the filtrate, let it stand for precipitation for 12 hours, filter to remove impurities, add 193ml of 95% ethanol to the filtrate for the third time, let stand for 12 hours, filter to remove impurities miscellaneous. Ethanol was recovered by distillation under reduced pressure, and the extract was further concentrated to 300ml, left to stand for 24 hours, and filtered. The filtrate is dropped into the treated polar AB-8 macroporous adsorption resin column (R50mm, H600mm) for adsorption, first elute with 30% ethanol ...

Embodiment 2

[0038] Weigh 100 grams of dried yam yam mexicanis, crush it into coarse powder, steel mill, add cold water to 1000ml, soak for 24 hours, filter, add the filter residue to 1000ml with cold water, soak for 20 hours, filter to remove impurities, combine the filtrate and concentrate To about 600ml, add 95% ethanol until the alcohol content reaches 85%, let stand for 24 hours, filter to remove impurities. Ethanol is recovered by distillation. And the following procedure is the same as the above example, and finally obtains 15.2 grams of water-soluble total saponins of yam, with a yield of 15.20%.

[0039] The average yield is 15.90%.

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Abstract

The invention discloses a process for extracting water-soluble saponin from Mexican Peltate yam rahizome which comprises, using Mexican Peltate yam rahizome as raw material, comminuting and carrying fine grinding, sieving, deslagging, depositing the filtrate under controlled temperature, concentrating the upper layer liquid, charging ethanol and stewing, filtering and reclaiming ethanol, concentrating, purifying through adsorptive separation, finally concentrating and drying again.

Description

technical field [0001] The invention relates to a preparation method of a steroid compound, in particular to a new raw material source and an extraction method of a steroidal water-soluble saponin, which is a medicine for preventing and treating coronary heart disease and angina pectoris. Background technique [0002] Steroidal saponins are a class of oligoglycosides derived from spirostanes. Mainly distributed in Dioscoreaceae, Liliaceae, Scrophulariaceae, Smilaxaceae, Agaveaceae and other plants, more than 10,000 species have been discovered so far. Steroidal saponins, aglycones obtained by hydrolysis and desugaring, are not only famous as the basic science of natural and semi-synthetic steroid hormones and contraceptives, but also the medicinal value of the saponins themselves has been rapidly developed in the past ten years. develop. Studies have found that certain saponins have activities such as lowering blood fat, lowering blood sugar, anti-cancer, anti-virus, anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/894A61P9/10
Inventor 韦湖田
Owner 广西正鑫生物科技有限公司
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