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Medicinal preparation of coenzyme Q10 liposome and its preparation technology

A technology of pharmaceutical preparations and liposomes, applied in the field of medicine, can solve the problems of inconvenient swallowing and low bioavailability of patients, and achieve the effects of improving therapeutic effect, improving bioavailability and improving compliance

Inactive Publication Date: 2011-07-27
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

current coenzyme Q 10 The oral dosage forms are mainly tablets, capsules, soft capsules, etc. These dosage forms have problems such as inconvenient swallowing and low bioavailability.

Method used

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  • Medicinal preparation of coenzyme Q10 liposome and its preparation technology
  • Medicinal preparation of coenzyme Q10 liposome and its preparation technology
  • Medicinal preparation of coenzyme Q10 liposome and its preparation technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] coenzyme Q 10 50mg, soybean lecithin 300mg, cholesterol 300mg, pH6.5 phosphate buffer 10mL.

[0067] Coenzyme Q 10 , soybean lecithin, and cholesterol in a pear-shaped bottle, add 30 mL of dichloromethane, heat to dissolve, put it on a rotary evaporator, remove dichloromethane under reduced pressure in a water bath at 60°C, add phosphate buffer, continue to rotate for 1 hour, and Extrude through 0.8m filter membrane to get coenzyme Q 10 Liposomal oral solution.

Embodiment 2

[0069] coenzyme Q 10 10mg, egg yolk lecithin 60mg, cholesterol 30mg, Tris buffer solution of pH 7.5 10mL.

[0070] Coenzyme Q 10 , egg yolk lecithin, cholesterol, add 2mL ethanol to dissolve, put Tris buffer in a three-neck flask, inject the lipid solution into the buffer in a water bath at 50°C, and squeeze out through a 0.2m filter membrane to obtain coenzyme Q 10 Liposomal injections.

Embodiment 3

[0072] coenzyme Q 10 15mg, soybean lecithin 100mg, cholesterol 20mg, pH6.7 phosphate buffer 10mL.

[0073] Coenzyme Q 10 , soybean lecithin, and cholesterol were placed in a pear-shaped bottle, added 10 mL of chloroform to dissolve, placed on a rotary evaporator, and decompressed in a water bath at 40°C for 5 minutes until gelatinous, added 10 mL of phosphate buffer, continued to rotate for 1 hour, and Extrude through a 0.45m filter membrane to obtain coenzyme Q 10 Liposome injection.

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Abstract

The invention discloses a pharmaceutical preparation of a coenzyme Q10 liposome and a preparation method thereof. The coenzyme Q10 liposome of the invention is a liquid preparation, comprising the coenzyme Q10, a lipid component and common pharmaceutical accessories. The concentration of the coenzyme Q10 in the liposome is 0.05-50%. Each 10mL of the preparation contains the following components: 5mg-5g of the coenzyme Q10, 4mg-10g of the lipid component, and 10mL of a buffer liquid. The inventive technology solves the stability of the coenzyme Q10 liquid preparation, and improves bioavailability in vivo, realizes a passive target action of the medicine. The pharmaceutical preparation of the invention can be made into a suspension of the coenzyme Q10 liposome for oral or injection. The preparation method of the invention has simple operation and is applicable for industrial production.

Description

technical field [0001] The present invention relates to coenzyme Q 10 A liposome and a preparation method thereof belong to the technical field of medicine. Background technique [0002] coenzyme Q 10 (coenzyme Q 10 , CoQ 10 ) is an endogenous substance in animals. It exists in the inner membrane of mitochondria. It is a hydrogen transporter in the respiratory chain, an activator of cell metabolism, and an essential substance for the human body to maintain life. It passes through the inner membrane of mitochondria in the body. The role of the system is synthesized from p-hydroxybenzoic acid and isopentenyl pyrophospholipids. endogenous coenzyme Q 10 The total content in the human body is 0.5-1.5 mg, and the level in the heart, liver and pancreas is relatively high, and it has the function of binding proteins. Clinical studies have found that exogenous coenzyme Q 10 It has antioxidant and cell membrane stabilizing effects, can maintain the internal and external environ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K9/127A61P9/04A61P9/06A61P9/10A61P9/12A61P1/16A61P1/04A61P11/00A61P35/00
Inventor 邓英杰李喆
Owner SHENYANG PHARMA UNIVERSITY
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