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Prepn process and use in repairing bone defect of calcined bone powder

A technology of calcining bone and calcining, which is applied in the field of preparation of medical and sanitary materials to achieve good biocompatibility and good tissue compatibility

Active Publication Date: 2006-08-02
高心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of calcined bone powder, which solves the problems of antigenicity and biocompatibility of other bone tissue scaffold materials

Method used

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  • Prepn process and use in repairing bone defect of calcined bone powder
  • Prepn process and use in repairing bone defect of calcined bone powder
  • Prepn process and use in repairing bone defect of calcined bone powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Pretreatment of Calcined Bone

[0030] According to the principle that the strength and porosity of the selected bones are basically similar to those of human bones, the one-year-old bovine spine was selected as the object of treatment.

[0031] Cut the freshly sacrificed beef spine into 10mm 3 Small pieces, washed several times with clean water, and then boiled in a pot. The main purpose of this process is to remove the organic matter attached to the beef bones, such as: gelatin, bone marrow, protein, etc. This process takes 4 to 5 hours.

[0032] After the above-mentioned processed bovine bone is dried in a drying oven, the bovine bone is crushed into about 5mm with a pulverizer. 3 Put the small pieces into the pot and cook again to remove most of the organic matter. This process takes about 3 hours to change the water 3 times, and dry it for later use.

[0033] Put the above-mentioned bovine bone into 1M NaOH or sodium bicarbonate solution a...

Embodiment 2

[0037] Preparation method of calcined bone meal

[0038] The prepared bovine bone blocks were put into a high-temperature furnace (model: Tube Furnace 21100, Germany) and calcined at different temperatures. Below only the experimental situation table comparison under different temperatures (see table 1):

[0039] temperature °C

apparent state

physical properties

Processing time (hours)

150

No change in color (white)

no change in intensity

3

250

color starts to turn black

ditto

3

350

color is black

ditto

3

450

ditto

ditto

3

550

light gray

ditto

3

650

color turns white

weakened

3

800

White

ditto

3

[0040] In this experiment, bone powders with different calcination temperatures were compared. When the calcination temperature was 150°C, soft tissue remained in the p...

experiment example 1

[0045] X-ray (Powder) Diffraction Analysis of Calcined Bone Powder

[0046] Instrument model: Rigaku D / max 2500V PC X-ray diffractometer.

[0047] Working conditions: Cu rake, 40kv, 200mA, continuous scanning of the standard sample stage.

[0048] Scanning speed: 4.000deg / min.

[0049] Sample feeding width: 0.020deg.

[0050] Scan axis: 2Theta / thetan.

[0051] Scanning range: 5.000≥60.000deg.

[0052] Carry out X-ray diffraction analysis to the calcined bone meal of the present invention, its composition is as a result figure 1 shown.

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Abstract

The preparation process and use in repairing bone defect of calcined bone powder as one rack material to induce the regeneration of bone tissue is disclosed. The calcined bone powder has obvious bone healing promoting effect, relatively high biocompatibility, certain hardness and strength, easy shaping and rich material source, and thus facilitates the preparation of artificially synthetic material with required porosity, pore communication, pore size, etc.

Description

technical field [0001] The invention relates to a preparation method of a scaffold material for guiding bone regeneration, in particular to a preparation method of calcined bone powder and its application in bone defect repair, belonging to the field of preparation of medical sanitary materials. Background technique [0002] Due to the limitation of the application of autologous bone graft and allogeneic bone graft, the repair of bone defect has become a difficult problem in clinical treatment for many years. Replacing the two with artificial materials for clinical application is the main direction of current research in the field of bone transplantation, and it is also the main research content of maxillofacial surgery, restorative surgery, and orthopedic surgery. [0003] At present, there are many kinds of scaffold materials used in bone tissue engineering. Although each has its own advantages, all of them have insurmountable deficiencies, which limit the development of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38
Inventor 高心何钟勤
Owner 高心
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