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Six-dimensional lecithoid soft capsule identification method and content determination method

A technology of six-dimensional phospholipid and determination method, which is applied in measurement devices, instruments, scientific instruments and other directions to achieve the effect of strong controllability and high accuracy

Inactive Publication Date: 2006-07-26
周有财
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also do not see the report of the content assay method of simple and convenient Liuwei Lecithin Soft Capsules, be badly in need of a kind of easy and easy assay method of Liuwei Lecithin Soft Capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Niacinamide, vitamin B 1 , Vitamin B 2 , Vitamin B 6 Assay method

[0043] Chromatographic conditions and system suitability test use octadecylsilane bonded silica gel as filler; mobile phase is acetonitrile-methanol-water mixture with a weight ratio of 14:6:80, water contains 0.0506% sodium heptanesulfonate and 0.12 % triethylamine, and adjust the pH value to 2.5 with phosphoric acid; the detection wavelength is 273nm. Niacinamide, Vitamin B 1 , Vitamin B 2 , Vitamin B 6 The resolution between the chromatographic peaks is 1.8, and the number of theoretical plates is 1200 based on nicotinamide.

[0044] Preparation of reference solution Accurately weigh about 60 mg of nicotinamide and vitamin B 1 About 12mg, Vitamin B 2 About 12mg, Vitamin B 6 About 12mg, put in a 200ml measuring bottle, add 100ml of ethanol, heat to dissolve, dilute to the mark with mobile phase, shake well, accurately measure 5ml, put in a 50ml measuring bottle, add mobile phase to ...

Embodiment 2

[0074] The content determination method of embodiment 2 vitamin E

[0075] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; methanol-water mixture with a weight ratio of 97:3 is used as mobile phase; detection wavelength is 280nm, and the number of theoretical plates is 3500 based on vitamin E peak .

[0076] The preparation of the reference solution should be protected from light. Accurately weigh an appropriate amount of vitamin E reference substance, add an appropriate amount of methanol to dissolve and dilute to make a solution containing 0.48 mg of vitamin E per 1 ml, as the reference substance solution.

[0077] Preparation of the test solution in the dark. Take an appropriate amount of the content under the difference in loading amount (approximately equivalent to 12 mg of vitamin E), weigh it accurately, place it in a 25ml measuring bottle, add an appropriate amount of methanol to dissolve and dilute to the ...

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Abstract

The invention discloses a method for identifying six-dimensional phosphatide soft capsule and content testing. The method comprises steps of: identifying niacinamide, vitamin B1, vitamin B2, vitamin B6 and vitamin E with high efficiency liquid chromatography; measuring the contents of niacinamide, vitamin B1, vitamin B2, vitamin B6 and vitamin E. The inventive method has the advantages of being accurate and controllable.

Description

technical field [0001] The invention relates to a method for detecting medicines for treating liver diseases. technical background [0002] At present, liver disease is a common and frequently-occurring disease in our country. Excessive drinking and drug abuse lead to an increase in liver diseases year by year. There is an urgent need for clinically effective and safe drugs to relieve the suffering of the majority of patients. [0003] Approved by the National Pharmacopoeia Committee, it is named as Liuwei Phospholipid Soft Capsule, which is a safe and effective drug for liver disease treatment. It is a soft capsule, and the content is a brownish-yellow oily liquid. Each capsule contains 300mg soybean lecithin, 6mg vitamin B 1 , 6 mg vitamin B 2 , 6 mg vitamin B 6 , 26 μg vitamin B 1 , 6mg vitamin E, 30mg niacinamide. The similar product abroad is Gandejian (currently known as Yishanli), a soft capsule produced by A.Nattermann&Cie.GmbH in Germany. [0004] In the Chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86
Inventor 周有财
Owner 周有财
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