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Aliphatic polyester-polyamino acids copolymer with biological function and its synthesis method

A technology of aliphatic polyester and polyamino acid, applied in the field of high molecular polymer biomedical materials, can solve problems such as difficult modification

Inactive Publication Date: 2006-07-12
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This property of RGD prompts people to think of bonding it to synthetic polymers to improve the cell adhesion of synthetic materials, such as bonding to polyvinyl alcohol, polytetrafluoroethylene, polyacrylamide, polyurethane, However, these materials themselves have certain defects in biocompatibility, mechanical strength, etc.
At the same time, aliphatic polyesters are difficult to modify because they do not have functional groups. So far, few people have bonded RGD to polyester materials.

Method used

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  • Aliphatic polyester-polyamino acids copolymer with biological function and its synthesis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of polyethylene glycol-polylactide-polyglutamic acid block copolymer by hydrogenation reduction.

[0030] (1) 0.5g polyethylene glycol-aliphatic polyester-polybenzyl glutamate is dissolved in 15ml of tetrahydrofuran, add 5ml of methyl alcohol and a small amount of acetic acid, then add 0.1g of palladium / carbon (10%) as Catalyst, stirred and reacted for a certain period of time under hydrogen bubbling at room temperature, filtered to remove palladium / charcoal, settled with ether, filtered, and vacuum-dried to obtain the product. The results are shown in Table 1.

[0031] make up

[0032] (2) In the autoclave, add 1g of polyethylene glycol-polylactide-polybenzyl glutamate (DP PEG =16,DP PLA =44,DP PBLG =63), dissolve with 30ml dioxane and 10ml methanol, then add a small amount of acetic acid and 0.2g palladium / carbon (10%) as catalyst, react for a certain period of time at 50 ℃ 2 and 8atm, remove palladium / carbon by filtration, use Diet...

Embodiment 2

[0035] Example 2: Preparation of polyethylene glycol-polycaprolactone-polyglutamic acid block copolymer by hydrogenation reduction.

[0036] A certain amount of polyethylene glycol-polycaprolactone-polybenzyl glutamate was added to the reactor, and other reaction steps were the same as in Example 1 to obtain polyethylene glycol-polycaprolactone-polyglutamate segment copolymers. The yield is above 90%.

[0037] Numbering

Embodiment 3

[0038] Example 3: Preparation of polyethylene glycol-polyglycolide-polyglutamic acid block copolymer by hydrogenation reduction.

[0039] A certain amount of polyethylene glycol-polyglycolide-polyglutamic acid benzyl ester is added in the reactor, and other reaction steps are the same as in Example 1 to obtain polyethylene glycol-polyglycolide-polyglutamic acid (Molecular weight PEG=2000, PGA=1000, PLG=6200) block copolymer. The yield is about 90%.

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Abstract

The invention relates to a fatty group polyester-polyamino acid copolymer with biology function and its synthesis method in the field of macromole biological medicine material technique. The block copolymer comprises: the two block copolymer (A) of fatty group polyester -polyamino acid with biology function and three block copolymer (B), and polyoxyethylene-fatty group polyester-polyamino acid three block copolymer (C). The synthesis method comprises: synthesizing the block copolymer of the carboxylic which is protected by benzyl, doing catalytic reduction to the palladium wood coal or hydrolyzing hydrogen bromide to generate the corresponding polymer with free carboxyl, then using NHS (N- hydroxyl succinimide-sauba) to active the flank carboxyl of the polyamino acid section, reacting it with short peptide, sugar or drug with RGD to obtain the fatty group polyester-polyamino acid copolymer with biology function.

Description

technical field [0001] The invention relates to a method for synthesizing aliphatic polyester-polyamino acid block copolymers with biological functions, and belongs to the technical field of high molecular polymer biomedical materials. technical background [0002] Aliphatic polyesters, such as polylactide (PLA), polyglycolide (PGA), and polyε-caprolactone (PCL), are a class of biodegradable polymer materials widely used at present. Aliphatic polyester has low immunity and good biodegradability and biocompatibility, so it is widely used in the fields of biomedicine and medicine, such as: fracture fixation materials, surgical sutures, tissue engineering scaffolds, drug sustained release carriers Wait. However, their affinity and binding ability with cells often cannot meet the requirements of use. At present, various methods such as polymer design, modification and coupling of biologically active substances have been adopted to improve the compatibility of aliphatic polyest...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G63/91C07K17/08A61K31/715A61K47/48A61P35/00A61K47/64
Inventor 景遐斌邓超陈学思田华雨孙静
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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