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Anti-cold nasal administration composition

A technology for nasal administration and composition, which is applied in the field of anti-cold nasal administration composition, which can solve the problems of slow drug effect, achieve the effects of convenient administration, increase bioavailability, and avoid damage

Inactive Publication Date: 2006-03-08
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ① After oral administration, most drugs are enzymatically hydrolyzed by the gastrointestinal tract and first-pass metabolized by the liver, resulting in slow drug efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.5g EDTA-2Na, 2g Xinjieermi and dissolve in water, dissolve 10g Kabobo in the above solution, fully swell for later use, and dissolve 10g pseudoephedrine hydrochloride, 2g chlorpheniramine, 10g ribavirin in an appropriate amount of In water, add it to the above Kappa wave and mix evenly, add 10g of triethanolamine under continuous stirring, adjust the pH to 6.5-7.5, and finally add water to 1000g to get a transparent gel, immediately pack it into a sealed, avoid Store in a cool place in a light container.

Embodiment 2

[0027] Take 1g of chlorobutanol and dissolve it in an appropriate amount of distilled water, add 20g of pseudoephedrine hydrochloride, 5g of chlorpheniramine, 30g of ribavirin, 5g of sodium chloride, and 5g of levofloxacin to dissolve, make up to 1000g with distilled water, mix well, filter, Mix well, pack into nasal drops.

Embodiment 3

[0029] Take an appropriate amount of distilled water, stir and dissolve 30g pseudoephedrine hydrochloride, 10g chlorpheniramine, 20g amantadine, 5g sodium chloride, finally add 20g glycerin, 1g chlorobutanol, stir well, prepare a certain concentration of liquid medicine, filter, Add distilled water to 1000g, stir well, adjust the pH to 6.5-7.5, and distribute it in miniature nasal spray plastic bottles to obtain nasal aerosol.

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PUM

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Abstract

The present invention relates to a nasal medication composition for relieving common cold symptom and inhibiting common cold virus. Said composite is made up by using (by wt%) 0.1%-60% of pseudoephedrine hydrochloride, 0.2%-30% of chlorphenamine and 0.1%-75% of ribavirin.

Description

technical field [0001] The invention relates to an anti-cold nasal administration composition for relieving cold symptoms and inhibiting cold viruses. Background technique [0002] Flu is a kind of common disease and frequently-occurring disease, is divided into viral flu and bacterial flu customarily. Clinically, the vast majority of cases are viral influenza, mainly manifested as sneezing, nasal congestion, runny nose, dry throat and other symptoms; or accompanied by headache, body aches and weakness, loss of appetite, fever, chills and other systemic symptoms. Therefore develop a new cold medicine with definite curative effect and easy to use, and the market prospect is better. [0003] Based on the characteristics of colds, the main therapeutic function of the present invention is to relieve cold symptoms, such as nasal congestion, runny nose, and sneezing; and to suppress cold viruses. [0004] Cold is a common disease, whether it is children, adults, or the elderly, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/00A61K9/12A61K9/06A61K9/14A61P31/00A61P11/00A61K31/4402A61K31/137
Inventor 王京昆孙敏韩黎明彭红琼徐榕雪
Owner YUNNAN INST OF MATERIA MEDICA
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