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Diammonium glycyrrhizate oral cavity disintegrating agent and its preparation method

A technology of diammonium glycyrrhizinate and oral disintegration, applied in the directions of pill delivery, antiviral agents, pharmaceutical formulations, etc., can solve the problems of poor taste, slow absorption, inconvenient swallowing, etc., and achieve timely treatment, rapid disintegration, and taste. good effect

Inactive Publication Date: 2005-08-10
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Diammonium glycyrrhizinate is currently available in oral capsule preparations. For the elderly and children, this preparation has the disadvantages of inconvenient swallowing, poor taste and slow absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of 50 mg Diammonium Glycyrrhizinate Orally Disintegrating Tablets by Direct Compression

[0036] Element

[0037] mint flavor

[0038] Preparation method: Pass the drug and auxiliary materials through 80-mesh sieve respectively, mix evenly, and directly compress the powder into tablets. The prepared orally disintegrating tablet has a smooth and glossy appearance, good taste, and disintegrates rapidly in the oral cavity for 30 seconds. The hardness of the tablet is 2.5 to 3.0 kg, and the dissolution test is performed with neutral phosphate buffer solution, and it dissolves at 37°C within 30 minutes. The amount is 87.54%.

Embodiment 2

[0040] Preparation of 100mg Diammonium Glycyrrhizinate Orally Disintegrating Tablets by Direct Compression

[0041] Element

[0042] The preparation method is the same as in Example 1. The prepared orally disintegrating tablet has a smooth and shiny appearance, good taste, and disintegrates rapidly within 45 seconds. The hardness of the tablet is controlled at 2.5-3.0 kg. The dissolution rate is 91.21% within 30 seconds with a neutral solution.

Embodiment 3

[0044] Preparation of 150mg Diammonium Glycyrrhizinate Orally Disintegrating Tablets by Direct Compression

[0045] Element

Weight percent (mg / mg)

Amount / tablet (mg)

Diammonium glycyrrhizinate

33.3

150

Mannitol

58.7

264.15

Croscarmellose Sodium

6.0

27.0

[0046] citric acid

0.5

2.25

Micropowder silica gel

1.0

4.5

Magnesium stearate

0.5

2.25

mint flavor

0.002

0.009

Total

about 100%

about 450

[0047] The preparation method is the same as in Example 1.

[0048] The obtained orally disintegrating tablets were smooth and glossy, with good taste and rapid disintegration within 45s. The hardness of the tablets was controlled at 2.5-3.0kg, and the dissolution rate was 85.68% in 37°C water after 30s of dissolution test.

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PUM

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Abstract

An orally disintegrating tablet of diammonium glycyrrhetate is proportionally prepared from diammonium glycyrrhetate and them edical auxiliary composed of filler, disintegrant, effervescent agent, lubricant and flouring.

Description

Technical field: [0001] The invention relates to an orally disintegrating preparation of diammonium glycyrrhizinate. The preparation is composed of diammonium glycyrrhizinate as a pharmaceutical active ingredient and pharmaceutical auxiliary materials, wherein the pharmaceutical auxiliary materials are fillers, disintegrants, effervescent agents, lubricants, corrective agents odorant. Background technique: [0002] Orally disintegrating tablets are a new pharmaceutical preparation, the English name is "Orally disintegrating tables". The US FDA has approved this dosage form for marketing on the grounds that it is convenient for certain groups of people to use it, such as the elderly, children, patients with difficulty swallowing or patients in special circumstances. [0003] Definition of orally disintegrating tablet: A tablet that disintegrates or dissolves in the oral cavity without the need for water. Technical requirements: ①It should disintegrate quickly in the oral ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/704A61P1/16A61P31/14
Inventor 蔡金巧
Owner FUKANGREN BIO PHARMA
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