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Medicine composition for treating upper respiratory tract infection and its prepn process

A technology of upper respiratory tract and composition, which is applied in the field of pharmaceutical composition for treating upper respiratory tract infection and its preparation, which can solve the problems of inconvenient use of injections, inconvenient carrying of oral liquids, and prone to allergic reactions, etc. , Low production cost, good dispersion effect

Active Publication Date: 2005-07-13
HAINAN SIMCERE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many traditional Chinese medicine Yinhuang preparations for the treatment of upper respiratory tract infections, including oral liquid, granules, buccal tablets, capsules, buccal tablets, tablets, and injections, which are used to treat upper respiratory tract infections, acute and chronic tonsillitis and acute and chronic Pharyngitis, clinical trial data fully prove that it has a good curative effect (Ji Qiuhong et al. Yinhuang oral liquid in the treatment of upper respiratory tract infection in children. Zhongyuan Medical Journal, 2000 09; Wan Jinzhou. Fang Haiyan. Xiong Jiulin. Yinhuang oral liquid anti The role of viruses. Time diagnosis of Chinese medicine and Chinese medicine, 1977, 02 issue), but there are still many shortcomings in the above dosage forms, which cannot fully meet the clinical needs, such as injections are inconvenient to use and prone to allergic reactions; oral liquids are inconvenient to carry; tablets, Capsules have disadvantages such as low bioavailability and slow disintegration speed; buccal tablets and buccal tablets are difficult for patients to accept because of the bitter taste of baicalin and bad taste.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription: Honeysuckle extract 10g, Scutellaria baicalensis extract 4g, crospovidone 6g, silicon dioxide 0.5g, microcrystalline cellulose 2.2g, talcum powder 0.7g, sodium carboxymethyl starch 2g, magnesium stearate 0.32g , stevia 0.3g;

[0032] Preparation method: mix the powder of honeysuckle extract and baicalin extract with microcrystalline cellulose, sodium carboxymethyl starch, and crospovidone, then add silicon dioxide, magnesium stearate, etc., mix and directly compress into tablets. Promptly get the drug dispersible tablet of the present invention.

[0033] The obtained dispersible tablets have the following characteristics:

[0034] Uniformity of dispersion: in accordance with the provisions of the Pharmacopoeia, in water at 20°C ± 1°C, it should be completely disintegrated within three minutes and pass through the No. 2 sieve.

[0035] powder direct compression

Embodiment 2

[0037] Prescription: Honeysuckle extract 8g, Scutellaria baicalensis extract 8g, crospovidone 4g, silicon dioxide 0.3g, microcrystalline cellulose 1.5g, talcum powder 0.3g, sodium carboxymethyl starch 3g, magnesium stearate 0.1g , stevia 0.15g;

[0038] Preparation method: mix the powder of honeysuckle extract and baicalin extract with microcrystalline cellulose, sodium carboxymethyl starch, and crospovidone, then add silicon dioxide, magnesium stearate, etc., mix and directly compress into tablets. Promptly get the drug dispersible tablet of the present invention.

[0039] The obtained dispersible tablets have the following characteristics:

[0040] Uniformity of dispersion: in accordance with the provisions of the Pharmacopoeia, in water at 20°C ± 1°C, it should be completely disintegrated within three minutes and pass through the No. 2 sieve.

[0041] powder direct compression

Embodiment 3

[0043] Prescription: Honeysuckle extract 7g, Scutellaria baicalensis extract 2.5g, crospovidone 8g, silicon dioxide 0.7g, microcrystalline cellulose 4g, talcum powder 0.8g, sodium carboxymethyl starch 3g, magnesium stearate 0.42g , stevia 0.5g;

[0044] Preparation method: mix the powder of honeysuckle extract and baicalin extract with microcrystalline cellulose, sodium carboxymethyl starch, and crospovidone, then add silicon dioxide, magnesium stearate, etc., mix and directly compress into tablets. Promptly get the drug dispersible tablet of the present invention.

[0045] The obtained dispersible tablets have the following characteristics:

[0046] Uniformity of dispersion: in accordance with the provisions of the Pharmacopoeia, in water at 20°C ± 1°C, it should be completely disintegrated within three minutes and pass through the No. 2 sieve.

[0047] powder direct compression

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Abstract

The present invention relates to medicine composition and its preparation process, and is especially dispersing tablet prepared with honeysuckle extractive and skullcap root extractive, disintegrating agent and pharmaceutically acceptable supplementary material and for treating upper respiratory tract infection, acute and chronic tonsillitis and acute and chronic pharyngitis and its preparation process. The dispersing tablet contains chlorogenic acid 1-5 mg and baicalin 15-50 mg each. The dispersing tablet is taken orally and disintegrated in stomach into homogeneously dispersive fine particles and has fast medicine leaching and absorption, high bioavailability and convenient taking.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating upper respiratory tract infection and a preparation method thereof, in particular to a pharmaceutical composition prepared from honeysuckle extract and scutellaria baicalensis extract, which belongs to the field of traditional Chinese medicine. Background technique [0002] Upper respiratory tract infection is a general term for acute inflammation of the nasal cavity, pharynx or larynx. It is highly contagious and has a high incidence rate. The disease can occur in four seasons and at any age, and it can be transmitted by virus-containing droplets, droplets, or contaminated utensils. Often when the body's resistance is reduced, such as cold, fatigue, rain, etc., the pathogens already exist or the viruses and bacteria invaded by the outside world will grow and reproduce rapidly, leading to infection. Acute tonsillitis is an acute infectious inflammation of the tonsils. It is called "rot...

Claims

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Application Information

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IPC IPC(8): A61P11/00
Inventor 阳向波谢炜范媛媛何捷张媛
Owner HAINAN SIMCERE PHARMA CO LTD
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