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Preparation process of Tibet capilary artemisia

A preparation process and injection technology, which is applied in the field of water injection and freeze-dried powder injections of Capillary chinensis, can solve problems such as the formal production and use of products that have not yet formed a large scale, and the difficulty of removing protein and fiber, and overcome the instability of active ingredients, The active ingredient is stable and the effect is reproducible

Inactive Publication Date: 2005-07-06
BEIJING PULANTE PHARMA SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All kinds of oral solid preparations developed with Tibetan Yinchen as single or compound preparations have applied for patents and formed industrialized products [2，3] (2. Ding Jingye, etc., Extraction process, equipment and production method of Tibetan capillary active ingredients, 1992, Chinese patent application number 92108869, 3, Qinghai Provincial Department of Health, Qinghai Provincial Drug Standards, 1992, 65-67) its curative effect It has been confirmed by a large number of clinical trials. However, due to the difficulty of alcohol extraction and water precipitation in the traditional injection injection extraction process of traditional Chinese medicine, or the removal of protein and fiber in the water extraction and alcohol precipitation method, some chemical components have been precipitated for a long time due to the injection dosage form made of Yin Chen. and other process constraints [4] (4, Zhao Xinxian, Traditional Chinese Medicine Injection, 1998, 146-168), so far no scale products have been formally produced and used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Weigh and wash 1Kg of the whole plant of Swertia chinensis (S.mussotii) in western Sichuan, crush it (≤3mm), add 5000ml of 50% ethanol solution, extract under reflux at 70°C, filter the extract, and repeat the above steps 2-3 Once, the extracts were combined, concentrated to 1000ml, refrigerated at 0°C±1°C for 24 hours, the refrigerated liquid was centrifuged with a high-speed centrifuge, the centrifuged supernatant was collected, ultrafiltered, the molecular weight cut-off of the filter membrane was 10000, the filtered part was retained, and 0.5 -1% activated carbon, heat to remove heat source, add water for injection to 1000ml, filter with microporous membrane, fill, sterilize to make injection water injection.

Embodiment 2

[0017] Embodiment 2: Weigh 1 kg of the whole plant of Swertia franchetiana (S.franchetiana) after cleaning, cut into inch sections, add 5000ml of 50% ethanol solution, extract under reflux at 70°C, filter the extract, repeat the above steps 2- 3 times, combine the extracts, concentrate to 800ml, refrigerate at 2°C±1°C for 24 hours, centrifuge the refrigerated liquid with a high-speed centrifuge, collect the centrifuged supernatant, ultrafilter, the molecular weight cut-off of the filter membrane is 10000, keep the filtered part, add 0.5-1% activated carbon, heat to remove heat source, add water for injection to 1200ml, filter with microporous membrane, fill, sterilize to make injection water injection.

Embodiment 3

[0018] Example 3: The preparation method of the freeze-dried powder injection of Yinchen chanterelles: take the solution to be filled after removing the heat source in Example 1, add 10g of mannitol and water for injection to 1000ml, filter with a microporous membrane, fill, freeze-dry, Made into freeze-dried powder.

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PUM

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Abstract

The invention discloses a process for preparing freeze-drying injection for treating various hepatitis, cholecystitis, liver damage, liver fibrosis, and fatty liver. The invention is prepared from Tibetan mecidicinal herbal oriental wormwood through the steps of, charging water or hydrophilic dissolvent into dried plant powder, backflow extracting through hot dipping, freezing, (2) high speed centrifugation edulcoration, passing the supernatant fluid through ultrafiltration membrane or hollow fiber hyperfiltration columns, entrapping the medicine-containing solution, (4) formulating water injection, and charging freezing support bracket to obtain the dried power injection.

Description

technical field [0001] The invention relates to a process method of water injection injection and freeze-dried powder injection of Tibetan capillary for the treatment of liver and gallbladder system diseases. Background technique [0002] Tibetan Yinchen is a traditional medicinal material used in Tibetan medicine to treat various diseases such as hepatitis, cholecystitis, liver injury, liver fibrosis, and fatty liver. It belongs to the Gentianaceae Swertia plant. A large amount of research data shows that the known chemical components in this type of plant are triterpenoids mainly composed of oleanolic acid, picrosides mainly composed of swertiamarin, swertiaroside and gentiopicroside, The main flavonoids are flavins. Mangiferin-based ketone glycosides [1] (1. Song Wanzhi, Chinese Gentiana plant overview, Chinese Medicine Bulletin, 1986, 11 (11) 643-647), the above ingredients have the ability to reduce transaminase, analgesia, anti-inflammatory, Promoting liver cell rege...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61P1/16A61P31/14
Inventor 易寄东李建中
Owner BEIJING PULANTE PHARMA SCI & TECH DEV
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