Novel medicine for treating malaria controlling malaria spreading

A malaria and new drug technology, applied in the field of new drugs to treat and block the spread of malaria and control the spread of malaria, to achieve rapid control of malaria spread, convenient administration, and strong killing effect

Inactive Publication Date: 2005-05-18
广州青蒿医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of artemisinin or derivatives and ultra-low doses of primaquine to treat and block malaria transmission has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Compatibility of A and D A:D=15:0.5

[0018] For example, 270 mg of artemisinin and 9 mg of primaquine phosphate (substrate), with excipients such as hydroxypropyl cellulose, are made into tablets.

Embodiment 2

[0020] Compatibility of B and D B: D = 150: 0.6

[0021] For example, artesunate 200mg, mefloquine 1250mg and primaquine phosphate (substrate) 6mg, excipients such as hydroxypropyl cellulose, etc., made into tablets.

Embodiment 3

[0023] Compatibility of C and D C:D=129:1

[0024] For example, artesunate 360mg, sulfadoxine 1500mg, pyrimethamine 75mg, primaquine phosphate (substrate) 15mg, the first three are mixed and added with excipients to make tablets, and then combined with split primaquine phosphate tablets Packed on the same aluminum-plastic plate.

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PUM

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Abstract

The medicine for treating malaria and controlling malaria spreading consists of artemisinin or its derivative, or the mixture of artemisinin or its derivative and antimalarial agent with long or medium half life, or separated packed artemisinin or its derivative and antimalarial agent with long or medium half life, in 1-500 weight portions; and lower dosage of primaqine or its salt in 0.1-1 weight portions. Clinical experiment shows that the medicine has the features of high and fast curative effect, low toxicity, short treating period, convenient taking and fast killing gametophyte to block the spreading of malaria.

Description

Technical field [0001] The invention relates to medicine, especially a new medicine for treating and blocking malaria transmission and controlling malaria epidemic. Background technique [0002] The medicines for treating malaria in the prior art are ineffective against the middle and late gametocytes of Plasmodium; while the conventional dose of primaquine phosphate can kill the gametocytes, but its side effects are large, and it is easy to cause hemolysis in patients, especially for those lacking G-6-PD patient. The use of artemisinin or derivatives and ultra-low doses of primaquine to treat and block the spread of malaria has not been reported yet. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a new drug that can quickly and powerfully kill gametocytes at each stage, prevent hemolysis after taking it, block malaria transmission and control malaria epidemic. [0004] The purpose of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/357A61K45/06A61P33/06
CPCY02A50/30
Inventor 李国桥陈沛泉宋建平谈博
Owner 广州青蒿医药科技有限公司
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