Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Efferverscent tablets containing troxerutin and their preparation

A technology for troxerutin and effervescent tablets, which is applied in the field of effervescent tablets containing troxerutin and its preparation, can solve the problems of inability to use and inconvenient application, and achieve fast onset of action, easy storage, and easy demoulding Effect

Inactive Publication Date: 2005-05-11
邱学良
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Troxerutin injection, especially intravenous injection, must be carried out in hospitals and clinics under the operation of medical staff, which is inconvenient to apply, and it cannot be used on the road, and injection, especially intravenous injection, must be prepared during the preparation process. very strict requirements

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Recipe (1000 tablets)

[0032] Troxerutin 0.9 kg (a Troxerutin effervescent tablet contains Troxerutin 900 mg)

[0033] 3.32 kg of anhydrous citric acid (equivalent to 60.7% of the weight of a troxerutin effervescent tablet)

[0034] 1.25 kilograms of sodium bicarbonate (equivalent to 22.85% of the weight of a troxerutin effervescent tablet).

[0035] Mix 0.9 kg of troxerutin, 3.32 kg of anhydrous citric acid, and 1.25 kg of sodium bicarbonate in a container for 30 minutes, transfer to a tablet press equipped with a 5 / 4-inch flat punch, and compress 3 / 8-inch The large pieces are granulated through a 16-mesh sieve, mixed for 5 minutes, and pressed into tablets.

Embodiment 2

[0037] Recipe (1000 tablets)

[0038] Its formula and preparation method are basically the same as Example 1, except that 0.04 kg of troxerutin (equivalent to a troxerutin effervescent tablet contains 40 mg of troxerutin), 3.30 kg of anhydrous citric acid (equivalent to a tablet 66.13% of the troxerutin effervescent tablet weight, after the troxerutin effervescent tablet generated by 1.65 kilograms of potassium bicarbonate (equivalent to 33.07% of a troxerutin tablet weight) is dissolved in water, the generated solution The pH value is 4.2.

Embodiment 3

[0040] Recipe (1000 tablets)

[0041] Troxerutin 300 grams (equivalent to a Troxerutin effervescent tablet contains Troxerutin 300 mg),

[0042] 170 grams of anhydrous citric acid (equivalent to 22.34% of the weight of a troxerutin effervescent tablet),

[0043] 120 grams of sodium bicarbonate, 100 grams of potassium bicarbonate, a total of 220 grams (equivalent to 28.91% of the weight of a troxerutin tablet);

[0044] 50 grams of binder glycine (equivalent to 6.57% of a troxerutin effervescent tablet weight),

[0045] 6 grams of sweetener protein sugar (equivalent to 0.79% of the weight of a troxerutin effervescent tablet),

[0046] Lubricant polyethylene glycol-4000, 15 grams (equivalent to 1.97% of the weight of one troxerutin effervescent tablet).

[0047] Prepare materials according to the amount of each component required above, dry 300 grams of troxerutin and 170 grams of anhydrous citric acid at a temperature of 60°C, grind them into powder, pass through a 100-mesh ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An effervescent tablet for treating cerebrovascular disease is prepared from troxerutin, pharmacologically acceptable acid-base pairs, filler, adhesive, lubricant, sweetening agent and flavouring through proportional mixing, punching to become wafers, granulating, mixing and tabletting. Its advantage is quickly taking its effect.

Description

1. Technical field [0001] The invention relates to a medicament characterized by a special physical shape and a preparation method, more specifically an effervescent tablet containing troxerutin and a preparation method. 2. Background technology [0002] Troxerutin, also known as Troxerrutin, Trihydroxyethylrutoside, and Venoruton, is a derivative of rutin (also known as Rutoside). Flavonoids. The main pharmacological effects include reducing capillary fragility and permeability, anti-virus, anti-inflammatory, analgesic, and improving microcirculation. [0003] Troxerutin is a drug mainly used for the treatment of cardiovascular and cerebrovascular diseases. It can inhibit erythropoiesis and platelet aggregation and prevent thrombosis. Resistance, reducing capillary permeability, can prevent edema caused by increased vascular permeability. It has a significant protective effect on acute ischemic brain injury. It is suitable for the treatment of hemiplegia, aphasia and pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K9/46A61K31/352A61P7/02A61P9/00A61P9/10
Inventor 邱学良权奇哲张冬平崔永南
Owner 邱学良
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com