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Preparing method for collagen stroma composite medical fibre spinning stoste

A technology of spinning stock solution and collagen, which is applied in the fields of cellulose/protein conjugated artificial filament, medical science, prosthesis, etc., to achieve the effect of being easy to accept, easy to meet the process conditions, and good fiber background color

Inactive Publication Date: 2005-02-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on the production of medical fibers from animal skin collagen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Raw material preparation: select 30-120Kg healthy pigs, slaughter, peel, scrape oil, and refrigerate for later use.

[0036] (2) Cleaning: Take 100Kg of refrigerated pigskin, put it into the drum, add 3.0Kg of Pingpingjia, 200Kg of normal temperature water, and 5.0Kg of NaCl, cover the drum door, rotate for 120min, control the waste liquid, add 200Kg of normal temperature water, and rotate for 120min , Control dry waste liquid.

[0037] (3) Shearing: Use a shearing machine or manually cut off the hair on the pigskin.

[0038](4) Degreasing: Take 100Kg of pigskin that has been sheared and put in CO 2 In the supercritical fluid processor, add Na 2 CO 3 3.0Kg, penetrating agent JFC 0.5Kg, rotate for 90min, add Pingpingjia 2.0Kg, degreaser PT-101 2.0Kg, washing powder 2.0Kg, rotate for 90min, control dry waste liquid.

[0039] (5) Cleaning: Put the degreased pigskin into the drum, add 200Kg of hot water at 32°C, rotate for 120min, and dry the waste liquid, then add ...

Embodiment 2

[0045] (1) Raw material preparation: Select 30-60Kg healthy goats, slaughter, peel, scrape oil, and refrigerate for later use.

[0046] (2) Cleaning: Take 100Kg of refrigerated goat skin, put it into the drum, add 16.0Kg of Pingpingjia, 500Kg of normal temperature water, and 17.0Kg of NaCl, cover the drum door, rotate for 180min, control the waste liquid, add 500Kg of normal temperature water, and rotate for 180min , Control dry waste liquid.

[0047] (3) Shearing: Use a shearing machine or manually cut the hair on the goat skin.

[0048] (4) Degreasing: Take 100Kg of goatskin that has been sheared, and put it into CO 2 In the supercritical fluid processor, add Na 2 CO 3 8.0Kg, penetrating agent JFC 1.5Kg, rotate for 120min, add Pingpingjia 6.0Kg, degreaser PT-101 8.0Kg, washing powder 5.5Kg, rotate for 120min, control dry waste liquid.

[0049] (5) Cleaning: Put the degreased goatskin into the drum, add 500Kg of hot water at 36°C, rotate for 180min, and dry the waste liqu...

Embodiment 3

[0055] (1) Raw material preparation: Select 30-120Kg healthy cattle, slaughter, peel, scrape oil, and refrigerate for later use.

[0056] (2) Cleaning: Take 100Kg of refrigerated yellow cowhide, put it into the drum, add 30.0Kg of Pingpingjia, 800Kg of normal temperature water, and 30Kg of NaCl, cover the drum door, rotate for 240min, control the waste liquid, add 800Kg of normal temperature water, and rotate for 240min, Drain waste.

[0057] (3) Shearing: Use a shearing machine or manually cut the hair on the yellow cowhide.

[0058] (4) Degreasing: Get 100Kg of yellow cowhide that has been cut, put into CO 2 In the supercritical fluid processor, add Na 2 CO 3 15.0Kg, penetrating agent JFC 2.0Kg, rotate for 240min, add Pingpingjia 10.0Kg, degreaser PT-101 15.0Kg, washing powder 10.0Kg, rotate for 240min, control the waste liquid.

[0059] (5) Cleaning: Put the degreased animal skin into the drum, add 800Kg of hot water at 40°C, rotate for 240min, and dry the waste liquid,...

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Abstract

This invention publishes a plug-anlage complex medical fibre. Choose healthy animals, after butcher, decorticate, wash and degrease the peltry. Then, hydrolyze and purify it by using the complex enzym-skin glue disposer and chemical substance. Let it receive animal skin glue with good biology consistence and biology activity. Hydrolyzed animal skin glue can gain glue anlage complex medical fibre filature original liquid when mixed with shell-polysacharide after ulteriorly purification. The original liquid can be used to make biology medical velum, operation medical suture and glue-anlage complex medical fibre original liquid.

Description

1. Technical field [0001] The invention relates to a preparation method of a collagen-based composite medical fiber spinning stock solution, which belongs to the field of biomedical materials. 2. Background technology [0002] Collagen exists widely in animals and is the main component of structural tissues in mammals, constituting about 30% of the protein in the human body. Collagen has unique physical and chemical properties, excellent biocompatibility, bioactivity and degradability, low immunity and hemostatic function, and is easily absorbed in the body, strong hydrophilicity, non-toxic and side effects, and safe Well, thus, is regarded as one of the most promising natural biomedical materials. [0003] For a long time, people have used the performance characteristics of animal dermis collagen to research and develop a series of collagen-based biomedical materials, such as biological dressings, artificial skin, biomedical membranes, hemostatic sponges, etc. However, the...

Claims

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Application Information

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IPC IPC(8): A61L27/50D01F8/02
Inventor 但卫华周文常曾睿林海但年华陈弛
Owner SICHUAN UNIV
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