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Method for preparing cardiovascular drug eluting stent

A drug coating and cardiovascular technology, which is applied in the direction of drug devices, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problem that the coating is easy to fall off, so that it is not easy to fall off, improves the infiltration and spreadability, improves the uniformity and The effect of binding firmness

Active Publication Date: 2005-01-26
SHANGHAI REBONE BIOMATERIALS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved in the present invention is to disclose a preparation method of a cardiovascular stent with a drug coating on the surface, so as to overcome the defect that the coating is easy to fall off in the prior art

Method used

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  • Method for preparing cardiovascular drug eluting stent
  • Method for preparing cardiovascular drug eluting stent

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Take a 316L stainless steel bracket, clean it ultrasonically with acetone and isopropanol, and dry it. Place the cleaned stent in the plasma chamber and use N 2 to process. The processing conditions are: background vacuum 5.0×10 -3 Pa, RF voltage 200v, bias voltage 100v, gas flow rate 0.30mL / min, processing time 20min. After the above-mentioned treated stent was taken out, it was quickly immersed in a solution containing 0.01 g of paclitaxel, 0.19 g of ethylene-vinyl acetate, and 7.8 g of toluene for 100 seconds, taken out, and dried in vacuum at 60° C. for 20 hours. It can be seen under the SEM microscope that the prepared drug coating thickness is smooth and flat, such as figure 1 .

Embodiment 2

[0029] Take a 316L stainless steel bracket, clean it ultrasonically with acetone and isopropanol, and dry it. The cleaned stent is placed in the plasma cavity, and treated with argon and nitrogen mixed gas plasma. The processing conditions are: background vacuum 5.0×10 -3 Pa, RF voltage 250v, bias voltage 300v, nitrogen: argon = 1:1, gas flow rate 0.40mL / min, processing time 10min. After the above stent was taken out, it was quickly immersed in a solution containing 0.008 g of paclitaxel, 0.16 g of ethylene-vinyl acetate, and 7.832 g of toluene for 30 seconds, taken out, and dried under vacuum at 60° C. for 20 hours. It can be seen under the SEM microscope that the prepared drug coating has a smooth and flat surface, and its appearance is similar to the stent prepared in Example 1.

Embodiment 3

[0031] Take a 316L stainless steel bracket, clean it ultrasonically with acetone and isopropanol, and dry it. Place the cleaned stent in the plasma cavity, and treat it sequentially with argon and nitrogen plasma. Argon gas treatment conditions are: background vacuum 5.0×10 -3 Pa, RF voltage 100v, bias voltage 200v, gas flow rate 0.10mL / min, processing time 5min. The nitrogen treatment process is: back vacuum 5.0×10 -3Pa, RF voltage 340v, bias voltage 200v, gas flow rate 0.30mL / min, processing time 2min. After the above-mentioned stent was taken out, it was quickly immersed in a solution containing 0.016 g of paclitaxel, 0.24 g of propylene-vinyl acetate, and 7.744 g of toluene for 30 seconds, taken out, and dried under vacuum at 60° C. for 20 hours. It can be seen under the SEM microscope that the prepared drug coating has a smooth and flat surface, and its appearance is similar to the stent prepared in Example 1.

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Abstract

A process for preparing cardiovascular stent with a drug coating layer on its surface is disclosed. It includes the steps of: 1. pretreatment for the stent surface by plasma 2. dipping or spraying of the stent surface in routine method by hyperplasia proof drug and coating polymer containing solution The drug coated stent prepared by the present invention can endure long period washing by all kinds of stress and body fluid in the stent transportation and dilation process, with the coating layer not easy to falling off.

Description

technical field [0001] The invention relates to a medical material for interventional therapy, in particular to a preparation method for a stent with a drug coating on the surface for interventional therapy of human coronary heart disease. technical background [0002] The concept of PTCA (Percutaneous transluminal coronary angioplasty, PTCA) was proposed in 1964 and Gruentzing successfully implemented the first case of PTCA in 1977, creating a new era of human interventional cardiology. PTCA is an innovative technique that does not require surgery and bleeding, which can greatly reduce the pain of patients. At that time, due to the limitations of equipment and technical level, the indication was single-vessel coronary artery disease, and the success rate was only 70%. In the 1980s, with the development of catheter technology and the improvement of operating technology, especially the advent of balloon catheters with controllable and movable guide wires, the indications for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61M29/00A61M31/00A61P9/10
Inventor 刘昌胜袁媛
Owner SHANGHAI REBONE BIOMATERIALS
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