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Controlled release preparation for nitrendipine of constant speed release

A technology for nitren and preparations, applied in the field of controlled release preparations, can solve problems such as severe blood pressure fluctuations, high T/P ratio, changes in blood drug concentration, etc. smooth effect

Inactive Publication Date: 2004-09-01
王颖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Scientific research has found that simple high blood pressure can cause damage to organs, but blood pressure fluctuations are especially serious.
Nitrendipine preparations are currently ordinary tablets, which need to be taken three times a day. Although this preparation can achieve the purpose of lowering blood pressure, due to the severe changes in blood drug concentration, the high T / P ratio, severe blood pressure fluctuations, and organ injury

Method used

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  • Controlled release preparation for nitrendipine of constant speed release
  • Controlled release preparation for nitrendipine of constant speed release

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Experimental program
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specific Embodiment

[0008] Specific embodiment, medicine preparation: (mg / tablet)

[0009] Nitrendipine 30, hydroxypropyl methylcellulose 40, calcium hydrogen phosphate 30, sodium alginate 20, magnesium stearate 1% (dry grain weight), appropriate amount of solvent and other auxiliary materials. According to the prepared formula, each raw material was crushed through a 20-mesh sieve, wet granulated, added a solvent to form a ball, loosened after loosening, dried, sieved and granulated, added magnesium stearate, mixed and pressed into tablets. have to. And experiment among Fig. 1, according to Pharmacopoeia in vitro release assay method, survey product in vitro release of the present invention, stripping medium is the artificial gastric juice containing ethanol, takes a sample within the prescribed time, filters and measures absorbance at 238nm. It is found that the nitrendipine controlled-release tablets prepared according to the present invention can basically release at a constant rate and mai...

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Abstract

The invention relates to a controlled release formulation for constant speed releasing Nitrendipine, which comprises Nitrendipine powder core and release control bone matrix and auxiliary materials, wherein the powder core is Nitrendipine, the release control bone matrix is macromolecular polysaccharides and their derivative, the essential constituents of the auxiliary materials are phosphate, aliphatic acid and its salt, the proportion of the Nitrendipine ingredients is, basic remedy : release control bone matrix : phosphate : aliphatic acid and its salt = 1:0.5-7.0:0.1-2.0:1-2.0, the invention can realize constant speed release, thus achieving the goal of smooth hypertension.

Description

technical field [0001] The invention relates to a controlled release preparation of nitrendipine with constant release rate. Background technique [0002] Nitrendipine (nitrendipine) is a second-generation calcium antagonist developed in the 1980s. It is a calcium antagonist that selectively acts on vascular smooth muscle. It has a better selective effect on conical arteries. It can reduce myocardial oxygen consumption and has a protective effect on ischemic myocardium; it can reduce total peripheral resistance and lower blood pressure. Indications for hypertension, especially for hypertensive patients with coronary heart disease. It can be used to treat coronary heart disease and high blood pressure, and can also be used for congestive heart failure. The half-life of nitrendipine is very short. After oral administration of 30 mg, the plasma concentration reaches its peak within 30 minutes. In plasma, its binding rate to plasma protein is about 98%. T 1 / 2 About 2-4 hou...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/4422A61P9/12
Inventor 王颖侯峻冰
Owner 王颖
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