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Bivalent gene engineering vaccine of fowl infectious bursal disease and pasteurellosis

A genetically engineered vaccine and bursal disease technology, which is applied in the field of new bivalent genetic engineering vaccines for avian infectious bursal disease and pasteurellosis, and can solve problems such as virulent dissemination

Inactive Publication Date: 2004-08-25
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it is also possible that the attenuated vaccine has returned to the strong virus, leading to the spread of the strong virus

Method used

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  • Bivalent gene engineering vaccine of fowl infectious bursal disease and pasteurellosis
  • Bivalent gene engineering vaccine of fowl infectious bursal disease and pasteurellosis

Examples

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Embodiment Construction

[0187] Application of the present invention has:

[0188] (1) For the prevention of chicken infectious bursal disease and chicken pasteurellosis. When used for the prevention of chicken infectious bursal disease, it should be induced with lactose according to the aforementioned method, the cells should be collected and washed several times, and then administered by drinking water or subcutaneous injection. The dosage of drinking water is equivalent to 1 / 3 ~ 1 / 2ml of the saturated induction bacteria solution. The dose for subcutaneous injection is equivalent to 1 / 10-1 / 20ml of the saturation-inducing bacteria solution.

[0189] (2) Use the IBDV VP2 gene sequence of the present invention to carry out research and preparation of other genetic engineering vaccines and genetic engineering antigens.

[0190] (3) Available P.multocida C 48-16 The strains are used as live carrier bacteria for other genetic engineering vaccines for research and development.

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Abstract

The present invention discloses an avian infectious cloaced bursa disease and pasteurellosis bivalent gene engineering vaccine, relating to avian gene engineering vaccine. Said new vaccine is a pasteurella multocida C47-16 / p GEX-KG-VP2, CCTCC No:M203056, on pGEX-KG plasmid is connected an infectious cloacal bursa VP2 protein gene, after induced expression said vaccine can be used for immuniza chicken by means of oral administration or injection mode to make chicken body interior produce antibody for resisting infectious cloacal bursa virus, and when a standard strong strain is used to challenge virus, it can provide protection action for chicken. At the same time said carrier bacterium self-body is a safe effective low viulent vaccine strain for preventing pasteurellosis, so that said vaccine strain also can provide protection for resisting avian pasteurellosis.

Description

technical field [0001] The invention relates to a new poultry genetic engineering vaccine. Specifically, it relates to a new bivalent genetically engineered vaccine for avian infectious bursal disease and pasteurellosis. Background technique [0002] Infectious bursal disease virus (IBDV), which belongs to the double-stranded RNA virus family, can cause infectious bursal disease or Gumboro disease in chickens and turkeys. It causes immunosuppression in chickens aged 3 to 12 weeks by destroying B lymphocytes in chicken bursa. [0003] The genome of IBDV consists of two segments of double-stranded RNA. The smaller segment (A) encodes VP1, a dsRNA-dependent RNA polymerase. The larger stretch (B) contains 2 open reading frames. Box 1 codes for the VP5 protein. Box 2 codes for a polyprotein, which can be automatically processed into three viral proteins by proteolytic enzymes, namely: VP2, VP4, and VP3. Among them, VP2 and VP3 are the main structural proteins of the virus. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61K48/00A61P31/04A61P31/14
Inventor 荣俊程太平刘晓娜杨待建邹国林
Owner YANGTZE UNIVERSITY
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