Bulley aconitne transdermal paster
A technology of aconitin and transdermal patch, which is applied in other medical devices, sheet-like delivery, and drug devices, etc., to achieve clear curative effect, good safety, and stable blood drug concentration
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Embodiment 1
[0033] The transdermal patch described in this embodiment is an adhesive skeleton type patch, which is composed of a three-layer structure of a backing layer, a protective layer and a drug-containing adhesive skeleton (that is, a drug reservoir). The materials used in each layer are as follows:
[0034] Backing layer: non-woven fabric
[0035] Protective layer: siliconized paper
[0036] Medicated Adhesive Skeleton: The formula is as follows (100 sticks):
[0037] Acrylic Pressure Sensitive Adhesive 35g
[0038] Coconut 2.5g
[0039] Azone 1.5g
[0040] Preparation process: take the formula amount of fenugreek, acrylate pressure-sensitive adhesive and Azone, add an appropriate amount of ethyl acetate to dissolve, adjust to a suitable consistency, coat on the protective layer, and control the thickness of the coating. Dry at 70°C, cover with a backing layer, and cut into appropriate shapes and sizes.
Embodiment 2
[0042] The transdermal patch described in this embodiment is an adhesive skeleton type patch, which is composed of a three-layer structure of a backing layer, a protective layer and a drug-containing adhesive skeleton (that is, a drug reservoir). The materials used in each layer are as follows:
[0043] Backing layer: non-woven fabric
[0044] Protective layer: polyester film
[0045] Drug-containing adhesive skeleton: the formula is as follows (100 stickers):
[0046] Polyacrylic resin pressure sensitive adhesive 30g
[0047] Aconitine 2g
[0048] Oleic acid 2g
[0049] The formula of polyacrylic resin pressure sensitive adhesive is:
[0050] Polyacrylic resin IV 20g
[0051] Succinic acid 1g
[0052] Dibutyl phthalate 10g
[0053] Acetone 80ml
[0054] Preparation Process:
[0055] 1. Preparation of polyacrylic resin pressure-sensitive adhesive: Dissolve the amount of succinic acid in acetone, then add polyacrylic acid resin and stir to dissolve, and finally add dibut...
Embodiment 3
[0058] The transdermal patch described in this example is an adhesive layer rate-limiting patch, which consists of a backing layer, a protective layer, a drug-containing adhesive skeleton (i.e. drug storage), and a four-layer structure of the adhesive layer. The materials are as follows:
[0059] Backing layer: polyester film
[0060] Protective layer: PTFE film
[0061] Adhesive layer: blank silicone pressure sensitive adhesive
[0062] Drug-containing viscose skeleton: the formula is as follows (100 stickers):
[0063] Silicone pressure sensitive adhesive 30g
[0064] Aconitine 1.0g
[0065] Azone 1.5g
[0066] Preparation Process:
[0067] 1. Preparation of drug-containing skeleton layer: Dissolve silicone pressure-sensitive adhesive, aconitin and Azone in an appropriate amount of ethyl acetate, adjust to a suitable consistency, and coat on the backing layer to control the coating thickness. Dry at 70°C.
[0068] 2. Preparation of adhesive layer: apply blank silicon...
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