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Polyurethane material containing fluorin in its lateral chain and preparing method thereof

A polyurethane material and side chain technology, which is applied in the field of polymer biomedical materials and its preparation, can solve the problems of low molecular weight, poor mechanical properties, and high price of polyurethane, and achieve the effects of high mechanical properties, easy control, and wide application

Inactive Publication Date: 2003-10-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fluorine-containing polyurethane in the hard segment of the main chain mainly uses fluorine-containing small molecule diol as the chain extender of polyurethane, the movement of the fluorocarbon chain is restricted, and the fluorine content on the surface of the material is very low (lower than the bulk fluorine content) [Sung chul Yoon and Buddy D.Ratner.Macromolecules 1986, 19, 1068-1079.Sung chul Yoon and Buddy D.Ratner.Macromolecules 1988, 21, 2401-2404]; the main chain soft segment fluorine-containing polyurethane adopts perfluoropolyether diol as soft segment, the price is very expensive, and the use is limited [C.Tonelli, T.Trombetta, et al., J.Appl.Poly.Sci., 1996, 59, 311-327]; the soft segment side chain fluorine-containing polyurethane usually has mechanical properties Poor, and the fluorocarbon chains are easily rearranged in the aqueous environment in the body, tending to the interior of the material [T.M.Chapman, R.Benrashid, et al., Macromolecules, 1995, 28, 331-335]; while the molecular weight of polyurethane terminated by fluorocarbons Generally lower [Y.W.TANG; et.al.; J.Appl.Poly.Sci.1996, 62, 1133~1145.], poor mechanical properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3 7 10

[0044] These three embodiments all adopt a two-step bulk polymerization or semi-prepolymerization process.

[0045] First, add polycarbonate or polyether glycol into a reaction kettle equipped with a stirrer, thermometer and vacuum device, stir and raise the temperature to 80-100°C, degas under vacuum for 30-60 minutes under stirring conditions, and then lower the temperature to 50- 70℃; Secondly, if the formula has a catalyst, add the catalyst and add the diisocyanate to react for 5-60 minutes. The isocyanate content is measured during the reaction, and the chain extender is added when the isocyanate drops to the theoretical amount, or the isocyanate When the acid radicals have not completely reacted with the hydroxyl groups of the polycarbonate and / or polyether glycol, add a chain extender, continue to stir and raise the temperature to 100~110℃, react for 3~20 minutes; then transfer the reaction mixture to the preheated polycarbonate at 100℃ After curing in a tetrafluoroethylene...

Embodiment 13 15

[0051] The three examples all use the co-solvent blending process.

[0052] Take 30, 60, 70g of the polycarbonate polyurethane of Comparative Example 1 and dissolve them in DAMC, and then add 70g of the fluorine-containing polyurethane prepared in Example 1, 40g of the fluorine-containing polyurethane prepared in Example 4, and fluorine-containing polyurethane prepared in Example 10. 30 g of polyurethane was used as the ratio of Examples 13 to 15. Since the polyurethanes of Examples 1 and 4 are in a solution state, the amount of the polyurethane added should be such that the solid content meets the requirements of the formula. Adjust the solid content of all the examples to 30-40%, and stir at 25-60°C to dissolve all the solid polyurethane to obtain the product.

[0053] Embodiments sixteen to nineteen

[0054] The four embodiments all adopt the twin-screw extrusion blending process.

[0055] Take 95, 80, 25g of the polyether polyurethane pellets of Comparative Example 2, and then...

Embodiment 13

[0061]Mpa% Mpa% Mpa% Example 1 56.3 340 55.8 350 56.1 330 Example 2 48.2 400 46.1 420 47.0 390 Example 3 57.3 320 56.0 316 54.5 309 Example 11 40.2 270 37.6 260 38.7 250 Example 7 28.6 660 28.4 650 26.5 610 Comparative Example 1 58.5 340 30.6 280 39.2 300 Comparative Example 2 40.3 650 36.7 580 / / Example 13 55.1 350 53.5 334 54.5 342 Example 16 35.8 640 34.6 632 33.2 600

[0062] Table 2 Example and comparative example material clotting time

[0063] Material clotting time (min)

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PUM

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Abstract

A polyurethane material containing F in side chain is prepared through alternative polymerization between the flexible chain segment consisting of polyether diol and / or polycarbonate diol and the rigid chain segment consisting of diisocyanate and chain-enlarging agent. Its advantages are high biologic stability and compatibility and high elasticity, strength and resistance to oxidizing and hydrolysis. It can be used for preparing artificial blood vessel, heart valve, etc.

Description

1. Technical Field [0001] The invention belongs to the technical field of polymer biomedical materials and their preparation, and is a side chain fluorine-containing polyurethane thermoplastic elastomer material and a preparation method thereof. 2. Background technology [0002] In the field of materials implanted in the body and in contact with blood, polyurethane has been widely used because of its high strength, high elasticity, good biocompatibility and processability, such as the insulated wire for the lead of cardiac pacemakers. , Artificial blood vessels and various medical catheters, but there are still some problems, such as thrombus formation on the surface of the polyurethane material when it comes into contact with blood, which cannot be used to make artificial small blood vessels, and polyester polyurethane is easy to hydrolyze due to the presence of ester bonds. After hydrolysis, fatty acids will be released to produce catalytic degradation [see L. Pinchuk, Journal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/32C08G18/66
Inventor 钟银屏付强谭鸿谢兴益李洁华何成生樊翠蓉
Owner SICHUAN UNIV
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