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Fe3O4 magnetofluid and its preparation

A magnetic fluid and aqueous solution technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, inorganic non-effective ingredients, etc., can solve the problems of continuous particle size change, difficulty in controlling particle size, wide particle size distribution, etc. , to achieve the effect of easy industrial application, simple method and uniform distribution

Inactive Publication Date: 2005-12-28
SHANGHAI UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Furthermore, the particle size distribution obtained by the traditional co-precipitation method is wide and it is difficult to control the size of the particles, let alone realize the continuous change of the particle size

Method used

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  • Fe3O4 magnetofluid and its preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one: the FeCl of 5L 2.35mol / L 3 The aqueous solution was mixed with 128L weight concentration of 2% polyvinyl alcohol aqueous solution, and stirred for 2 hours at a temperature of 80°C to make the Fe 3+ Coordinate with polyvinyl alcohol to obtain a polymer metal complex; then add 4L of 0.5mol / L oxalic acid aqueous solution to the above polymer metal complex at room temperature, stir evenly, and leave it open at room temperature for 3 days , the resulting Fe 3+ and Fe 2+ The aqueous solution of polyvinyl alcohol; then heat the aqueous solution to 60 ° C, and add 22L of 2mol / L NaOH aqueous solution under stirring, and continue to stir for 15 minutes, and then centrifuge to remove large particles of Fe 3 o 4 After the precipitate, black Fe was obtained 3 o 4 ferrofluid. The Fe 3 o 4 The particle size of the magnetic fluid is: 1.22nm.

Embodiment 2

[0026] Embodiment two: the processing step of the present embodiment is identical with embodiment one, and difference is that the add-on of 2% polyvinyl alcohol aqueous solution is 32L, and the black Fe that obtains 3 o 4 ferrofluid. The Fe 3 o 4 The particle size of the magnetic fluid is: 1.31nm. After sedimentation, drying and grinding of the magnetic fluid, the molar magnetic susceptibility of the obtained powder was measured with a Gouy magnetic balance to be 7.35×10 -3 / mol.

Embodiment 3

[0027] Embodiment three: the process step of this embodiment is the same as embodiment one, the difference is that the FeCl of 5L 2.35mol / L 3 The aqueous solution was mixed with 32L weight concentration of 2% polyvinyl alcohol aqueous solution, and stirred at 80°C for 1 hour to make Fe 3+ Coordination with polyvinyl alcohol; the resulting black Fe 3 o 4 ferrofluid. After the magnetic fluid is precipitated, dried, and ground, the molar magnetic susceptibility of the obtained powder is measured with a Gouy magnetic balance to be 20×10 -3 / mol.

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Abstract

The present invention relates to a kind of Fe that is used for targeting anticancer drug 3 o 4 A magnetic fluid and a preparation method thereof belong to the technical field of compounds and their preparation. The present invention adopts in-situ reduction coordination conversion method, first makes Fe 3+ It coordinates with polyvinyl alcohol to form a polymer-metal complex, and then uses a reducing agent, such as oxalic acid, to convert a part of the Fe in the coordination state 3+ reduced to Fe 2+ , and finally converted with alkali to directly obtain Fe 3 o 4 ferrofluid. Adopt the Fe prepared by the inventive method 3 o 4 Ferrofluid is based on Fe 3 o 4 It is a magnetic material, polyvinyl alcohol is used as a coating layer, and water is used as a carrier. The preparation process does not need to isolate oxygen, and the obtained Fe 3 o 4 Fe with very small particle size 3 o 4 Ferrofluid, and Fe 3 o 4 The particle size can be adjusted, and the ferrofluid can be directly obtained without adding surfactants and post-treatment procedures. In addition, the preparation method of the magnetic fluid has the characteristics of readily available and cheap raw materials, simple and easy method, and easy wide application.

Description

technical field [0001] The present invention relates to a kind of Fe that is used for targeting anticancer drug 3 o 4 A magnetic fluid and a preparation method thereof belong to the technical field of compounds and their preparation. Background technique [0002] At present, in the process of cancer treatment, in order to improve the accuracy of drug administration, improve the utilization rate and stability of drugs, and reduce the toxic and side effects of drugs on normal cells, the fourth generation of drug preparations, namely targeted drug delivery systems, has been listed as a key point in my country. Invention project. Magnetic materials play a vital role in targeted drug delivery systems. Today Fe 3 o 4 It is one of the most widely used magnetic materials, mainly through Fe 2+ and Fe 3+ Mix according to the stoichiometric ratio, and then add alkali for co-precipitation. But due to Fe 2+ It is easily oxidized in the air, so the traditional co-precipitation met...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/32
Inventor 华国飞刘引烽陈捷丁国伟华家栋
Owner SHANGHAI UNIV
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