Application of maggot extract in preparation of medicine for treating digestive diseases and medicine composition
A technology for digestive diseases and grain worms, which is applied in the direction of drug combination, digestive system, medical raw materials derived from arthropods, etc., can solve problems such as inability to treat digestive diseases, achieve clear drug effects and maintain functional integrity
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Embodiment 1
[0029] The present embodiment provides the application of the grain worm extract in the preparation of a medicine for treating digestive diseases.
[0030] Compared with the chemical drugs, antibiotics and antiviral drugs currently used in the clinical treatment of peptic ulcer, stress gastroenteritis, bacterial enteritis, viral enteritis and other digestive diseases, the grain worm extract has less toxic and side effects and is not good. Less response.
Embodiment 2
[0032] On the basis of Example 1, this example provides the application of grain worm extract for preparing medicine for treating digestive diseases, and the grain worm extract is grain worm protein extract and / or grain worm amino acid extract, wherein, The mass fraction of total protein in the grain worm protein extract is 35-90%, and the mass fraction of total amino acids in the grain worm amino acid extract is 40-95%.
[0033] The peptic disease is peptic ulcer, stress gastroenteritis, bacterial enteritis or viral enteritis.
[0034] The preparation process of grain worm protein extract is as follows:
[0035] Put sterile five-grain larvae (5 g) into a mortar, add about 3 mL of liquid nitrogen, and grind them sufficiently, and then add 5 mL of an aqueous solution containing 0.1 μg / ml aprotinin and 0.1% trifluoroacetic acid, and grind them thoroughly. The homogenate was ice-bathed in the dark for 60 min, then centrifuged (20000r / min, 4°C, 30min), the supernatant was collect...
Embodiment 3
[0039] This example is to experimentally verify the therapeutic effects of the grain worm protein extract and the grain worm amino acid extract prepared in Example 2 on peptic ulcer.
[0040] 1. Experimental method
[0041] Male Kunming mice (18-22g) were purchased from Beijing Weitong Lihua Co., Ltd. and were randomly divided into normal control group, omeprazole group (2mg / kg), and low-dose group of grain worm protein extract (5mg / kg) , Cereal worm protein extract high-dose group (10mg / kg), Cereal worm amino acid extract low-dose group (5mg / kg), Cereal worm amino acid extract high-dose group (10mg / kg), Cereal worm protein extract + Cereals worm amino acid extract (1:1, 10mg / kg), 8 animals in each group. The drug treatment group was given the corresponding drugs by gavage every day for 7 days. After the administration on the 7th day, the rats were fasted without food and water, and 1 hour after the last administration, they were given aspirin-ethanol solution (200 mg / kg of a...
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