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Nanocomposite for treating malignant tumors as well as preparation method and application thereof

A nanocomposite and malignant tumor technology, applied in the field of nanocomposites for the treatment of malignant tumors and its preparation, can solve the problems that cannot be directly applied to the diagnosis and treatment of malignant tumors, insufficient uptake of acutely toxic tumors, poor water solubility, etc., and achieve excellent Photothermal conversion ability, enhancing the effect of phototherapy and sonodynamic therapy, and the effect of easy degradation

Pending Publication Date: 2022-07-15
NINGBO FIRST HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Near-infrared fluorescent dye has good fluorescence imaging and photothermal imaging performance in the near-infrared region, and is also a high-quality sonodynamic, photothermal and photodynamic sensitizer, but it has poor water solubility, fast clearance, acute toxicity and insufficient tumor uptake and other shortcomings, so that it cannot be directly applied to the diagnosis and treatment of malignant tumors. Nanosystems can be passively targeted to tumor tissues by taking advantage of the high permeability and retention effect of solid tumor tissues, but less than 1% of the total amount actually reaches the tumor site. %

Method used

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  • Nanocomposite for treating malignant tumors as well as preparation method and application thereof
  • Nanocomposite for treating malignant tumors as well as preparation method and application thereof
  • Nanocomposite for treating malignant tumors as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] S1. Disperse 1 g of solid sodium hydroxide in 40 mL of N-methylpyrrolidone, and perform ultrasonic treatment to obtain a saturated sodium hydroxide N-methylpyrrolidone solution. Then 20mg black phosphorus powder was dispersed in the above solution, ultrasonically pulverized in ice water for 8h (3s cycle, 3s intermittent, 400W), then ultrasonically peeled for 10h, and a cooling circulation device was added to maintain the surrounding water temperature below 20 °C. The obtained brown-black suspension was centrifuged at 6000 r / min for 10 min to remove unflaked black phosphorus particles, the supernatant was collected, and then the precipitate was collected by centrifugation at 12000 r / min for 20 min. Washed twice with alcohol and deionized water, and then freeze-dried to obtain black phosphorus nanosheets.

[0038] S2. Preparation of cationic polymer-modified near-infrared dye NH 2 -PEG2000-IR780 and cationic polymer modified tumor targeting molecule NH 2 -PEG-RGD;

[0...

Embodiment 2-10

[0044] The only difference from Example 1 is that the cationic polymer and the near-infrared dye are shown in Table 1.

[0045] Table 1: Example 2-10 cationic polymer, tumor targeting molecule, near-infrared dye raw material selection

[0046] Example Cationic polymer tumor targeting molecule near-infrared dyes Example 2 NH 2 -PEG

[0047] The tumor targeting molecule RGD is a polypeptide whose amino acid sequence arginine, glycine and aspartic acid are arranged in order.

Embodiment 11-20

[0049] The only difference from Example 1 is that the cationic polymers, tumor targeting molecules, and near-infrared dyes are shown in Table 2.

[0050] Table 2: Examples 11-20 cationic polymers, tumor targeting molecules, and selection of raw materials for near-infrared dyes

[0051]

[0052]

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Abstract

The invention belongs to the technical field of tumor resistance, and particularly relates to a nano compound for treating malignant tumors as well as a preparation method and application of the nano compound. The nano-composite comprises black phosphorus nanosheets, tumor targeting molecules and near-infrared dye, and has the characteristics of large specific surface area, good biocompatibility, easiness in degradation, excellent active oxygen generation capability, excellent photo-thermal conversion capability and the like.

Description

technical field [0001] The invention belongs to the technical field of anti-tumor, and in particular relates to a nano-composite for treating malignant tumor and a preparation method and application thereof. Background technique [0002] Malignant tumors seriously threaten human life and health, and bring serious mental and economic burdens to families and society. Phototherapy and sonodynamic therapy, as an alternative and supplement to traditional treatment techniques, have become a research hotspot in medicine and materials science due to their unique advantages such as high efficiency, minimally invasive, specific tumor treatment, small side effects, and low systemic toxicity. [0003] Phototherapy includes photothermal therapy and photodynamic therapy. Photothermal therapy is a type of thermal therapy that converts light energy into heat energy through photothermal agents to thermally ablate target cells. Photodynamic therapy relies on photosensitizers to generate reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/54A61K47/58A61K47/60A61K47/61A61K47/64A61K47/68A61K49/22A61K49/00A61K9/19A61P35/00
CPCA61K41/0052A61K49/0069A61K49/222A61K47/60A61K47/58A61K47/61A61K49/0054A61K49/0002A61K47/545A61K47/64A61K47/68A61K41/0033A61P35/00A61K9/19A61K2300/00
Inventor 朱雪丽李娟吴爱国张盛敏许幼峰
Owner NINGBO FIRST HOSPITAL
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