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Sugar-coated tablet and preparation method thereof

A sugar-coated tablet and sugar-coated technology, applied in the field of rhinitis drugs, can solve problems such as bad smell, poor patient experience, cumbersome procedures, etc., and achieve the effects of improved storage validity period, excellent disintegration, and convenient use

Pending Publication Date: 2022-07-05
广东省惠州市中药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The applicant disclosed a nasal comfort tablet in the invention patent with the application number CN202010124485.0. The nasal comfort tablet includes the following traditional Chinese medicine components in parts by mass: 300-400 parts of cocklebur, 120-160 parts of wild chrysanthemum, goose 200-220 parts of non-grass, 100-120 parts of Angelica dahurica, 100-120 parts of Fangfeng, 200-220 parts of Eclipta, 130-160 parts of white peony, 60-80 parts of Dannanxing, 65-85 parts of licorice, 200 parts of Tribulus terrestris ~220 parts and 0.1~0.5 parts of chlorpheniramine. The nasal comfort tablet is obtained by performing granulation operation and tabletting operation on the dry paste powder. When using the nasal comfort tablet, the nasal comfort tablet and water need to be put into the distilled Distillation operation is carried out in the device to obtain liquid medicine vapor, and the liquid medicine vapor enters the nostril through the drainage column, and the procedure is more cumbersome in use
If the Nasal Comfort Tablet is taken orally, due to the bitter taste and bad smell of traditional Chinese medicine in the Nasal Comfort Tablet, the patient’s oral experience is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo.

[0035] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 30 parts of cocklebur, 10 parts of wild chrysanthemum, 20 parts of goose not eating grass, and seedless prickly pear. 10 parts, Ashitaba 10 parts, Eclipta chinensis 20 parts, Paeonia lactiflora 10 parts, Microcrystalline Cellulose 6 parts, Magnesium stearate 2 parts, Sodium citrate 1 part and Chlorpheniramine 0.05 parts.

[0036] Wherein, the sugar coating is composed of the following components by weight: 5 parts of polyethylene glycol acrylate, 5 parts of triethylene glycol diacrylate, 5 parts of isomalt oligosaccharides, 2 parts of lactose, 0.2 parts of stevia, erythrose 0.5 part of alcohol, 0.5 part of mannitol, and 5 parts of xylitol.

...

Embodiment 2

[0045] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo. The preparation method of the sugar-coated tablet is the same as the preparation method of the sugar-coated tablet provided in Example 1.

[0046] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 40 parts of Xanthium japonica, 15 parts of wild chrysanthemum, 22 parts of goose not eating grass, and seedless prickly pear. 15 parts, 15 parts of Ashitaba, 22 parts of Echinacea, 15 parts of white peony, 8 parts of microcrystalline cellulose, 2 to 3 parts of magnesium stearate, 5 parts of sodium citrate and 0.1 part of chlorpheniramine.

[0047] Wherein, the sugar coating is composed of the following components by weight: 10 parts of polyethylene glycol acrylate, 10 parts of triethylene glycol diacrylate, ...

Embodiment 3

[0049] This embodiment provides a sugar-coated tablet, which includes a tablet embryo and a sugar coating that wraps the tablet embryo. The preparation method of the sugar-coated tablet is the same as the preparation method of the sugar-coated tablet provided in Example 1.

[0050] Wherein, the tablet embryo is obtained by performing the shaping and tableting operation of the medicinal granules, and the medicinal granules are composed of the following components by weight: 35 parts of cocklebur, 12 parts of wild chrysanthemum, 21 parts of goose not eating grass, and seedless prickly pear. 14 parts, 12 parts of Ashitaba, 21 parts of Echinacea, 12 parts of white peony, 7 parts of microcrystalline cellulose, 2.5 parts of magnesium stearate, 3 parts of sodium citrate and 0.08 parts of chlorpheniramine.

[0051] Wherein, the sugar coating is composed of the following components by weight: 7 parts of polyethylene glycol acrylate, 8 parts of triethylene glycol diacrylate, 10 parts of...

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PUM

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Abstract

The invention relates to a sugar-coated tablet. The sugar-coated tablet comprises a tablet blank and a sugar coating wrapping the tablet blank. The tablet blank is obtained by carrying out shaping and tabletting operation on medicine granules, and the medicine granules are prepared from the following components in parts by weight: 30 to 40 parts of fructus xanthii, 10 to 15 parts of flos chrysanthemi indici, 20 to 22 parts of herba centipedae, 10 to 15 parts of seedless roxburgh rose, 10 to 15 parts of angelica keiskei, 20 to 22 parts of herba ecliptae, 10 to 15 parts of radix paeoniae alba, 6 to 8 parts of microcrystalline cellulose, 2 to 3 parts of magnesium stearate, 1 to 5 parts of sodium citrate and 0.05 to 0.1 part of chlortrimeton. The sugar coating is prepared from the following components in parts by weight: 5 to 10 parts of polyethylene glycol acrylate, 5 to 10 parts of triethylene glycol diacrylate, 5 to 15 parts of isomaltooligosacharide, 2 to 5 parts of lactose, 0.2 to 3 parts of stevioside, 0.5 to 1 part of erythritol, 0.5 to 1 part of mannitol and 5 to 10 parts of xylitol. The invention also relates to a preparation method of the sugar-coated tablet.

Description

technical field [0001] The invention relates to the field of rhinitis medicine, in particular to a sugar-coated tablet for treating chronic rhinitis and a preparation method thereof. Background technique [0002] Nasal Comfort Tablet has the functions of clearing heat, reducing inflammation and clearing orifices, and is used to treat sneezing, runny nose, nasal congestion, headache, allergic rhinitis and chronic sinusitis caused by chronic rhinitis. At present, the active ingredients in nasal comfort tablets can be mixed with conventional adjuvants and / or excipients to prepare various pharmaceutical dosage forms (such as capsules, tablets, granules, sugar-coated pills, solutions, etc.). Among them, commonly used excipients include: fillers and compatibilizers (such as starch, microcrystalline fibers, etc.), binders (such as carboxymethyl cellulose, polyvinylpyrrolidone, etc.), humectants (such as glycerol), disintegrating agents Agents (such as calcium carbonate, etc.), abs...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61K9/20A61K47/38A61K47/12A61K9/36A61K47/26A61K47/14A61P11/02A61P37/08A61K31/4402
CPCA61K36/28A61K36/287A61K36/738A61K36/232A61K36/71A61K36/65A61K31/4402A61K9/2054A61K9/2013A61K9/2893A61K9/2826A61K9/0056A61K9/2853A61K9/282A61P11/02A61P37/08A61K2236/333A61K2300/00
Inventor 李玉英李六平黄向群
Owner 广东省惠州市中药厂有限公司
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