Temperature-sensitive debonding wet tissue adhesion hydrogel and preparation method thereof

Abstract

The invention discloses a temperature-sensitive debonding wet tissue adhesion hydrogel and a preparation method thereof, and the preparation method comprises the following steps: S1, dissolving N-isopropylacrylamide, acrylamide, amino-containing biomacromolecules and calcium chloride in water to obtain a solution a; s2, urushiol, a cross-linking agent and a photoinitiator are added into the solution a and stirred to be dissolved, and a solution b is obtained; s3, the solution b is poured into a mold and cured under ultraviolet irradiation, and the temperature-sensitive debonding wet tissue adhesion hydrogel is obtained. The preparation method has the advantages that the preparation process of the wet tissue adhesion hydrogel is simple, and the forming time is short; the hydrogel can be quickly adhered to wet biological tissues; the hydrogel has high adhesion performance with biological tissues; the hydrogel can realize thermo-sensitive on-demand stripping only by normal-temperature water treatment; when the hydrogel is debonded, the operation is simple, and the debonding process is harmless to organisms; the wet tissue adhesion hydrogel can be used for closing wounds, blocking and stopping bleeding, and treating and curing animals in water.

Description

technical field [0001] The invention belongs to the technical field of preparation of tissue adhesive, in particular to a temperature-sensitive debonding wet tissue adhesion hydrogel and a preparation method thereof. Background technique [0002] In daily life, people experience various traumas, which are mainly skin damage, visceral rupture and so on. The most commonly used methods for treating wounds are suturing and stapling. Using these mechanical methods to treat wounds not only brings additional pain to the patient, but also is not easy to disassemble later. To reduce pain from mechanical methods, tissue glue is a good choice. Cyanoacrylate is a commonly used tissue adhesive that can form a solid-phase interface at tissue wounds to bond damaged tissue. However, its poor adhesion on wet tissues and the release of biotoxic cyanoacetates during degradation limit its use. With the increasing pursuit of a better life, modern medicine requires that the pain of the patient...

AI Technical Summary

Problems solved by technology

Mussel-like adhesive hydrogel can exhibit excellent wet tissue adhesion, but it is difficult to peel off after use, which brings difficulties to practical application

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