Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of ginsenoside Re in preparation of antidepressant drug

A ginsenoside, antidepressant technology, applied in the field of medicine, achieves the effect of obvious decline in learning and memory ability and alleviation of the decline in learning and memory ability

Pending Publication Date: 2022-05-24
JILIN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no studies have reported the antidepressant effect and mechanism of ginsenoside Re on reserpine-induced depression models.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of ginsenoside Re in preparation of antidepressant drug
  • Application of ginsenoside Re in preparation of antidepressant drug
  • Application of ginsenoside Re in preparation of antidepressant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. The effect of ginsenoside Re administration for 7 days on the depression-like behavior of reserpine-induced depression model in mice.

[0027] Main drugs and reagents: ginsenoside Re (Ginsenoside Re, GS-Re), fluoxetine hydrochloride (Fluoxetine Hydrochloride, sigma), reserpine (Reserpine crystallized, sigma).

[0028] Experimental animals: Male SPF grade ICR mice, weighing 21-23 g, were housed in a single cage in the barrier environment of the Animal Experiment Center, School of Basic Medicine, Jilin University, maintaining a 12-h circadian rhythm, the indoor temperature was controlled at 22 ± 1 °C, and adequate water and feed were given. , free water and food intake. All animal experiments were carried out in accordance with the relevant regulations of the Animal Ethics Committee of Jilin University.

[0029] Main experimental instruments: mouse open field behavior tester (self-made, diameter 48.8cm, diameter 16cm, bottom 19 equal parts), mouse forced swimm...

Embodiment 2

[0054] Example 2. The mechanism of the effect of repeated administration of ginsenoside Re for 7 days on the depression-like behavior of reserpine-induced depression model mice.

[0055] Main medicines and reagents: Ginsenoside Re (Ginsenoside Re, GS-Re), Fluoxetine Hydrochloride (sigma), Reserpine crystallized (sigma), anti-TrkB antibody was purchased from Cell Signaling Technology, USA, anti- GAPDH antibody and HRP antibody were purchased from sigma.

[0056] Experimental animals: Male SPF grade ICR mice, weighing 21-23 g, were housed in a single cage in the barrier environment of the Animal Experiment Center, School of Basic Medicine, Jilin University, maintaining a 12-h circadian rhythm, the indoor temperature was controlled at 22 ± 1 °C, and adequate water and feed were given. , free water and food intake. All animal experiments were carried out in accordance with the relevant regulations of the Animal Ethics Committee of Jilin University.

[0057] Main experimental ins...

Embodiment 3

[0071] Example 3. Effects of ginsenoside Re administration for 14 days on depression behavior, ptosis and body temperature in a reserpine-induced depression model in mice.

[0072] Main drugs and reagents: Ginsenoside Re (GS-Re), Fluoxetine Hydrochloride (sigma), Reserpine crystallized (sigma)

[0073] Experimental animals: Male SPF grade ICR mice, weighing 21-23 g, were housed in a single cage in the barrier environment of the Animal Experiment Center, School of Basic Medicine, Jilin University, maintaining a 12-h circadian rhythm, the indoor temperature was controlled at 22 ± 1 °C, and adequate water and feed were given. , free water and food intake. All animal experiments were carried out in accordance with the relevant regulations of the Animal Ethics Committee of Jilin University.

[0074] Main experimental instruments: The main experimental instruments are the same as above

[0075] Grouping and administration: ICR male mice were randomly divided into 5 groups (10 mice...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of ginsenoside Re in preparation of antidepressant drugs, namely application of ginsenoside Re in treatment of depression, and the effect of ginsenoside Re on reserpine-induced depression-like behaviors is explained from the two aspects of administration dosage and administration time of ginsenoside Re. Repeated administration of ginsenoside Re for 7 days or 14 days can reduce immobility time prolonged by reserpine in forced swimming and tail suspension experiments, is caused by activation of a TrkB signal channel, and can improve learning and memory ability of mice. The mechanism of ginsenoside Re for generating the anti-depression effect is clarified for the first time, a basis is provided for ginsenoside Re as an anti-depression drug, and meanwhile, the ginsenoside Re has important economic and social values for development of the anti-depression drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of ginsenoside Re in the preparation of antidepressant drugs. Background technique [0002] Depression is a common affective mental disorder characterized by depression caused by a variety of reasons. Obstacles and pain, such as low mood, depression, insomnia, self-blame, sluggish thinking, fatigue, living alone, social avoidance, memory loss, etc. For example, according to the World Health Organization data in recent years, the number of people suffering from depression is second only to diseases such as heart disease and AIDS. By 2030, it will become one of the diseases with the largest burden in the world. [0003] At present, most of the drug treatments are based on chemically synthesized western medicines, such as serotonin reuptake inhibitors and dual serotonin and norepinephrine reuptake inhibitors. The main effect of these drugs is closely related to in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K45/06A61P25/24A61K36/258
CPCA61K31/704A61K45/06A61P25/24A61K36/258A61K2300/00
Inventor 李炳锦程子倩赵芳一董萌萌赵丽红
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com