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Preparation method of degradable orthopedic implant material capable of dual self-healing and controllable drug release

An implanted material and self-healing technology, which is applied in drug delivery, pharmaceutical formulation, medical science, etc., can solve the problem that the surface coating structure and performance of magnesium alloys are difficult to recover independently, and it is difficult to detect changes in micro/nano cracks on the coating surface , Accelerate the corrosion and degradation of magnesium alloys, and achieve the effects of adjustable drug release kinetics, good degradability, and high drug loading

Active Publication Date: 2022-05-17
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual service process, once the polymer corrosion-resistant coating is subjected to physical damage such as scratching and extrusion, the micro-cracks generated will expose the underlying magnesium alloy matrix, resulting in the loss of the protective effect of the coating, thereby accelerating the corrosion degradation of the magnesium alloy.
At the same time, it is difficult to detect the changes of micro / nano cracks on the surface of the coating in real time through technical means, and the original structure and properties of the magnesium alloy surface coating are difficult to fully recover autonomously.

Method used

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  • Preparation method of degradable orthopedic implant material capable of dual self-healing and controllable drug release
  • Preparation method of degradable orthopedic implant material capable of dual self-healing and controllable drug release
  • Preparation method of degradable orthopedic implant material capable of dual self-healing and controllable drug release

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Experimental program
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Effect test

Embodiment 1

[0034] The specific preparation method of the degradable orthopedic implant material capable of double self-healing and controlled drug release includes the following steps:

[0035] 1) Select a medical magnesium alloy, extrude it into a magnesium alloy plate, and process it into a specific shape and structure;

[0036] 2) Magnesium substrate pretreatment: the surface of the magnesium alloy material is polished with ultra-fine sandpaper until no scratches are visible to the naked eye, washed with water and dried. Then, immerse in a sodium hydroxide solution with a concentration of 5 mol / L to carry out alkalization pretreatment. Clean the solution and impurities on the surface and dry it for later use;

[0037] 3) Preparation of the precursor coating: prepare a polyethyleneimine solution with a concentration of 10 g / L. The pretreated magnesium matrix is ​​placed on the sample holder of the glue homogenizer, and the vacuum pump and the glue homogenizer are turned on. Spray 0....

Embodiment 2

[0046] The specific preparation method of the degradable orthopedic implant material capable of double self-healing and controlled drug release includes the following steps:

[0047] 1) Select a medical magnesium alloy, extrude it into a magnesium alloy plate, and process it into a specific shape and structure;

[0048] 2) Magnesium substrate pretreatment: the surface of the magnesium alloy material is polished with ultra-fine sandpaper until no scratches are visible to the naked eye, washed with water and dried. Then, it is immersed in a sodium hydroxide solution with a concentration of 2 mol / L to carry out alkalization pretreatment. Clean the solution and impurities on the surface and dry it for later use;

[0049] 3) Preparation of the precursor coating: prepare a polyethyleneimine solution with a concentration of 25 g / L. The pretreated magnesium matrix is ​​placed on the sample holder of the glue homogenizer, and the vacuum pump and the glue homogenizer are turned on. S...

Embodiment 3

[0058] The specific preparation method of the degradable orthopedic implant material capable of double self-healing and controlled drug release includes the following steps:

[0059] 1) Select a medical magnesium alloy, extrude it into a magnesium alloy plate, and process it into a specific shape and structure;

[0060] 2) Magnesium substrate pretreatment: the surface of the magnesium alloy material is polished with ultra-fine sandpaper until no scratches are visible to the naked eye, washed with water and dried. Then, it is immersed in a sodium hydroxide solution with a concentration of 4 mol / L to carry out alkalization pretreatment. Clean the solution and impurities on the surface and dry it for later use;

[0061] 3) Precursor coating preparation: a polyethyleneimine solution with a concentration of 5 g / L was prepared. The pretreated magnesium matrix is ​​placed on the sample holder of the glue homogenizer, and the vacuum pump and the glue homogenizer are turned on. Spra...

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Abstract

The invention discloses a preparation method of a degradable orthopedic implant material capable of dual self-healing and controllable drug release. According to the material, hyaluronic acid and polyethyleneimine intrinsic self-healing polymer coatings are assembled on the surface of magnesium alloy layer by layer, mesoporous silica nanoparticles serve as a carrier nano platform of the coating composite stimulation-responsive drug-loaded nanocapsule, a small molecule corrosion inhibitor paeonol can be embedded, and the outermost layer is coated with polydopamine macromolecules. The orthopedic implant material has good functions of self-healing, corrosion protection, drug controlled release and the like at the same time. A coating on the surface of the magnesium alloy implant material is uniform, compact and high in binding force. The drug-loading nanocapsule is high in drug loading capacity, and drug release kinetics can be regulated and controlled.

Description

technical field [0001] The invention belongs to medical materials and a preparation method, in particular to a preparation method of a degradable orthopedic implant material capable of double self-healing and controllable drug release. Background technique [0002] At present, the metal-based bioimplantable materials widely used in clinical medicine are mainly titanium alloy, cobalt-chromium alloy and stainless steel. These materials generally have a high elastic modulus, have a stress shielding effect, and are not degradable in the body, which increases the risk of secondary surgery. As a new generation of bioimplantable materials, magnesium and its alloys have good mechanical properties, processability, degradability and biocompatibility, which can avoid secondary surgery. Therefore, degradable magnesium alloys can be used as bone implant materials. [0003] Magnesium alloys are chemically active, and at the initial stage of implantation, too fast a corrosion degradation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/34A61L27/50A61L27/54A61L27/58
CPCA61L27/047A61L27/34A61L27/54A61L27/50A61L27/58A61L2300/216A61L2300/412A61L2300/624A61L2400/18A61L2420/02A61L2420/04A61L2420/08A61L2430/02C08L5/08C08L79/02C08L79/04
Inventor 储成林赵延斌龙子螣吴思琦陈曦
Owner SOUTHEAST UNIV
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