Polyurethane material with composite moisturizing coating and application of polyurethane material in field of interventional therapy

Abstract

The invention relates to a polyurethane material with a composite moisturizing coating and application of the polyurethane material in the field of interventional therapy. The invention provides a method for constructing a stable composite moisturizing coating on the surface of polyurethane, the composite moisturizing coating comprises a polydopamine-natural polymer layer and a zwitterionic lubricating layer, and the preparation method comprises the following steps: (1) carrying out low-temperature plasma treatment on polyurethane for surface activation; (2) dissolving dopamine and a natural polymer in a tris (hydroxymethyl) aminomethane buffer solution to serve as a modified solution, and then immersing the activated polyurethane into the modified solution to construct a polydopamine-natural polymer layer; and (3) methacryloylethyl sulfobetaine is grafted to the pamine-natural polymer layer by using an oxidation catalyst to construct a dense and stable composite moisturizing coating, and deionized water is used for ultrasonic cleaning. The surface wettability of the modified polyurethane is remarkably improved, the friction coefficient is effectively reduced, the leaching stability is good, and the service life is long. The method has great application potential in the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of interventional medical devices, and in particular relates to a polyurethane material with a composite water-wetting coating, a preparation method of the material and its application in the field of interventional therapy. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, interventional therapy has developed rapidly and is currently the third fastest-growing therapeutic discipline after internal medicine and surgery, which makes up for the shortage of internal and surgical techniques. Interventional therapy is a new type of high-tech minimally invasive treatment technology, which has the ...

AI Technical Summary

Problems solved by technology

In vascular interventional surgery, there are problems such as difficulty in catheter insertion and high resistance. This is due to the poor wettability and poor friction performance of the polyurethane surface. Therefore, it is urgent to explore the construction of a polyurethane surface with high wettability and low friction. To expand the application field of vascular interventional therapy and improve the safety of interventional surgery

[0004] Constructing a hydrophilic coating on the surface of the interventional catheter is an effective strategy to improve wettability and reduce the coefficient of friction. The existing improvement methods are as follows: (1) Construct a layer of hydrogel coating on the surface of the catheter, but the hydrogel coating absorbs water The expansion is not suitable for thin catheters, and the strength is weak and easy to fall off; (2) A layer of hydrophilic polymer coating is constructed on the surface of the catheter by physical and chemical adsorption, but the coating is unstable and has poor bearing capacity; (3) The surface is grafted with polymer molecular brushes, but the lubricating effect depends on the graft density and the length of the polymer molecular brushes, and the lubricating effect of the molecular brushes at the macro level is not ideal. The current research direction is to construct a composite lubricating coating, but it is still not satisfactory Low friction, high load, high stability requirements

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