Naringin nano inhalation powder inhalation taking polylysine as carrier as well as preparation method and application of naringin nano inhalation powder inhalation

Abstract

The invention relates to the field of nano-drug inhalation preparations, in particular to preparation of naringin nano-inhalation powder inhalation taking polylysine PL as a carrier and research on the treatment effect of the naringin nano-inhalation powder inhalation on cough after infection. The preparation method comprises the following steps: firstly, preparing a naringin nano suspension by adopting a medium grinding method based on a Top-down principle, and then further drying and curing by adopting a spray drying method to obtain the naringin nano inhalation powder aerosol. The naringin nano inhalation powder inhalation disclosed by the invention is simple in preparation process, high in drug loading capacity and good in in-vivo release effect; in-vivo pharmacodynamic experiment results show that the prepared naringin nano inhalation dry powder can significantly improve the cough relieving, anti-inflammatory and anti-oxidation curative effects of the medicine, and the naringin nano inhalation dry powder enables the medicine and a carrier to be absolutely safe due to the fact that no organic reagent is added in the whole preparation process, and has great market application and popularization prospects.

Description

Technical field [0001] The present invention relates to the field of nano-drug suction preparations, and more particularly to the preparation of pombletyin nano inhalation of pompelopolis nano induced by polylysine P1 and its study on cough in infection. Background technique [0002] Studies have shown that pomodinis has bioactivity such as cough, anti-inflammatory, anti-oxidation, but pomeline is low due to low solubility, slow dissolution, resulting in poor oral bioavailability, and the pharmacodynamic effect is not fully played in the body, thus limiting its clinic application. At present, the method of improving the solubility of the difficult soluble drug has a salt, a co-solvent, micronized, and has a solid dispersion and prodrug, but each method has certain limitations. [0003] PL is rich in cation, can be prepared into a nano system by static power, and has good penetration for the biofilm. Based on this feature of polylysine can be used for some drug carriers, therefore...

AI Technical Summary

Problems solved by technology

Due to the inconsistency between start-up and inhalation of aerosol, the rapid evaporation of the propellant during start-up produces a cooling effect, and the impact of propellant Freon on environmental protection, etc., its application is subject to certain restrictions, especially for active protein and polypeptide drugs. The solubility in the drug is poor, and the stability and dosage are difficult to meet the requirements; while the atomized drug relies on relatively bulky drug delivery devices such as nebulizers, and the inhalation lasts for a long time, which is not easy to popularize and is not suitable for outpatient use.

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