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Modified blood purification membrane and preparation method thereof

A blood purification and modification technology, applied in the field of medicine, can solve the problems of reducing anti-inflammatory, not inventing anti-inflammatory modification of blood purification membrane, reducing the number of lymphocytes, etc., to reduce the formation of thrombus, increase hydrophilic performance, Safe and simple preparation method

Active Publication Date: 2022-03-15
XIANGYA HOSPITAL CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, most of the blood purification membrane modification is aimed at anticoagulation and antithrombotic, and there are few researches and developments on blood purification membranes modified by inhibiting lymphocytes for anti-inflammation. A dialysis membrane that can effectively inhibit the inflammatory response at the membrane-blood interface is imminent
[0003] Fingolimod (FTY720) is a new type of immunosuppressant for sphingosine 1-phosphate receptors extracted from Cordyceps sinensis [4], which can induce lymphocyte apoptosis, inhibit T lymphocyte activity, and reduce the number of lymphocytes in the blood. Inhibit the infiltration of inflammatory cells, reduce the anti-inflammatory effects of inflammatory factors TNF-α and IL-6 secretion levels [5], the US Food and Drug Administration (FDA) announced in September 2010 that it has been approved for marketing, but there is no invention Use it to improve anti-inflammatory modification of blood purification membranes

Method used

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  • Modified blood purification membrane and preparation method thereof
  • Modified blood purification membrane and preparation method thereof
  • Modified blood purification membrane and preparation method thereof

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preparation example Construction

[0042] Specifically, on the one hand, an embodiment of the present invention provides a method for preparing a modified blood purification membrane, including the following steps:

[0043] (1) Preparation of chloromethylated polymer: Dissolve chloromethyl methyl ether, anhydrous zinc chloride and polymer in chloroform at a molar ratio of 10-15:2-5:1 and seal with nitrogen, then place Stirring and reacting in a water bath at 50-60°C for 2-8 hours to obtain the first reactant; filtering the first reactant, taking the filter residue, washing and drying to obtain the chloromethylated polymer;

[0044] (2) Preparation of fingolimod modified polymer: dissolving fingolimod, triethylamine and the chloromethylated polymer of step (1) in N , in N-dimethylformamide, and then placed in a water bath at 50-60°C for 10-16 hours to obtain the second reactant; filter the second reactant, take the filter residue and wash it and dry it to obtain fingomole German modified polymer;

[0045](3) P...

Embodiment 1

[0066] A preparation method of a modified blood purification membrane, comprising the steps of:

[0067] (1) Preparation of chloromethylated polysulfone: chloromethyl methyl ether, anhydrous ZnCl 2 And polysulfone was dissolved in 20mL of chloroform with a molar ratio of 10:2:1 (the concentration of polysulfone was controlled within the range of 3%) and nitrogen blanketed, and then placed in a water bath at 50° C. for 2 h to obtain the first reactant; The first reactant was filtered, and the filter residue was taken, washed 3 times with absolute ethanol, and then dried in a vacuum oven at 60°C for 24 hours to obtain chloromethylated polysulfone;

[0068] (2) Preparation of fingolimod-modified polysulfone: dissolve fingolimod, triethylamine, and chloromethylated polysulfone in step (1) at a molar ratio of 8:1.5:1 in 15 mL of N, In N-dimethylformamide (the concentration of chloromethylated polysulfone is controlled in the range of 2%), and then placed in a 50°C water bath for 1...

Embodiment 2

[0072] A preparation method of a modified blood purification membrane, comprising the steps of:

[0073] (1) Preparation of chloromethylated polysulfone: chloromethyl methyl ether, anhydrous ZnCl 2 And polysulfone was dissolved in 20mL chloroform with a molar ratio of 15:5:1 (the concentration of polysulfone was controlled in the range of 6%) and nitrogen blanketed, and then placed in a water bath at 60° C. for 8 h to obtain the first reactant; The first reactant was filtered, and the filter residue was taken, washed 3 times with absolute ethanol, and then dried in a vacuum oven at 60°C for 24 hours to obtain chloromethylated polysulfone;

[0074] (2) Preparation of fingolimod-modified polysulfone: dissolve fingolimod, triethylamine, and chloromethylated polysulfone in step (1) at a molar ratio of 20:3:1 in 15 mL of N, N-dimethylformamide (the concentration of chloromethylated polysulfone is controlled in the range of 8%), and then placed in a 60°C water bath for 16h to obtai...

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Abstract

The invention discloses a modified blood purification membrane and a preparation method thereof, and belongs to the technical field of medicine and pharmacology. The preparation method comprises the following steps: (1) preparing a chloromethylated polymer; (2) preparing a fingolimod modified polymer; and (3) preparation of the fingolimod modified polymer film. The invention also provides the modified blood purification membrane obtained by the preparation method. The fingolimod is grafted to polysulfone or polyethersulfone, so that the prepared modified blood purification membrane has better blood compatibility, can directly inhibit lymphocyte activity to achieve an anti-inflammatory effect, and can improve hydrophilic performance through hydroxyl of the fingolimod while effectively resisting inflammation, thereby reducing formation of thrombus and improving the blood purification effect. The medicine is suitable for treatment of patients with various severe infections and multi-organ function failure. The preparation method disclosed by the invention is safe and simple, can be realized through a two-step synthesis method, is relatively short in preparation period and can be suitable for industrial batch production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a modified blood purification membrane and a preparation method thereof. Background technique [0002] Inflammatory cytokine storm is an important cause of acute liver and kidney failure, acute lung injury, severe pancreatitis, sepsis and other diseases. In this excessive immune response, cytokines and leukocytes, through a specific positive feedback regulation mechanism, make the levels of various inflammatory factors in tissues and organs increase uncontrollably, eventually leading to multiple organ failure and even death. Blood purification therapy has played an important anti-inflammatory role in the above-mentioned inflammatory factor storm-related diseases. However, the currently used blood purification membranes have average hemocompatibility. In addition to being prone to thrombus formation and requiring routine anticoagulation, there is also the risk of agg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/02C08G75/20C08G75/23
CPCB01D67/0013B01D67/0016B01D67/0011B01D69/02C08G75/20C08G75/23A61M1/1621A61M1/3621A61M1/34B01D2323/02B01D2325/36A61M2202/0413A61M2202/0021
Inventor 府晓汤赐
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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