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Moisturizing NMN hydrophilic gel and preparation method thereof

A technology of hydrophilic gel and humectant, applied in pharmaceutical formulations, aerosol delivery, organic active ingredients, etc., can solve the problems of NMN being unstable in acid, unable to reach the skin, low bioavailability, etc., to achieve compliance good, improve bioavailability, protect cells

Pending Publication Date: 2022-03-04
药酚享科技北京有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation of NMN is mainly capsules, and oral administration of NMN capsules has the following problems: NMN is unstable when encountering acid, and is prone to degradation and damage
When oral NMN passes through the stomach, it is affected by gastric acid and loses its activity, resulting in low bioavailability
After taking NMN orally, the reaching site is also limited and cannot reach the skin

Method used

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  • Moisturizing NMN hydrophilic gel and preparation method thereof
  • Moisturizing NMN hydrophilic gel and preparation method thereof
  • Moisturizing NMN hydrophilic gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, preparation high moisture retention NMN hydrophilic gel

[0042] The component content of the NMN hydrophilic gel agent of table 1 embodiment 1

[0043] Element Proportion β-nicotinamide mononucleotide (NMN) 5％ Poloxamer 188 20％ Poloxamer 407 25％ betaine 5％ Sodium hyaluronate 1.5％ Triethanolamine 3％ ascorbic acid 0.1％ Methylparaben 0.5％ purified water 40.4％

[0044] Prepare as follows:

[0045] 1) Disperse the gel matrix poloxamer 188 and poloxamer 407 in 60% purified water, let stand at 3-5° C., slowly swell for 24 hours to obtain a uniform gel matrix solution, and obtain the first solution.

[0046] 2) In a stirring state, add β-nicotinamide mononucleotide (NMN), betaine, ascorbic acid, and methylparaben into 30% purified water, and stir evenly.

[0047] 3) In the state of stirring, add sodium hyaluronate and the remaining purified water, and stir evenly to obtain the second solution....

Embodiment 2

[0050] Embodiment 2, preparation high moisture retention NMN hydrophilic gel

[0051] The component content of the NMN hydrophilic gel agent of table 2 embodiment 2

[0052] Element Proportion β-nicotinamide mononucleotide (NMN) 5％ sodium alginate 3％ betaine 6％ Propylene Glycol 5％ Sodium hyaluronate 0.5％ Triethanolamine 2％ Leucine 1％ Ethylparaben 0.5％ purified water 77％

[0053] Prepare as follows:

[0054] 1) Disperse the gel matrix sodium alginate in 70% purified water, let it stand at room temperature, slowly swell for 24 hours to obtain a uniform gel matrix solution, and obtain the first solution.

[0055] 2) In a stirring state, add β-nicotinamide mononucleotide (NMN), betaine, propylene glycol, sodium hyaluronate, leucine, and ethylparaben into 20% purified water, and stir evenly.

[0056] 3) In the stirring state, add triethanolamine, then add the remaining purified water, and mix evenly to obtain th...

Embodiment 3

[0059] Embodiment 3, preparation high moisture retention NMN hydrophilic gel

[0060] The component content of the NMN hydrophilic gel agent of table 3 embodiment 3

[0061]

[0062]

[0063] Prepare as follows:

[0064] 1) Disperse the gel matrix sodium alginate in 60% purified water, let it stand at room temperature, and slowly swell for 24 hours to obtain a uniform gel matrix solution and obtain the first solution.

[0065] 2) In a stirring state, add β-nicotinamide mononucleotide (NMN), betaine, propylene glycol, PEG-400, ascorbic acid, and sodium benzoate into 20% purified water, and stir evenly.

[0066] 3) In the stirring state, add triethanolamine, then add the remaining purified water, and mix evenly to obtain the second solution.

[0067] 4) Add the second solution into the first solution under stirring, add triethanolamine to adjust the pH value, control the pH to 7.0, and stir evenly.

[0068] 5) A small amount of air bubbles are removed by vacuum to obtain ...

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Abstract

The invention discloses a moisturizing NMN hydrophilic gel and a preparation method of the moisturizing NMN hydrophilic gel. The NMN hydrophilic gel is prepared from the following components in percentage by mass: 1-10% of beta-nicotinamide mononucleotide and the balance of water. 2-40% of a gel matrix; 1-13% of a humectant; 0.5%-10% of a penetration enhancer; 0.5-3% of a pH regulator; 0.1-1% of a preservative; 0.1%-1% of a supplement; and the balance of water. The gel matrix is sodium alginate or poloxamer; and the humectant is betaine or glycerol. According to the high-moisture-retention NMN hydrophilic gel disclosed by the invention, through transdermal absorption, the problems that oral NMN is unstable when encountering acid and is easy to degrade and damage are solved, and the bioavailability is directly improved. According to the high-moisture-retention NMN hydrophilic gel disclosed by the invention, proper auxiliary materials are selected, and scientific dosage ratio is combined, so that the obtained gel can be quickly absorbed by skin and takes effect quickly; the effects of abating fever and relieving have a good effect on acute skin injury (such as allergy, acne and bruise), and the patient compliance is good. Due to the jelly state of the NMN hydrophilic gel and the effect of the humectant, medicine components are not prone to water loss and precipitation, and the effect is more lasting.

Description

technical field [0001] The invention relates to a moisturizing NMN hydrophilic gel and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Biologists have found that the level of NAD in the human body will gradually decrease with the increase of age, and the research has concluded that the reduction of NAD level in the body is the root cause of aging, which in turn causes aging problems. When the NAD content is added, these problems will be improved. NAD is an important coenzyme in the body, which participates in one-fourth of the physiological activities in the human body, and is also an indispensable chemical substance for the production of kinetic energy of cell membrane proteins and the maintenance of long-lived protein vitality. Therefore, the reduction of NAD levels will cause various aspects of the body harm, causing human aging and disease. Anti-aging scientific research has found that after t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/706A61K47/18A61K47/26A61K47/36A61P17/16A61P17/18
CPCA61K31/706A61K9/06A61K9/0014A61K47/36A61K47/26A61K47/186A61P17/18A61P17/16
Inventor 蔡正军张然杨扬
Owner 药酚享科技北京有限公司
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