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Application of mixed crystalline semiconductor nanoparticles as substrate of surface enhanced laser Raman spectroscopy

A technology of laser Raman spectroscopy and nano-particles, which is applied in the field of nano-materials, can solve the problems of weak enhancement factors and obstacles to wide application, and achieve high Raman sensitivity, improve detection sensitivity, and highly selective surface-enhanced Raman scattering effect Effect

Pending Publication Date: 2022-03-01
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, semiconductor materials as SERS substrates are relatively weak enhancement factors, which hinders their wide application

Method used

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  • Application of mixed crystalline semiconductor nanoparticles as substrate of surface enhanced laser Raman spectroscopy
  • Application of mixed crystalline semiconductor nanoparticles as substrate of surface enhanced laser Raman spectroscopy
  • Application of mixed crystalline semiconductor nanoparticles as substrate of surface enhanced laser Raman spectroscopy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] (1) Preparation of spherical black titanium dioxide with surface-enhanced Raman scattering (SERS) function

[0151] At room temperature, 4.0 g TiO 2 Nanoparticle powder (P25, anatase, rutile) with 1.5 g NaBH 4 Mix and grind the mixture thoroughly for 30 minutes. The mixture was then transferred to a porcelain boat, placed in a tube furnace, heated from room temperature to 350 °C at a rate of 10 °C / min under an Ar atmosphere, and then kept for 60 min. After natural cooling to room temperature, simply wash several times with deionized water and ethanol to remove unreacted NaBH 4 , and dried at 70 °C to obtain black titanium dioxide. The particle diameter of described black titanium dioxide is 25nm, and the TEM figure of the black titanium dioxide that prepares is as follows figure 2 As shown, it can be seen that black titanium dioxide has a crystal core amorphous shell structure, and the core shell ratio parameter is 25.

[0152] (2) Black titanium dioxide (B-TiO2) ...

Embodiment 2

[0161] (1) Preparation of black ZnO nanosheets with SERS function

[0162] At room temperature, mix 4.0g of ZnO crystal particle powder with 1.5g of NaBH 4 Mix and grind the mixture thoroughly for 30 minutes. The mixture was then transferred to a porcelain boat, placed in a tube furnace, heated from room temperature to 350 °C at a rate of 10 °C / min under an Ar atmosphere, and then kept for 60 min. After natural cooling to room temperature, simply wash several times with deionized water and ethanol to remove unreacted NaBH 4 , and dried at 70°C to obtain black zinc oxide. The particle size of the black zinc oxide is 25nm. It can be seen that the black zinc oxide has a crystal core amorphous shell structure, and the core-shell ratio parameter is 25.

[0163] Other preparation processes of the mixed crystalline ZnO-AR-rBSA-FA composite nanomaterial in Example 2 are the same as in Example 1.

Embodiment 3

[0165] (1) Preparation of black spherical ferric oxide with SERS function

[0166] At room temperature, mix 4.0g ferric oxide crystalline powder with 1.5g NaBH 4 Mix and grind the mixture thoroughly for 30 minutes. The mixture was then transferred to a porcelain boat, placed in a tube furnace, heated from room temperature to 350 °C at a rate of 10 °C / min under an Ar atmosphere, and then kept for 60 min. After natural cooling to room temperature, simply wash several times with deionized water and ethanol to remove unreacted NaBH 4 , and dried at 70°C to obtain black ferric oxide. The particle size of the black ferroferric oxide is 25nm. It can be seen that the black ferric ferric oxide has a crystal core amorphous shell structure, and the core-shell ratio parameter is 25.

[0167] Mixed crystalline Fe in embodiment 3 3 o 4 -Other preparation processes of the AR-rBSA-FA composite nanomaterial are the same as in Example 1.

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Abstract

The invention discloses an application of mixed crystalline semiconductor nanoparticles as a substrate for surface enhanced laser Raman spectroscopy. According to the application of the mixed crystalline semiconductor nanoparticles as the substrate of the surface-enhanced laser Raman spectroscopy, the mixed crystalline semiconductor nanoparticles are selected from metal oxides with a crystal and non-crystal combined structure. The mixed crystalline semiconductor nanoparticles not only have a high-selectivity surface enhanced Raman scattering effect, but also have higher surface enhanced Raman sensitivity than semiconductor crystals, and are beneficial to improving the biological detection sensitivity.

Description

technical field [0001] The application relates to the application of mixed crystalline semiconductor nanoparticles as a substrate for surface-enhanced laser Raman spectroscopy, and belongs to the technical field of nanomaterials. Background technique [0002] Malignant tumors (cancer) have become one of the major public health problems that seriously threaten the health of the Chinese population. According to the latest statistics, the death of malignant tumors accounts for 23.91% of all the causes of death among residents, and the incidence and mortality of malignant tumors have shown an increase in the past ten years. Continue to rise. Relevant data show that the survival rate of patients with early stage cancer after cure is above 80%, while the 5-year survival rate of patients with mid-stage cancer is relatively low. Therefore, developing a method for early detection and treatment of tumors has become a problem of common concern throughout the world. Traditional clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65C01G23/047C01G9/02C01G49/08C01G19/02C01F17/235C01F17/10C01G39/02C01G3/02B82Y40/00B82Y30/00
CPCG01N21/658C01G23/08C01G9/02C01G49/08C01G19/02C01F17/235C01F17/10C01G39/02C01G3/02B82Y40/00B82Y30/00C01P2004/32C01P2004/24C01P2004/30C01P2004/16C01P2004/41C01P2004/39C01P2004/64C01P2004/62C01P2004/61
Inventor 林杰徐夏薇吴爱国何孟
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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