Water-based polyurethane liquid dressing and preparation method thereof and antibacterial film layer

Abstract

The invention relates to the technical field of medical materials, in particular to a water-based polyurethane liquid dressing and a preparation method thereof and an antibacterial film layer. According to the invention, a certain amount of hydramine, hydroxymethyl carboxylic acid and sodium sulfonate are introduced as hydrophilic chain extenders in a process of preparing a polyurethane prepolymer, so that the polyurethane prepolymer can be subjected to proper hydrophilic modification, and can be used as a film forming substance of the water-based liquid dressing; by introducing a certain amount of an antibacterial agent capable of chemically reacting with polyisocyanate, the antibacterial agent is introduced into a polymer chain segment in a chemical grafting manner and is not easy to lose into the environment to cause microbial drug resistance, and the long-term antibacterial effect of the dressing is realized; and the introduction of the antibacterial agent also improves the crosslinking density of polyurethane to a certain extent, and maintains thecrosslinking density within a reasonable range, so that the dressing has certain water resistance after film formation while the dressing also has relatively good air permeability.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a water-based polyurethane liquid dressing, a preparation method thereof, and an antibacterial film layer. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. Traditional wound dressings, such as bandages, have the functions of covering wounds and preventing infection, but these traditional dressings have disadvantages such as poor comfort, hindering blood circulation, inability to completely isolate bacteria, and easy adhesion of wounds during removal, so they are widely used in clinical applications. However, liquid wound dressings have the advantages of arbitrary spraying, film-forming, transparent and waterproof, and do not affect the appearance of users, so they are more and more ...

AI Technical Summary

Problems solved by technology

However, most of the dressings involving the use of polyurethane on the market are solid dressings, only using polyurethane as the foaming layer, rarely using polyurethane as the film-forming substance of liquid dressings, even if there are a few using polyurethane as the film-forming substance of liquid dressings, in view of The hydrophobicity of polyurethane is also an oily liquid dressing instead of a mild and non-irritating water-based liquid dressing

However, traditional water-based dressings are mild and non-irritating, but their water resistance and long-lasting antibacterial and antibacterial properties are insufficient, and their protective effect on wounds is weak

[0004] In addition, in order to increase the active antibacterial performance of liquid dressings, so that it is not limited to the physical barrier to bacteria and viruses, some antibacterial components are often added to the dressing through physical mixing, but the antibacterial agents added through physical mixing are easy to be removed from the film-forming substances. Leakage will cause surface environmental pollution, cause bacterial resistance, and may even cause "super bacteria"; and after the antibacterial agent continues to leak completely, the film-forming material of the liquid dressing no longer has antibacterial effect. Therefore, through physical sharing It is difficult for liquid dressings mixed with antibacterial agents to have long-term antibacterial and bactericidal effects

Images