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Preparation for improving anemia symptoms and preparation method thereof

A preparation and symptom technology, which is applied in the field of preparations and preparations for improving anemia symptoms, can solve the problems of poor safety and poor absorption rate, and achieve the effects of high safety, increasing cAMP content, and enhancing NK cell activity

Pending Publication Date: 2022-02-08
杭州佰倍优生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese Society of Clinical Oncology Clinical Practice Guidelines for Tumor-Related Anemia 2021 found that traditional iron supplementation has the disadvantages of poor absorption rate (about 10%) and poor safety

Method used

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  • Preparation for improving anemia symptoms and preparation method thereof
  • Preparation for improving anemia symptoms and preparation method thereof
  • Preparation for improving anemia symptoms and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 100g blood protein peptide powder, 100g collagen peptide powder, 100g jujube extract, 2g taurine, 0.2g sucralose, 0.15g steviol glycoside, 1g erythritol, 6g citric acid, 0.5g pectin, 1.5g Food essence, 1g ginseng powder and 1g donkey-hide gelatin peptide powder were mixed and stirred, sieved, granulated and then tableted, and the compound coating agent was added for coating to obtain the blood protein polypeptide preparation in sheet form.

Embodiment 2

[0041] 100g blood protein peptide powder, 100g collagen peptide powder, 100g jujube extract, 2g taurine, 0.2g sucralose, 0.15g steviol glycoside, 1g erythritol, 6g citric acid, 0.5g pectin, 1.5g Food essence, 1g ginseng powder and 1g donkey-hide gelatin powder were mixed and stirred, then 680.6g of water was added to dissolve and set to volume for 5 hours, filtered and then UHT sterilized, sterilized for 2 hours, then filled and sealed, and the liquid level was checked by light inspection , foreign matter monitoring, and then spray codes on the bottle caps, and then perform secondary sterilization. After labeling, they will be inspected by lights again and automatically packed into boxes, weighed, and put into storage.

Embodiment 3

[0042] Embodiment 3: Blood albumin polypeptide is to the animal experiment of iron-deficiency anemia

[0043] The blood protein polypeptide powder in the preparation of the present invention is used to intervene IDA rats, and the blood index, body weight and protein nutrition will be studied to study the preventive effect of blood protein polypeptide on rat IDA.

[0044] 1 Experimental materials and instruments

[0045] 11 Experimental materials

[0046] 111 Laboratory animals

[0047] Wistar strain rats, 4 weeks old, weighing 60±6g, male and female, in good health.

[0048] During the feed preparation process, iron pollution was strictly controlled, and the utensils holding the feed were soaked overnight in nitric acid, and rinsed repeatedly with deionized water.

[0049] 12 experimental equipment

[0050] Micro-sampler (MC, Shanghai Anting Micro-sampler Factory); stainless steel heating plate (DB-Ⅲ, Shandong Echeng Jiade Instrument Factory); muffle furnace (Tianjin Scien...

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Abstract

The invention discloses a preparation for improving anemia symptoms and a preparation method of the preparation, belonging to the technical field of blood protein polypeptides. The preparation for improving anemia symptoms comprises the following components in parts by weight: 3 to 10 parts of blood protein polypeptide powder, 3 to 10 parts of collagen peptide powder, 3 to 10 parts of red date extract, 0.1 to 0.3 part of taurine, 0.01 to 0.04 part of sucralose, 0.015 to 0.025 part of stevioside, 0.1 to 0.3 part of erythritol, 0.6 to 0.8 part of citric acid, 0.05 to 0.15 part of pectin, 0.15 to 0.18 part of edible essence, 0.1 to 0.2 part of ginseng powder and 0.1 to 0.2 part of donkey-hide gelatin peptide powder. The preparation is high in absorptivity, free of accumulation, high in safety and free of gastrointestinal irritation, and effectiveness and safety of the preparation are proved by rat experiments. The preparation can effectively improve anemia indexes for anemia, especially tumor-related anemia, and has a very remarkable erythropoiesis effect under the condition that a patient does not receive a hemopoietin promotion injection during a test taking period.

Description

technical field [0001] The invention relates to the technical field of blood protein polypeptides, in particular to a preparation for improving anemia symptoms and a preparation method thereof. Background technique [0002] Cancer-related anemia (cancer related anemia, CRA) is anemia that occurs in cancer patients themselves or during treatment, and is one of the common complications. The prevalence of CRA is 30% to 90%. It can significantly affect the clinical treatment effect of tumors and the survival period of patients, and it is also a negative factor affecting disease progression, prognosis and survival rate. Among different types of tumors, the incidence of anemia is high in patients with lung cancer, gynecology, genitourinary system and gastrointestinal digestive system tumors. CRA patients (Hb range, 8-10g / dl) will show fatigue, lethargy, dyspnea, anorexia, difficulty concentrating, etc.; anemia can impair their overall functional status and significantly reduce t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K36/725A61P7/06A61P35/00C12P21/06C07K14/805C07K1/14C07K1/34
CPCA61K38/1709A61K36/725A61P7/06A61P35/00C12P21/06C07K14/805A61K2300/00
Inventor 王阿琴余钧曹鑫杨静春
Owner 杭州佰倍优生物科技有限公司
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