Polymolecular marker and device for clinically evaluating sensitivity of ulcerative colitis patient to golimumab

A technology for ulcerative colitis and golimumab, which is applied in the field of biomedicine, can solve problems such as difficult to predict sensitive or reactive, and needs further research, and achieves short detection period, high accuracy and broad clinical application. and the effect of scientific research value

Inactive Publication Date: 2022-02-01
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with infliximab and adalimumab, golimumab has a more stable structure and a stronger binding ability to TNF-α. The maintenance of remission research trial has also been approved by the FDA for the treatment of moderate to severe ulcerative colitis, but it is still difficult to predict which ulcerative colitis patients are sensitive or responsive to golimumab, and how to predict ulcerative colitis Sensitivity and / or responsiveness to golimumab in patients with inflammatory disease remains to be further studied

Method used

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  • Polymolecular marker and device for clinically evaluating sensitivity of ulcerative colitis patient to golimumab
  • Polymolecular marker and device for clinically evaluating sensitivity of ulcerative colitis patient to golimumab
  • Polymolecular marker and device for clinically evaluating sensitivity of ulcerative colitis patient to golimumab

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Screening 1. Data Source and Screening Method for Genes Related to Ulcer Colitis Resistance Sensitivity

[0067] A total of 59 patients with ulcerative colitis were collected, and the colon mucosal tissue samples of patients with ulcerative colitis were collected before Gobeli monocharmonic (golimumab). In this study, patients with ulcerative colitis were ulcerative colitis in moderate to severe activity. Gobley monoclonal can promote clinical relief and mucosa hevities of ulcerative colitis and reduce disease aggravation risk and surgical rate. Has been widely used in clinical application. It is clinically administered to the above ulcerative colitis patient, according to the above ulcerative colitis, there is no response to Gobley monoclonal anti-drug, and the ulcerative colitis is divided into reaction group ( R, responder, and non-reable group (NR, non-responder), where the reaction group includes ulcerative colitis in patients with complete reactions (Cr, Com...

Embodiment 2

[0071] Example 2 Application of Potential Logo Molecules in Patients with Ulcerative Colitis on Goblim Montack Drug Sensitivity

[0072] 1, experimental method

[0073] For a gene that is screened in Example 1, a gene that is differentially expressed between Gobley monoclonal anti-drugs and the difference between Gobeli monoclonal drug without reacting groups, using the R bag "proc" (version 1.15.0) Subject working curve (ROC curve), calculates the underlying area of ​​the subject's working characteristic curve (AUC) to assess a single differential expression gene, any two differential expression genes, three differentially expressed genes, respectively, predicted ulcerative colitis, respectively. The patient's accuracy of sensitivity of Goblim monochastic drugs;

[0074] When it is judged that a single gene is used to predict the diagnostic efficacy and accuracy of the sensitivity of Goblim monochastitis, the expression level of the single gene is directly used, and the maximum c...

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Abstract

The invention discloses a polymolecular marker and a device for clinically evaluating the sensitivity of ulcerative colitis patients to golimumab, wherein the polymolecular marker comprises CPB1, IL1B and / or SRGN, and the accuracy of predicting the sensitivity of the ulcerative colitis patients to the golimumab is high; and the polymolecular marker can be used for monitoring the sensitivity of the ulcerative colitis patients to golimumab in real time before and after treatment, so that clinical doctors can conveniently adopt personalized treatment schemes in time, and blind medication is avoided.

Description

Technical field [0001] The present invention belongs to the field of biomedical technology. Background technique [0002] Ulcerative Colitis (UC) is a complicated colon inflammatory disease, mainly in diarrhea, blood, and mucus pus, severe patients with high heat and poisoning symptoms (Watanabe Y, Murata) T, Amakawa M, et al.KAG-308, a newly-identified EP4-selective agonistshows efficacy for treating ulcerative colitis and can bring about lower riskof colorectal carcinogenesis by oral administration [J] .European journal ofpharmacology, 2015,754: 179- 189.), with the characteristics of attack, alleviation and recurrence of alternating diseases, more common in 20-40 years old young people, is a common disease, multiple disease, and difficult disease. Its pathological manifestation is a mucosa and mucosa-containing cell infiltration, forming multiple ulcers, and has a certain association with colon cancer. Ulcerative colitis lesions mainly involve the mucosa and mucosa of the colo...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883G01N33/6893C12Q2600/106C12Q2600/158G01N2800/065G01N2800/60G01N2800/52
Inventor 杨承刚王丹范冰燕郭静李雨晨
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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