Cyclodextrin derivative and preparation method thereof

Abstract

The invention provides a preparation method of a cyclodextrin derivative. The preparation method comprises the following steps: a) preparing a cyclodextrin derivative crude product liquid, and removing impurities to obtain a cyclodextrin derivative aqueous solution; b) adjusting the concentration of the cyclodextrin derivative aqueous solution in step a) to be 5 wt% or above, and carrying out self-aggregation under a stirring condition to obtain a cyclodextrin derivative feed liquid; and c) carrying out spray drying on the feed liquid to obtain the cyclodextrin derivative. After the cyclodextrin derivative is prepared and before spray drying, the cyclodextrin derivative is treated, so that the cyclodextrin derivative is self-aggregated, the surface appearance of the obtained cyclodextrin derivative is regular, round and smooth, the dissolving speed of the cyclodextrin derivative in water is increased, and the problems that the cyclodextrin derivative is easy to absorb moisture when being stored, easy to raise dust when being taken, and low in water dissolving speed and when a high-concentration aqueous solution is prepared, the materials are agglomerated and the like can be solved without using specific equipment.

Description

technical field [0001] The invention relates to the technical field of organic polymer compounds, in particular to a cyclodextrin derivative and a preparation method thereof. Background technique [0002] Supramolecular chemistry, which studies the interaction between host and guest, has won the Nobel Prize twice in the past 30 years, showing a strong momentum of development. In 1987, the Nobel Prize in Chemistry was awarded to three chemists, J.M.Lehn (University of Strasbourg, France), C.J.Pedersen, and D.J.Cram, in recognition of their pioneering work in the basic theory of supramolecular chemistry; The Bell Prize in Chemistry was awarded to J.P.Sauvagen (University of Strasbourg, France), J.F.Stoddart (Northwestern University), and B.L.Feringa (University of Groningen, Netherlands) for their outstanding contributions in the field of molecular machines in host-guest chemistry. As one of the main molecules of supramolecular chemistry, cyclodextrin represented by formula (...

AI Technical Summary

Problems solved by technology

However, when the dry powder is dissolved in water, especially when a large-concentration aqueous solution is prepared, it is very easy for the material to agglomerate, and the dry powder floats on the water surface; during the stirring process, the floating dry powder is easily disturbed by the stirring mechanical force and floats in the air, and the dissolution takes a long time. affect the use of materials

In addition, due to the hygroscopicity, the sulfoalkyl cyclodextrin needs to be used quickly after the packaging bag is opened, otherwise it will absorb the moisture in the air and cause the deviation of material weighing and the decrease of cleanliness

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