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Co-production process for desalted intestinal mucosa protein powder and heparinoid

A technology of intestinal mucosa and protein powder is applied in the field of co-production process of desalted intestinal mucosa protein powder and heparinoid, which can solve problems such as environmental protection and production and operation problems, and achieve the effect of reducing production costs.

Active Publication Date: 2021-12-21
潢川县鹏升畜产品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical status of the above-mentioned industry has brought great troubles to the environmental protection and production and operation of upstream crude heparin sodium enterprises. Therefore, it is urgent to develop an efficient co-production process to increase the added value of products and promote high-quality development.

Method used

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  • Co-production process for desalted intestinal mucosa protein powder and heparinoid
  • Co-production process for desalted intestinal mucosa protein powder and heparinoid
  • Co-production process for desalted intestinal mucosa protein powder and heparinoid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A co-production process of desalted intestinal mucosal protein powder and heparin, comprising the following characteristic steps:

[0019] The process steps of desalted intestinal mucosal protein powder are:

[0020] S1. Collect 500L of salt-containing protein waste water in the production process of crude heparin sodium as raw material liquid, transfer the raw material liquid to the turnover box, filter it through the ceramic membrane with a pore size of 10KD, and add purified water to the turnover tank during the filtration process Keep the volume of the raw material liquid unchanged, and detect the change of the salinity of the raw material liquid at the same time. When the detected salinity of the raw material liquid drops below 0.1%, no longer add purified water to the turnover tank, and continue to filter and concentrate until the volume of the raw material liquid is 100L is the retentate, which is concentrated desalted intestinal mucosal protein solution;

[002...

Embodiment 2

[0039] A co-production process of desalted intestinal mucosal protein powder and heparin, comprising the following characteristic steps:

[0040] The process steps of desalted intestinal mucosal protein powder are:

[0041] S1. Collect 500L of saline protein waste water from the production process of crude heparin sodium as the raw material liquid, transfer the raw material liquid to the turnover box, filter it through a ceramic membrane with a pore size of 30KD, and add purified water to the turnover tank during the filtration process Keep the volume of the raw material liquid constant, and detect the salinity change of the raw material liquid at the same time. When the detected salinity of the raw material liquid drops below 0.1%, no longer add purified water to the turnover tank, and continue to filter and concentrate until the volume of the raw material liquid is 100L is the retentate, which is concentrated desalted intestinal mucosal protein solution;

[0042]S2. Add 400...

Embodiment 3

[0057] A co-production process of desalted intestinal mucosal protein powder and heparin, comprising the following characteristic steps:

[0058] The process steps of desalted intestinal mucosal protein powder are:

[0059] S1. Collect 500L of saline protein waste water from the production process of crude heparin sodium as the raw material liquid, transfer the raw material liquid to the turnover box, filter it through a ceramic membrane with a pore size of 30KD, and add purified water to the turnover tank during the filtration process Keep the volume of the raw material liquid unchanged, and detect the change of the salinity of the raw material liquid at the same time. When the detected salinity of the raw material liquid drops below 0.1%, no longer add purified water to the turnover tank, and continue to filter and concentrate until the volume of the raw material liquid is 100L is the retentate, which is concentrated desalted intestinal mucosal protein solution;

[0060] S2...

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Abstract

The invention relates to the technical field of biology, in particular to a co-production process for desalted intestinal mucosa protein powder and heparinoid. According to the process, salt-containing protein wastewater generated in the production process of crude heparin sodium is adopted as a raw material, and co-production of desalted intestinal mucosa protein and high-quality heparinoid is realized by adopting a ceramic membrane filtration technology, a biological enzyme degradation technology and a low-temperature acid precipitation technology respectively. The process comprises the following steps: circularly filtering salt-containing protein wastewater generated in the production process of crude heparin sodium, carrying out precipitating with an organic solvent, and successively carrying out drying and crushing to obtain desalted intestinal mucosa protein powder; and collecting a filtrate obtained after circulating filtration, conducting further filtering and concentrating, and sequentially carrying out nuclease degradation, low-temperature acid precipitation, hydrogen peroxide oxidation, low-power precipitation, drying and crushing to obtain the heparinoid. The co-production process is beneficial to discharge of wastewater containing little salt and the like, improves the added value of the products, and has important economic value.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a co-production process of desalted intestinal mucosal protein powder and heparinoid. Background technique [0002] Heparin is the most effective and clinically used anticoagulant drug in the world, and it is mainly used in the treatment of cardiovascular and cerebrovascular diseases and hemodialysis. In addition to its anticoagulant and antithrombotic effects, heparin also has various biological activities such as anti-tumor metastasis, anti-inflammation, immune regulation, hypolipidemic, anti-medial smooth muscle cell (SMC) proliferation, and promotion of fibrinolysis. Heparin molecules are composed of a series of glycosaminoglycan molecules with complex structures, and it is still not possible to produce them on a large scale through artificial synthesis or biological fermentation methods. The current pharmacopoeias of various countries stipulate that the raw materials required f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08H1/00C08B37/00
CPCC08H1/00C08B37/0063C08B37/0003
Inventor 余璞斐徐袁陈讲一袁俊威黄帅
Owner 潢川县鹏升畜产品有限公司
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