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Drug delivery system, and preparation method and application of drug delivery system

A drug delivery system, magnetic nanotechnology, applied in the direction of pharmaceutical formulations, preparations for in vivo tests, drug delivery, etc., can solve the problem of clear comparison of small metastases, precise positioning of systemic metastases, penetration depth and Issues such as insufficient soft tissue resolution

Pending Publication Date: 2021-12-17
LISHUI CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, MRI contrast agents are not specific enough when used in vivo, and it is difficult to achieve a clear contrast between micrometastases and surrounding normal tissues, which can easily lead to missed diagnosis. In addition, it is difficult to achieve comprehensive and accurate positioning of systemic metastases with a single MRI scan.
The near-infrared two-zone imaging technology can realize the precise positioning of the whole body lesion in one imaging, but its application is limited due to the impact of its penetration depth and insufficient soft tissue resolution.

Method used

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  • Drug delivery system, and preparation method and application of drug delivery system
  • Drug delivery system, and preparation method and application of drug delivery system
  • Drug delivery system, and preparation method and application of drug delivery system

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preparation example Construction

[0050] This embodiment also provides a method for preparing a drug delivery system, including:

[0051] S1. Preparation of magnetic nanometers; including synthesis of oleic acid-modified oil-soluble magnetic nanometer Fe by thermal decomposition 3 o 4 ;

[0052] S2. Preparation of down-converting rare earth nanometers;

[0053] S3, preparation of CREKA-PEG2000-DSPE (distearoylphosphatidylethanolamine-polyethylene glycol-tumor targeting protein);

[0054] S4. Preparation of CREKA-modified co-loading down-conversion rare earth nano / magnetic nano liposomes by thin film hydration method.

[0055] Among them, the preparation of S1 magnetic nanometers includes:

[0056] Dissolve 2mmol of Fe(acac)3 (iron triacetylacetonate), 5mmol of 1,2-dodecanediol, 6mmol of oleic acid, and 6mmol of oleylamine in 20mL of dibenzyl ether at room temperature, and blow nitrogen into it at 200 After reacting at ℃ for 30 minutes, continue to react at 265℃ for 30 minutes, cool down at room temperatur...

Embodiment 1

[0075] S1, the oil-soluble SPIO that adopts thermal decomposition to synthesize oleic acid modification: Fe(acac) 3 (2mmol), 1,2-dodecanediol (5mmol), oleic acid (6mmol) and oleylamine (6mmol) normal temperature Dissolve in 20 mL of dibenzyl ether, blow nitrogen, react at 200°C for 30 minutes, continue to react at 265°C for 30 minutes, cool down at room temperature, collect the black product with a magnet, wash with ethanol several times to obtain oleic acid-modified SPIO.

[0076] The morphology of SPIO nanoparticles was observed by transmission electron microscope. refer to figure 1 , Weigh a certain amount of nanoparticles and disperse them in chloroform to obtain a nanoparticle solution with a concentration of 0.1mg / mL, then drop the sample on a copper grid covered with a carbon film, dry it at room temperature and pass it through a transmission electron microscope (80kV) It can be observed that the shape of the nanoparticles is regular hexagonal, and the particle size is...

Embodiment 2

[0088] S1, the oil-soluble SPIO that adopts thermal decomposition to synthesize oleic acid modification: Fe(acac) 3 (2mmol), 1,2-dodecanediol (5mmol), oleic acid (6mmol) and oleylamine (6mmol) normal temperature Dissolve in 20 mL of dibenzyl ether, blow nitrogen, react at 200°C for 30 minutes, continue to react at 265°C for 30 minutes, cool down at room temperature, collect the black product with a magnet, wash with ethanol several times to obtain oleic acid-modified SPIO.

[0089] The morphology of SPIO nanoparticles was observed by transmission electron microscope. Weigh a certain amount of nanoparticles and disperse them in chloroform to obtain a nanoparticle solution with a concentration of 0.1mg / mL, then drop the sample on a copper grid covered with a carbon film, dry it at room temperature, and pass it through a transmission electron microscope (80kV). It was observed that the shape of the nanoparticles was regular hexagonal, and the particle size was about 7nm, which wa...

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Abstract

The invention provides a preparation method of a drug delivery system. The preparation method comprises the following steps of: preparing magnetic nanoparticles, wherein preparation of the magnetic nanoparticles comprises the step of synthesizing oleic acid modified oil-soluble magnetic nanoparticles Fe3O4 by adopting a thermal decomposition method; preparing down-conversion rare earth nanoparticles; preparing CREKA-PEG2000-DSPE; and preparing CREKA modified co-loaded down-conversion rare earth nano / magnetic nano liposome by adopting a film hydration method. According to the tumor specific targeting polypeptide CREKA modified co-loaded down-conversion rare earth nano / magnetic nano liposome drug delivery system prepared by the invention, homing peptides selected by using an in-vivo phage technology through CREKA on the surface of the drug delivery system can be in specific binding with targeted malignant tumor interstitial substance overexpressed FFC, so that MRI / NIR-II fluorescent bimodal imaging of malignant tumors at the FFC molecular level is realized, so that more comprehensive diagnosis information is obtained, and a possibility is provided for early accurate diagnosis of breast cancer. The invention further provides a drug delivery system and application.

Description

technical field [0001] The invention relates to the technical field of nano-biological materials, in particular to a drug delivery system, a preparation method and an application of the drug delivery system. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. According to the latest research published in CA Magazine in 2018, its morbidity and mortality rank first and fifth among female malignant tumors, with nearly 2.1 million new cases every year. And caused the death of more than 620,000 patients. In recent years, with the increase in the diagnosis rate of early breast cancer, the improvement of surgical methods and the application of comprehensive treatment, the cure rate of breast cancer has increased. Therefore, improving the detection rate of early breast cancer will greatly improve the survival period of patients. [0003] The emergence of molecular imaging technology provides a method for the detection and diagnosis of m...

Claims

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Application Information

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IPC IPC(8): A61K49/14A61K49/18A61K49/00
CPCA61K49/14A61K49/1812A61K49/0002A61K49/0056A61K49/0084Y02A50/30
Inventor 纪建松张南南杜永忠陈敏江殳高峰赵中伟方世记郑丽云陈为谦
Owner LISHUI CENT HOSPITAL
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