Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Glass based on amino acids as well as preparation method and application thereof

An amino acid and glass technology, which is applied in the preparation method of peptides, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve the undisclosed problems of amino acid-based biomolecular glass materials and preparation methods, and achieve environmental friendliness , high biocompatibility, and highly reproducible results

Active Publication Date: 2021-12-07
INST OF PROCESS ENG CHINESE ACAD OF SCI
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Amino acid-based biomolecular glass materials and preparation methods have not yet been disclosed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glass based on amino acids as well as preparation method and application thereof
  • Glass based on amino acids as well as preparation method and application thereof
  • Glass based on amino acids as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] A kind of preparation method of glass based on lysine comprises the steps:

[0107] (1) Weigh 20 mg of N-acetyl-L-lysine (Ac-Lys) powder, place it in a mortar and grind it evenly, then transfer it to a crucible;

[0108] (2) the crucible that Ac-Lys powder is housed in step (1) is in N 2 placed in the heating equipment under the atmosphere;

[0109] (3) heat treatment is carried out to the equipment of step (2), with 10K min -1 The heating rate of the crucible is raised from room temperature to 600K temperature, and the temperature is kept at this temperature for 10 minutes;

[0110] (4) The equipment of step (3) is cooled down, with 10K min -1 The cooling rate will reduce the crucible to 273.15K temperature;

[0111] (5) Transfer the sample in step (4) to an annealing furnace with a temperature of 283.15K, keep the temperature constant for 20 minutes, and perform glass annealing treatment to obtain Ac-Lys glass.

[0112] figure 1 It is the physical picture of the...

Embodiment 2

[0116] A kind of preparation method of the peptide glass based on phenylalanine comprises the steps:

[0117] Weigh 50 mg of benzyloxycarbonyl-phenylalanyl-phenylalanyl (Z-Phe-Phe) powder, place it in a mortar and grind it evenly, then transfer it to a crucible;

[0118] (2) the crucible that Z-Phe-Phe powder is housed in step (1) is in N 2 placed in the heating equipment under the atmosphere;

[0119] (3) heat treatment is carried out to the equipment of step (2), with 40K min -1 The heating rate of the crucible is raised from room temperature to 500K temperature, and the temperature is kept at this temperature for 20 minutes;

[0120] (4) The equipment of step (3) is cooled down, with 50K min -1 The cooling rate will reduce the crucible to 273.15K temperature;

[0121] (5) Transfer the sample in step (4) to an annealing furnace at a temperature of 283.15K, keep the temperature constant for 10 minutes, and perform glass annealing treatment to obtain Z-Phe-Phe glass.

[0...

Embodiment 3

[0126] A kind of preparation method of glycine-based glass comprises the steps:

[0127] (1) Weigh 30 mg of N-tert-butoxycarbonyl-L-glycine (Boc-Gly) powder, place it in a mortar and grind it evenly, then transfer it to a crucible;

[0128] (2) the crucible that Boc-Gly is housed in step (1) is in N 2 placed in the heating equipment under the atmosphere;

[0129] (3) heat treatment is carried out to the equipment of step (2), with 10K min -1 The heating rate of the crucible is raised from room temperature to 600K temperature, and the temperature is kept at this temperature for 30 minutes;

[0130] (4) The equipment of step (3) is cooled down, with 10K min -1 The cooling rate will reduce the crucible to 273.15K temperature;

[0131] (5) Transfer the sample in step (4) to an annealing furnace at a temperature of 283.15K, keep the temperature constant for 30 minutes, and perform glass annealing treatment to obtain Boc-Gly glass.

[0132] Figure 7 The pictures of Boc-Gly po...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
transparencyaaaaaaaaaa
transparencyaaaaaaaaaa
Login to View More

Abstract

The invention discloses biodegradable glass based on amino acids, peptides and derivatives, and a preparation method and application thereof. Main raw materials of the glass are one or a combination of more of amino acids, peptides and derivatives or salts thereof. Compared with traditional glass, the glass disclosed by the invention has the remarkable advantages of high biocompatibility, biodegradability, 3D printing, composting and the like, the preparation process is simple and green, and the influence of the traditional glass on the ecological environment can be effectively avoided; and the glass is widely applied to the fields of medicines, building materials, chemical engineering, food, electronics, national defense and the like, including but not limited to tissue engineering, tooth / skeleton repair, drug sustained release, cell / protein sealing, optical fiber communication, coatings, precise instruments and the like.

Description

Technical field: [0001] The invention discloses a glass material, its preparation method and application, in particular to an amino acid-based biomolecular glass, its preparation method and application, and belongs to the field of new materials. Background technique: [0002] Glass is generally prepared from inorganic minerals such as silica and calcium carbonate as the main raw material, and is one of the most commonly used materials in daily life. Glass is hardly degradable under natural conditions and is easily broken. Therefore, no matter in terms of pollution, hazards, or permanence, the impact of glass on the environment and ecology is significant. [0003] Various glass materials, products and manufacturing methods thereof have been disclosed. For example, a manufacturing method of silicate glass, silicate glass and silica raw material for silicate glass have been disclosed (WO2015 / 129495 JA 2015.09. 03); a glass product (WO2005 / 058766 EN2005.06.30) with β-quartz or ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/47C07C271/22A61K47/18A61K47/42C07K1/00B33Y70/00
CPCC07C233/47C07C271/22A61K47/183A61K47/42C07K1/00B33Y70/00Y02P20/55
Inventor 闫学海邢蕊蕊袁成前
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com