Biological introduction aid and method of use thereof

A technology of organisms and adjuvants, applied in the field of compositions containing active substances, preventing and/or treating diseases, or compositions for improving physical fitness and/or physical conditions, can solve the problem of improving the efficiency of introduction, without evidence and other issues, to achieve the effect of improving physical fitness and/or physical condition

Pending Publication Date: 2021-12-03
真共生株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, until now, there has been almost no technical idea of ​​using a solution containing microbubbles (so-called nanobubble water) to introduce bacteria into living organisms in a living state, and there is no evidence that actually improves the efficiency of introduction into organisms.

Method used

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  • Biological introduction aid and method of use thereof
  • Biological introduction aid and method of use thereof
  • Biological introduction aid and method of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0329] Hereinafter, the present invention will be described in more detail using examples, comparative examples, etc., but the present invention is not limited by these examples.

[0330] In addition, before describing Examples etc., the "microorganism detection method" used in Examples etc. is demonstrated.

[0331] (Detection method of microorganisms)

[0332] The determination of the number and type of microorganisms was carried out by combining known "ribosome profiling (16S ribosomal RNA (rRNA) sequencing)" and known "next generation sequencer (Next Generation Sequencer: NGS)".

[0333] It should be noted that, as a profiling method, in addition to "ribosome profiling", "shotgun metagenomics sequence" that comprehensively analyzes the entire genome of all microorganisms present in the subject can also be used et al. have used "ribosome profiling" which can be performed at low cost with a small number of sequences.

[0334] (Ribosome Profiling)

[0335] The so-called "r...

Embodiment A

[0341] [Example A: Biointroduction Auxiliary A (Containing Air Bubbles Below Nano Size)]

[0342] "Materials and methods: Material and method"

[0343] (Manufacture of "Nano Bubble Water A")

[0344] Using the above-mentioned apparatus and the like, "biological body introduction auxiliary agent A (nanobubble water A)" of the present invention (Example A) was produced using mineral water and air as materials.

[0345] Using "Multisizer 3" manufactured by Beckman Coulter Co., Ltd., the "nanobubble water A" prepared above was diluted 250 times for the convenience of measuring the diameter of the bubbles, and the size and number of bubbles in the diluted solution were measured. show the result in figure 1 middle.

[0346] The analysis result of "nanobubble water A" is the uppermost line graph in the figure indicated by "*".

[0347] figure 1 Analysis results: average bubble diameter: 830nm, number of bubbles: about 435,000 / ml

[0348] Therefore, the number of bubbles of "nan...

Embodiment B

[0349] [Example B: Biointroduction Auxiliary B (Containing Air Bubbles Below Nano Size)]

[0350] "Materials and methods: Material and method"

[0351] As the gas to be sealed when the bubbles are generated, air and hydrogen are used together, and the timing of filling the hydrogen is in the second half of the filling, and the hydrogen concentration in the bubbles is increased. In the same manner as in Example A, a "Biointroduction auxiliary agent B (nanobubble water B)" of the present invention (Example B).

[0352] It should be noted that the amount of hydrogen gas used in the enclosing operation was about 250 times that of the atmosphere.

[0353] The number of bubbles of "nanobubble water B" (undiluted 250 times) used in the present invention is also considered to be about 100 million / ml.

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PUM

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Abstract

To provide: a biological introduction aid for use in introducing an active substance into a living body; and a composition containing the biological introduction aid. This biological introduction aid or drug delivery system aid is for use in introducing (I)-(i) together with (I)-(ii) into a living body, and is characterized by containing (II) and (III), or this active substance-containing composition is characterized by containing (I)-(i) to (III). (I)-(i) Active substance (I)-(ii) Active substance protection agent (II) Solvent (III) Nano air bubbles (less than one micron in size).

Description

technical field [0001] The present invention relates to a "biological introduction auxiliary agent" that can be used as an auxiliary agent for a drug delivery system capable of incorporating an "active substance containing agent" containing an "active substance" and an "active substance protecting agent" such as an excipient. complexes (so-called pharmaceutical preparations, etc.)" are more reliably delivered to organisms. [0002] In addition, the present invention relates to "a composition containing an active substance" which can be more reliably introduced into a living body. [0003] Furthermore, the present invention relates to a "composition for preventing and / or treating diseases, or improving physical fitness and / or physical conditions", which can more reliably exert functions, efficacy or effects in vivo. Background technique [0004] The concept of so-called drug delivery is known as an attempt to more effectively exert the function, potency, or effect of active ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61P37/08A61K35/741A61K47/36A61P1/00A61P1/04A61P3/10A61K47/32A61K9/10A61P17/00A61K35/74A61K47/26
CPCA61K35/744A61P37/08A61K35/741A61K47/36A61P1/00A61P1/04A61P3/10A61K47/32A61K9/10A61P17/00A61K35/74A61K47/26A61K47/12A61K35/742A61K38/28A61K47/02
Inventor 清水真
Owner 真共生株式会社
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