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Traditional Chinese medicine composition for reducing blood glucose and prolonging life and preparation method thereof

A composition and hypoglycemic technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of limited efficacy, complicated and heavy metering work, and large side effects of western medicines.

Pending Publication Date: 2021-12-03
ANHUI HUAIRENTANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many western medicines for lowering blood sugar, but the side effects of western medicines are relatively large. Toxins, and toxins need to be excreted through the metabolism of the kidneys, which can easily cause aging and disease of the kidneys and other body organs, resulting in serious complications. Excessive use will cause nausea, abdominal distension, constipation, exhaust pain and many other drug-induced side effects of disease
[0005] Traditional Chinese medicine is widely praised because of its low toxicity and side effects. For example, the Chinese patent document CN103386040A discloses a hypoglycemic traditional Chinese medicine preparation, which includes raw rehmannia root, Morus alba cortex, Digu cortex, corn silk, trichosanthin, Coptis chinensis, Yinmanhuo, Acanthopanax , Polygonatum, Rhodiola Rosea, Gastrodia elata, Lycium barbarum, Chuanxiong, Anemarrhena, Inulae, and Ginseng, a total of sixteen Chinese herbal medicines. Dosage, complex formula, strict dosage, which makes the metering work complicated and heavy
In addition, most traditional Chinese medicine preparations are taken after decoction, which is inconvenient to take, or directly crushed and then taken as powder. The dissolution rate of active ingredients in the medicinal materials is low, and the efficacy is limited.

Method used

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  • Traditional Chinese medicine composition for reducing blood glucose and prolonging life and preparation method thereof
  • Traditional Chinese medicine composition for reducing blood glucose and prolonging life and preparation method thereof
  • Traditional Chinese medicine composition for reducing blood glucose and prolonging life and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0059] (2) Preparation of mulberry leaf extract powder:

[0060] Use a wall breaking machine to crush the mulberry leaves to less than 1mm, and extract the mulberry leaf powder separately. The extraction method is as follows: add water to decoct, add 10 times the amount of water to decoct for 2 hours, filter the decoction, and place the filtrate in a clean container , set aside; add 8 times the amount of ethanol to the filter residue, extract with alcohol for 2 hours, combine the extract with the filtrate of the first decoction and then concentrate until the relative density is 1.02-1.10;

[0061] Combine the mulberry leaf extract concentrate for later use, add β-cyclodextrin into water and mix evenly according to the solid-to-liquid ratio of 1:7, then add the extract concentrate, homogenize to obtain a mixed solution, spray dry after homogenization, The feed rate of spray drying is 12mL / min, the inlet air temperature is 120°C, and the moisture content of the dried product is ...

Embodiment 1

[0068] The traditional Chinese medicine composition for lowering blood sugar and prolonging life is composed of the following raw materials: 180 grams of kudzu root, 150 grams of salvia miltiorrhiza, 150 grams of Chinese yam, 130 grams of tartary buckwheat, 100 grams of medlar, 100 grams of astragalus, 100 grams of radix radix, 100 grams of pumpkin seeds 100 grams, 90 grams of mulberry leaves, 60 grams of American ginseng, 60 grams of Yuzhu, and 60 grams of Polygonum multiflorum.

[0069] The powdered traditional Chinese medicine composition prepared from the crude drug of the above weight is a 30-day dose, taken twice a day, 20 ± 2g once a day.

[0070] According to the following Table 1, several groups of powder medicines of the traditional Chinese medicine composition of the present invention were prepared, and the remaining raw material components remained unchanged, which were respectively used as experimental group 1, experimental group 2, experimental group 3, experiment...

Embodiment 2

[0073] The instant test of embodiment 2 mulberry leaf extract powder:

[0074] Take the mulberry leaf mixed extract powder prepared according to Example 1, add water at a temperature of 60 ° C, stir and mix, and observe after standing for 1 hour:

[0075] Results: After 1 hour, the powder was evenly dispersed in the water, and there was no agglomeration and suspension on the water surface. With the prolongation of the standing time, no precipitation was seen, and no stratification was seen. Therefore, the mulberry leaf mixed extract powder has a good effect. Excellent solubility and stability, excellent instant performance.

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Abstract

The invention discloses a traditional Chinese medicine composition for reducing blood glucose and prolonging life. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: radix puerariae, radix salviae miltiorrhizae, tartary buckwheat, Chinese yam, fructus lycii, radix astragali, radix ophiopogonis, pumpkin seeds, folium mori, American ginseng, radix polygonati officinalis and radix polygoni multiflori preparata. The radix puerariae, the radix salviae miltiorrhizae and the American ginseng are micropowder obtained after wall breaking and crushing, and have a particle size smaller than 10-20 [mu]m; the Chinese yams, the fructus lycii, the radix polygonati officinalis and the radix polygoni multiflori preparata are powder obtained by performing hypoglycemic treatment on the crushed materials; and the folium mori is powder obtained by mixing a mulberry leaf extract concentrated solution with a coating agent and performing spray drying. The radix puerariae and the radix salviae miltiorrhizae are used as monarch drugs, the folium mori and the tartary buckwheat are used as ministerial drugs, the pumpkin seeds contain cucurbitine, vitamin B1 and vitamins and have a good curative effect in regulating carbohydrate metabolism, the radix polygoni multiflori preparata is used as an auxiliary drug, the radix astragali and the radix ophiopogonis are added and have effects of tonifying middle-jiao and qi, strengthening the spleen and stomach and raising yang and consolidating foundation, and the radix polygonati officinalis, the American ginseng, the Chinese yam and the fructus lycii rich in amino acid are used as adjuvant drugs. The whole formula is strictly combined and has effects of reducing blood sugar, delaying senescence and resisting aging.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for lowering blood sugar and prolonging life and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease of multiple etiologies characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion or action. On October 12, 2004, the Ministry of Health, the Ministry of Science and Technology and the National Bureau of Statistics published the report "Chinese Residents' Nutrition and Health Status", which pointed out that the prevalence of diabetes among residents aged 18 and over in my country was 2.6%, and the impaired fasting blood sugar rate was 2.6%. 1.9%. It is estimated that there are more than 20 million people with diabetes in the country, and another nearly 20 million people have impair...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/14A61K47/69A61P3/10
CPCA61K36/488A61K36/537A61K36/70A61K36/8945A61K36/815A61K36/481A61K36/8968A61K36/42A61K36/605A61K36/258A61K36/8969A61K36/704A61K36/484A61K36/185A61K47/6951A61K9/14A61P3/10A61K2236/15A61K2236/331A61K2236/333A61K2300/00
Inventor 何家裕张国升朱来良赵红孙卫华宫夏婉
Owner ANHUI HUAIRENTANG PHARMA CO LTD
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