Pharmaceutical composition for removing phlegm and removing dampness and its application
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A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of limited therapeutic effect in patients with coronary heart disease, achieve the effect of reducing inflammatory cell infiltration, reducing myocardial pathological changes, and reducing the degree of edema
Active Publication Date: 2022-07-01
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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[0004] Traditional Chinese medicine believes that coronary heart disease is caused by blood stasis, phlegm and dampness blocking the heart, so there is a classic prescription "Gualou Xiebai Banxia Decoction" (see "Synopsis of the Golden Chamber" by Zhang Zhongjing for details. Gualou Xiebai Banxia Decoction should be used"), however, the treatment effect of this prescription on a considerable number of patients with coronary heart disease such as coronary heart disease with phlegm-dampness syndrome is very limited, so it needs to be improved according to local conditions and people's conditions, so that it can benefit more coronary heart disease patients
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Embodiment 1
[0049] Huotan Chushi Decoction is prepared from the following components: 30g of whole melon, 30g of Xiebai, 15g of Pinellia fragrans, 20g of Codonopsis, 15g of Curcuma curcuma, and 6g of Coptis chinensis.
[0050] Taking the above-mentioned components, according to the existing traditional Chinese medicine decoction preparation method, Huotan Chushi Decoction is prepared, and the proportion is one dose, and one dose is about 200 mL.
[0051] Exemplarily, Huotan Chushi Decoction can be prepared by the following existing methods:
[0052] One decoction: the whole recipe is soaked in water for about 30min according to the ratio of 1g crude drug and 8mL of water, boiled for about 30min, filtered with 4 layers of gauze while hot, and the first filtrate and the first filter residue were obtained after the filtrate was naturally dripped;
[0053] Second decoction: add water to the first filter residue at the ratio of 1g crude drug plus 6mL water, boil for about 30min and filter, ret...
Embodiment 2
[0056] Huotan and dampness granules are prepared from the following components: 30g of whole melon, 30g of Xiebai, 15g of Pinellia fragrans, 20g of Codonopsis, 15g of Curcuma curcuma, and 6g of Coptis chinensis.
[0057] Take the above components, add a carrier or / excipient, and prepare 1000g of phlegm and dampness granules according to the existing traditional Chinese medicine granule preparation method.
[0058] Exemplarily, the phlegm and dampness granules can be prepared by the following existing methods:
[0059] The filtrate was obtained according to the method for preparing decoction in Example 1, and after the filtrate was concentrated under reduced pressure to obtain clear paste, maltodextrin was added to the clear paste, and then spray-dried to obtain dry paste powder; then, malt was added to the dry paste powder dextrin to obtain mixed powder; then, add 90% ethanol-water solution to the mixed powder to make soft material, sieve the soft material to obtain wet granul...
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Abstract
The invention belongs to the field of traditional Chinese medicine, and in particular relates to a medicinal composition for removing phlegm and removing dampness and application thereof. The pharmaceutical composition for removing phlegm and dehumidification of the present invention is prepared from the following raw material components in parts by mass: 15-30 parts of whole melon, 9-30 parts of Xiebai, 9-15 parts of Pinellia fragrans, 9-30 parts of Codonopsis Radix, and Curcuma 6‑15 servings, Coptis 2‑6 servings. Experiments on a mouse model of coronary heart disease with dampness syndrome show that the Huatan and dampness formula of the present invention can significantly improve ST segment and T wave depression in coronary heart disease phlegm damp syndrome mice, inhibit myocardial hypertrophy in coronary heart disease phlegm damp syndrome mice, and reduce CK-MB Leakage of myocardial injury enzyme spectrum of cTnT, LDH, oxLDL, protect myocardial tissue from ischemic injury, reduce cardiac enlargement caused by isoproterenol, reduce myocardial pathological changes caused by isoproterenol treatment, and maintain more myocardial cells The structure is normal, the infiltration of inflammatory cells is reduced, the membrane structure is stabilized, and the degree of edema is reduced, suggesting that the Hutanquushi Formula of the present invention has a better therapeutic effect on ischemic heart disease or angina pectoris.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a medicinal composition for removing phlegm and removing dampness and its application. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary vessels that cause vascular stenosis or blockage, resulting in myocardial ischemia, hypoxia or necrosis. It is often referred to as "coronary heart disease". The World Health Organization classifies coronary heart disease into five categories: silent myocardial ischemia (occult coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart disease) and sudden death. [0003] For the treatment of coronary heart disease, the success rate of treatment has increased due to the continuous development and improvement of percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG). ...
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