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Surgical sealant kit and application thereof in brain and spine surgery

A kit and sealant technology, applied in the field of medical devices, can solve the problems of high price, volume swelling, and compression of spinal nerves, and achieve the effects of fast gelation, fast cross-linking reaction, and good safety

Active Publication Date: 2021-10-22
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Take DuraSeal TM Glue and Polyethylene glycol sealant represented by glue is widely used in neurosurgery, but it is expensive
At the same time, there are also reports of related complications of this type of product, such as: after polyethylene glycol hydrogel is used to seal the wound in neurosurgery, the hydrogel absorbs body fluids, swells in volume, compresses the spinal nerves, and eventually leads to quadriplegia. event

Method used

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  • Surgical sealant kit and application thereof in brain and spine surgery
  • Surgical sealant kit and application thereof in brain and spine surgery
  • Surgical sealant kit and application thereof in brain and spine surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] In the present embodiment, a surgical sealant is provided, and the surgical sealant kit includes the following components:

[0064] (a) The first syringe: 2.4 mL of trilysine (15 g / L) phosphate buffer (1.5 mM), pH=4.0;

[0065] (b) Second syringe: borate buffer (65mM) 2.5mL, pH=9.9;

[0066] (c) Powder bottle: 0.5g polyethylene glycol derivative;

[0067] (d) Supporting tools, including push plate, syringe bracket, two-way connector, atomizing nozzle, etc.;

[0068] And use Co60 to carry out irradiation sterilization, irradiation dose is 20k; The using method of described sealant comprises the following steps:

[0069] (a) the first syringe and (c) the powder bottle are connected, the liquid is injected into the powder bottle to dissolve the polyethylene glycol derivative, and after the dissolution is completed, the liquid is drawn back into the first syringe, and then the (a) first syringe and ( b) The second syringe is installed on the bracket, the push plate is in...

Embodiment 2

[0084] In the present embodiment, another surgical sealant kit is provided, and the difference from Example 1 is that the kit is composed as follows:

[0085] (a) The first syringe: 2.4 mL of acetate buffer solution (2.5 mM) of pentalysine (15 g / L), pH=4.8;

[0086] (b) Second syringe: 2.5 mL of carbonate buffer (70 mM), pH=9.5;

[0087] (c) Powder bottle: 0.6g polyethylene glycol derivative (6-arm-PEG-SG-10k:8-arm-PEG-SG-20k=0.5:0.5), 0.0005g methylene blue;

[0088] (d) Supporting tools, including push plate, syringe bracket, two-way connector, atomizing nozzle, etc.;

[0089] And use electron beam to carry out radiation sterilization, radiation dose is 25k; Its use mode is the same as embodiment 1.

Embodiment 3

[0091] In the present embodiment, another surgical sealant kit is provided, and the difference from Example 1 is that the kit is composed as follows:

[0092] (a) The first syringe: 2.4 mL of phthalic acid buffer (2 mM) of decalysine (10 g / L), pH=3.5;

[0093] (b) Second syringe: glycine buffer (75mM) 2.5mL, pH=10.5;

[0094] (c) Powder bottle: 0.4g polyethylene glycol derivative (4-arm-PEG-SSeb-5k:8-arm-PEG-SG-15k=0.4:0.6);

[0095] (d) Supporting tools, including push plate, syringe bracket, two-way connector, atomizing nozzle, etc.;

[0096] And use electron beam to carry out radiation sterilization, radiation dose is 5k; Its use mode is the same as embodiment 1.

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Abstract

The invention relates to a surgical sealant kit and application thereof in brain and spine surgery. The surgical sealant kit comprises a first injector containing an acidic buffer solution of an amino compound; a second syringe containing an alkaline buffer solution; a powder bottle containing two polyethylene glycol derivatives of different structures and / or molecular weights; and matched tool that comprises a push plate, an injector bracket, a two-way connector, an atomizing nozzle and other parts. The sealant is hydrogel formed by compounding and cross-linking two polyethylene glycol derivatives with different molecular weights and / or structures and an amino compound, meanwhile, the amino compound is dissolved in the acidic buffer solution, so that the swelling ratio of the sealant is further reduced, and the gel forming speed is increased. The kit has the characteristics that the swelling rate is greater than-20% and less than 20%, and the gel forming time is less than 1s, and can be used for auxiliary sealing of surgical parts such as brain and spine.

Description

technical field [0001] The invention belongs to the technical field of medical instruments, and in particular relates to a surgical sealant kit and the application of the surgical sealant kit in brain and spine-related surgeries. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Medical sealant belongs to the category of biomedical engineering materials. It is generally in a liquid state before use, and becomes a gel during use, and finally plays the role of bonding wounds, stopping bleeding, preventing leakage, preventing seepage, and preventing adhesion. Currently clinically applied medical sealant products include: natural component sealant (fibrin glue), semi-synthetic ...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00
CPCA61L24/0094A61L24/0042A61L2400/04C08L71/02
Inventor 邹方明李刚苑康见赵艳董芳芳邓凤娟
Owner SAIKE SAISI BIOTECH CO LTD
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