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Antiviral solution preparation for aerosol inhalation and preparation method thereof

A technology of atomization inhalation, antiviral oral liquid, applied in the field of preparation, can solve the problems of slow onset, large toxic side effects, large dosage and the like

Inactive Publication Date: 2021-09-10
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of oral administration is slow, the dosage is large, and the side effects are relatively large. Therefore, it is urgent to develop a safer dosage form, so that the drug can directly enter the respiratory tract.

Method used

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  • Antiviral solution preparation for aerosol inhalation and preparation method thereof
  • Antiviral solution preparation for aerosol inhalation and preparation method thereof
  • Antiviral solution preparation for aerosol inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Preparation of active ingredients:

[0038] 12.87 parts of isatidis, 4.65 parts of forsythia, 5.72 parts of gypsum, 2.5 parts of anemarrhena, 3.22 parts of rehmannia glutinosa, 2.50 parts of calamus, 2.50 parts of turmeric, 2.86 parts of patchouli, 6.08 parts of reed root

[0039] Weigh Jiuwei medicine according to the above weight, add water and decoct twice, collect volatile oil for 3 hours for the first time, and clathrate with hydroxypropyl beta cyclodextrin, or collect volatile oil and volatile oil emulsion at the same time for 1.5 hours for the first time Turbid liquid; for the second time, filter for 1 hour and 20 minutes, combine the filtrates, concentrate to an appropriate amount, add more than 85% ethanol to make the alcohol content 70%, let stand, filter, recover ethanol from the filtrate and concentrate to an appropriate amount, add The inclusion compound of volatile oil or adding volatile oil and volatile oil emulsion to obtain the active ingredient of ...

Embodiment 2

[0045] (1) Preparation of active ingredient: same as Example 1.

[0046] (2) Preparation of antiviral atomized inhalation solution:

[0047]

[0048] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take sodium chloride, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, and stir evenly to obtain solution 2. Solution 3: Take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.4mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 4.0-7.0, add 1000ml of water for injection, fill and seal, Instantly.

Embodiment 3

[0050] (1) Preparation of active ingredient: same as Example 1.

[0051] (2) Preparation of antiviral atomized inhalation solution:

[0052]

[0053]

[0054]Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take magnesium chloride and citric acid, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, stir evenly, Obtain solution 3; take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.2mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 4.0-6.0, add 1000ml of water for injection, fill and seal , that is.

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Abstract

The invention relates to an antiviral solution preparation for aerosol inhalation, and belongs to the field of pharmaceutics. The antiviral solution preparation for aerosol inhalation comprises (1) an antiviral effective component; and (2) an isotonic agent and a solvent, and the preparation also can comprise a buffer solution. The solution preparation makes up the blank in the current domestic market, and can avoid the lack of inhalation of special preparation medicines for treatment. The solution preparation is specially designed for patients for aerosol inhalation, is matched with an atomizer for use, is convenient in use process, and is different in administration route, reduced in use dosage and improved in safety compared with antiviral oral liquid.

Description

[0001] The present invention is a divisional application of the Chinese invention patent application with the application number 201610023855.5, the application date is January 15, 2016, and the invention title is "An Antiviral Atomized Inhalation Solution Preparation and Its Preparation Method". Cited, incorporated in full text. technical field [0002] The invention relates to an antiviral solution preparation for atomized inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0003] Influenza (abbreviated as influenza) is an acute respiratory infection caused by influenza virus, and it is also a disease with strong contagion and fast transmission speed. It is mainly spread through droplets in the air, person-to-person contact or contact with contaminated items. Typical clinical symptoms are: sudden onset of high fever, general pain, significant fatigue and mild respiratory symptoms. Generally, autumn and winter are the hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/72A61K9/08A61K47/69A61K47/26A61K47/02A61K47/12A61P11/00A61P31/12A61P31/16
CPCA61K36/8964A61K36/899A61K36/9066A61K33/06A61K36/195A61K36/315A61K36/634A61K36/804A61K36/888A61K2236/39A61K2236/331A61K36/532A61K9/0078A61K9/08A61K47/6951A61K47/26A61K47/02A61K47/12A61P11/00A61P31/16A61P31/12A61K2300/00
Inventor 张保献
Owner INCREASEPHARM HENGQIN INST CO LTD
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