A traditional Chinese medicine compound preparation for the treatment of viral pneumonia

A technology for viral pneumonia and compound preparations, which can be used in compound preparations for the treatment of virus-induced acute lung injury and respiratory tract inflammation, and in the field of traditional Chinese medicine compounds, which can solve problems such as destruction of gas exchange barriers, damage, and excessive activation of host immune mechanisms.

Active Publication Date: 2022-07-29
王停
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the pathways or targets of various viruses infecting cells may be different, these viruses usually invade the bronchiole epithelium to cause bronchiolitis, and infect lung cells, lung interstitium and alveoli to cause pneumonia; the virus can infect respiratory epithelial cells and vascular endothelial cells, damage lung tissue, and destroy the gas exchange barrier; and release a large number of cytokines through macrophages, segmental neutrophils, lymphocytes, and endothelial cells, and the host immune mechanism is overactivated and out of control , resulting in acute lung injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of formulation

[0017] Weigh 9 parts of ephedra, 20 parts of raw gypsum (fried first), 3 parts of cooked rhubarb, 9 parts of Shegan, 10 parts of aster, 9 parts of coltsfoot, 15 parts of dried tangerine peel, 9 parts of ginger pinellia, 20 parts of Poria, 9 parts of almond, 10 parts of cicada 10 copies of Zhebei, 15 copies of Gongying, and 15 copies of Campanulaceae.

[0018] Preparation steps: the weighed Chinese medicinal materials (which can also be directly converted into formula granules) are decoctioned into decoction according to traditional technology or processed into tablets and pills defined in Chinese Pharmacopoeia according to conventional Chinese patent medicine preparation technology. , capsules, granules, powders or oral liquids are the main clinical Chinese patent medicine preparations for the treatment of viral pneumonia.

Embodiment 2

[0020] Animal experiment: Study on the effect of using syncytial virus RSV combined with ovalbumin to induce sensitized mice to establish an animal model of acute viral pneumonia

[0021] 72 BALB / C6-8 weeks female mice (16-18g) were randomly divided into 6 groups (A, B, C, D, E, F) according to body weight: group A was the normal control group, group B was the RSV virus Model group, group C is the high-dose compound preparation group (40 mg / kg), group D is the middle-dose group (mg / kg), group E is the low-dose group, and group F is the positive control ribavirin group 100 mg / kg , 12 animals in each group; animals in all groups except group A were induced to sensitize mice by RSV combined with OVA to establish an animal model of acute viral pneumonia. Seven days of continuous administration, 14 days after drug withdrawal, the body weight, number of survivors, number of deaths and changes in symptoms were recorded every day, and the life protection rate and body weight changes o...

Embodiment 3

[0024] Animal experiment: study of antitussive effect

[0025] ICR mice were reared adaptively for 1 week, fasted for 12 hours before the experiment, placed in a 5000 ml self-made glass device, turned on the atomizer, sprayed 25% ammonia water at constant pressure for 30 s, and observed the cough reflex of the mice ( The abdominal muscles are strongly contracted, and the mouth is opened and exhaled at the same time), and the number of coughs more than or equal to 3 times within 1 minute is judged to be qualified for the initial screening of cough induction. 80 qualified mice were taken and randomly divided into 5 groups according to body weight, namely model group, positive drug Kebiqing group, high-dose group, middle-dose group and low-dose group of the preparation of the present invention, with 12 mice in each group, half male and half male. The test drugs were suspended with 0.5% CMC-Na and administered by gavage, 0.1 ml / 10g BW, once a day, for 7 consecutive days, and the mic...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for the treatment of viral pneumonia. It is characterized in that it is made from fourteen Chinese medicinal materials of ephedra, raw gypsum, cooked rhubarb, shegan, aster, coltsfoot, tangerine peel, ginger pinellia, tuckahoe, almond, cicada slough, Zhejiang fritillary, gongying, and platycodon grandiflorum. For patients with early stage viral pneumonia caused by viral infections such as influenza virus, parainfluenza virus, cytomegalovirus, syncytial virus, adenovirus, rhinovirus or coronavirus (including novel coronavirus 2019‑nCoV), it can rapidly improve fatigue, It can effectively improve the chest imaging manifestations of viral pneumonia. The traditional Chinese medicine compound preparation has remarkable curative effect and unique refined formula, and has been specially optimized to meet the needs of new traditional Chinese medicine development.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, relates to a traditional Chinese medicine compound, and in particular relates to a traditional Chinese medicine compound preparation for the treatment of viral pneumonia. Fatigue, cough and sore throat can effectively improve the chest imaging manifestations of viral pneumonia. Background technique [0002] There are more than 100 pathogens causing community-acquired pneumonia, of which viruses account for about 30%. The so-called viral pneumonia (viral pneumonia) is the inflammation of the lungs caused by viral infection, usually caused by the downward spread of the virus from the upper respiratory tract infection. Viruses that can cause viral pneumonia include influenza virus, parainfluenza virus, cytomegalovirus, syncytial virus, adenovirus, rhinovirus, coronavirus and some enteroviruses. Among them, the coronavirus subfamily is divided into four genera: alpha, beta, gamma, and de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8966A61P31/12A61P31/14A61P31/16A61P11/00A61P11/14A61P11/04A61K35/64A61K33/06
CPCA61K36/17A61K33/06A61K36/708A61K36/88A61K36/28A61K36/752A61K36/8888A61K36/076A61K36/736A61K35/64A61K36/8966A61K36/288A61K36/346A61P31/12A61P31/14A61P31/16A61P11/00A61P11/14A61P11/04A61K2300/00
Inventor 不公告发明人
Owner 王停
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