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Superstrong anti-oxidative deformation vesicle, and preparation method and application thereof

An anti-oxidation and vesicle technology, applied in the direction of cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of easy oxidative decomposition, not very stable, easy to decompose, etc., to improve stability, solubility, elasticity/deformability Good, safe and mild raw materials

Inactive Publication Date: 2021-08-13
苏州纳康生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, ethylbisiminomethylguaiacol manganese chloride has some problems in the actual application process, including not very stable in aqueous solution, easy to decompose, affecting the use effect, in addition, it cannot be used with acidic substances at the same time, and it is easy to oxidize decomposition, which limits its wide application

Method used

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  • Superstrong anti-oxidative deformation vesicle, and preparation method and application thereof
  • Superstrong anti-oxidative deformation vesicle, and preparation method and application thereof
  • Superstrong anti-oxidative deformation vesicle, and preparation method and application thereof

Examples

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preparation example Construction

[0030] A method for preparing super-antioxidative deformed vesicles, comprising the following steps:

[0031] 1) Weigh ethylbisiminomethylguaiacol manganese chloride, sucrose laurate, glycerin, PPG- 13-decyltetradeceth-24 and butanediol; as a preference, the ethylbisiminomethylguaiacol manganese chloride, the sucrose laurate, the glycerin, the PPG The mass ratio of -13-decyltetradeceth-24 to the butanediol is 2:1-8:9-13:12-15:56-70.

[0032] 2) Ethylbisiminomethylguaiacol manganese chloride, PPG-13-decyltetradeceth-24 and butanediol weighed in step 1) were heated to 55-75° C. Mix and stir at 500-1000RPM for 20-40mins until completely dissolved to obtain solution A; preferably, the heating temperature is 60-65°C;

[0033] 3) Stir the sucrose laurate and glycerin weighed in step 1) at room temperature for 35-55mins until transparent to obtain solution B;

[0034] 4) Add solution A obtained in step 2) to solution B obtained in step 3), mix well, and then heat to 55-75°C to obt...

Embodiment 1

[0042] Embodiment 1: The preparation of a kind of super anti-oxidation deformed vesicle adopts the following steps:

[0043] A: Weigh ethylbisiminomethylguaiacol manganese chloride, sucrose laurate, glycerin, PPG-13-decyl tetradeceth- 24 and butanediol;

[0044] B: Heat the ethylbisiminomethylguaiacol manganese chloride, PPG-13-decyltetradeceth-24 and butanediol weighed in step A to 60°C at 500RPM Mix and stir until completely dissolved;

[0045] C: Stir the sucrose laurate and glycerin weighed in step A until transparent at room temperature, and set aside;

[0046] D: Add the ethylbisiminomethylguaiacol manganese chloride solution obtained in step B to the mixture obtained in step C, mix well, and then heat to 63°C to obtain a premixed solution;

[0047] E: The premixed solution obtained in step D is circulated and homogenized by a high-pressure homogenizer at 63°C and a pressure of 80Mpa for 6 times, and the homogenized liquid is filtered through a stainless steel filter ...

Embodiment 2

[0048] Embodiment 2: The preparation of a kind of super anti-oxidation deformed vesicle adopts the following steps:

[0049] A: Weigh ethylbisiminomethylguaiacol manganese chloride, sucrose laurate, glycerin, PPG-13-decyltetradeceth- 24 and butanediol;

[0050] B: Heat the ethylbisiminomethylguaiacol manganese chloride, PPG-13-decyltetradeceth-24 and butanediol weighed in step A to 65°C under the condition of 1000RPM Mix and stir until completely dissolved;

[0051] C: Stir the sucrose laurate and glycerin weighed in step A until transparent at room temperature, and set aside;

[0052] D: Add the ethylbisiminomethylguaiacol manganese chloride solution obtained in step B to the mixture obtained in step C, mix well, and then heat to 62°C to obtain a premixed solution;

[0053] E: The premixed solution obtained in step D is circulated and homogenized through a high-pressure homogenizer at 62°C and a pressure of 120Mpa for 3 times, and the homogenized liquid is filtered through...

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Abstract

The invention discloses preparation of a superstrong anti-oxidative deformation vesicle. The superstrong anti-oxidative deformation vesicle is prepared from ethyl diimino methyl guaiacol manganese chloride, sucrose laurate, glycerol, PPG-13-decyl tetradecanol polyether-24 and butanediol according to the mass ratio of (3-4):(2-10):(8-15):(10-18):(50-80). The superstrong anti-oxidative deformation vesicle prepared by the invention has the beneficial effects of high content of active ingredients, good transdermal absorbability, good stability, low irritation and remarkable anti-oxidative effect; the preparation method is simple and controllable; the repeatability is good; and the superstrong anti-oxidative deformation vesicle can be directly applied to cosmetics with anti-oxidative effects in various dosage forms.

Description

technical field [0001] The invention relates to the technical field of cosmetics, more specifically, it relates to a super-strong anti-oxidation deformation vesicle, its preparation method and application. Background technique [0002] Over time, oxidation is the biggest threat to skin aging. Factors such as sun exposure, stress, and environmental pollution promote accelerated oxidation of skin cells, resulting in lipid peroxidation, amino acid and protein denaturation, glycosylation, and endogenous DNA Injuries and other oxidative stress states, followed by skin damage, and signs of aging appear, so the demand for antioxidant products is strong, and the market potential is huge. [0003] Ethylbisiminomethylguaiacol manganese chloride is a synthetic superoxide dismutase (SOD) / catalase analog that disproportionates superoxide free radicals and eliminates hydrogen peroxide with potent It has effective antioxidant activity and plays a catalytic role in this process. It does no...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/02A61K8/34A61K8/49A61K8/60A61Q19/06
CPCA61K8/86A61K8/345A61K8/60A61K8/49A61K8/0291A61Q19/06A61K2800/522
Inventor 夏强安冬欧雪莲黄一鸣邓笑颖
Owner 苏州纳康生物科技有限公司
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