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A high-safety non-inactivated virus preservation solution and its preparation method

A high-safety, preservation solution technology, applied in the medical field, can solve problems such as virus infection, achieve the effects of reducing infectivity, improving safety, and strengthening inhibition

Active Publication Date: 2021-12-14
MIRACLEAN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the virus preserved in this protective solution has strong activity, and if there is improper handling during operation, it will cause virus infection

Method used

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  • A high-safety non-inactivated virus preservation solution and its preparation method
  • A high-safety non-inactivated virus preservation solution and its preparation method
  • A high-safety non-inactivated virus preservation solution and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A high-safety non-inactivated virus preservation solution is characterized in that it includes hanks base solution, antibiotic medicament, protein protectant, cryoprotectant and nutritional agent, and the protein protectant includes bovine serum albumin and mannitol , glycerin, butylene glycol, sodium chloride and sodium benzoate, the cryoprotectant includes sodium alginate, polyethylene glycol, glucose, and the nutrient includes asparagine, glutamine, threonine, aspartame amino acid, valine, leucine, isoleucine, said antibiotic agents include gentamicin, amclocillin sodium and amikacin;

[0031] The weight ratio of each substance in the non-inactivated virus preservation solution is: 100 parts of Hanks base solution, 4 parts of antibiotic medicament, 3 parts of protein protection agent, 1 part of cryoprotectant and 1 part of nutrient;

[0032] The weight ratio of each substance in the protein protectant is: 10 parts of bovine serum albumin, 8 parts of mannitol, 2 parts...

Embodiment 2

[0037] A high-safety non-inactivated virus preservation solution is characterized in that it includes hanks base solution, antibiotic medicament, protein protectant, cryoprotectant and nutritional agent, and the protein protectant includes bovine serum albumin, mannitol , glycerin, butylene glycol, sodium chloride and sodium benzoate, the cryoprotectant includes sodium alginate, polyethylene glycol, glucose, and the nutrient includes asparagine, glutamine, threonine, aspartame amino acid, valine, leucine, isoleucine, said antibiotic agents include gentamicin, amclocillin sodium and amikacin;

[0038] The weight ratio of each substance in the non-inactivated virus preservation solution is: 100 parts of Hanks base solution, 4 parts of antibiotic medicament, 3 parts of protein protection agent, 1 part of cryoprotectant and 1 part of nutrient;

[0039] The weight ratio of each substance in the protein protectant is: 10 parts of bovine serum albumin, 8 parts of mannitol, 2 parts of...

Embodiment 3

[0051] A high-safety non-inactivated virus preservation solution is characterized in that it includes hanks base solution, antibiotic medicament, protein protectant, cryoprotectant and nutritional agent, and the protein protectant includes bovine serum albumin, mannitol , glycerin, butylene glycol, sodium chloride and sodium benzoate, the cryoprotectant includes sodium alginate, polyethylene glycol, glucose, and the nutrient includes asparagine, glutamine, threonine, aspartame amino acid, valine, leucine, isoleucine, said antibiotic agents include gentamicin, amclocillin sodium and amikacin;

[0052] The weight ratio of each substance in the non-inactivated virus preservation solution is: 100 parts of Hanks base solution, 4 parts of antibiotic medicament, 3 parts of protein protection agent, 1 part of cryoprotectant and 1 part of nutrient;

[0053] The weight ratio of each substance in the protein protectant is: 10 parts of bovine serum albumin, 8 parts of mannitol, 2 parts of...

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Abstract

The invention provides a high-safety non-inactivated virus preservation solution and a preparation method thereof. The preservation solution includes hanks base solution, antibiotic medicament, protein protectant, cryoprotectant and nutrient, and the protein protectant includes bovine Serum albumin, mannitol, glycerin, butylene glycol, sodium chloride and sodium benzoate, described cryoprotectant comprises sodium alginate, polyethylene glycol, glucose, and described nutrient comprises asparagine, glutamine, threonine, aspartic acid, valine, leucine, isoleucine, said antibiotic agent includes gentamicin, amclocillin sodium and amikacin. Inhibit the influence of bacteria and fungi on viruses by antibiotics, protect the protein shell of viruses by protein protectants, stabilize the protection solution at low temperatures by cryoprotectants, and enable viruses to survive in the protection solution by nutrients .

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a high-safety non-inactivated virus preservation solution and a preparation method. Background technique [0002] The virus preservation solution is used for the collection, preservation and transportation of common virus samples such as new coronavirus, influenza virus, hand-foot-mouth virus, etc. When the sampling tube is submerged in the sample swab virus sample, it is a liquid that protects the virus to be tested. It can collect throat swabs, Nasal swabs or tissue samples from specific parts, stored samples can be used for subsequent clinical experiments such as nucleic acid extraction or purification. [0003] Many non-inactivated virus preservation solutions have been developed. After a large number of searches and references, we found that the existing preservation solutions are as disclosed in the publication numbers KR1020100015613A, KR1020170095270A and KR1020100049506...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/24
CPCC12Q1/24
Inventor 董占龙龙波翟赢梁欣裕覃玲
Owner MIRACLEAN TECH
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